Term
What is the treatment for mild hemorrhage associated w/ Warfarin? |
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Definition
Vitamin K 1-5 mg IV (1mg/min) or 10-20 mg PO
bleeding is reversed in 4-24 hrs |
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Term
What is the treatment for severe bleeding associated w/ Warfarin? |
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Definition
FFP, recombinant factor VIIa, prothrombin complex |
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Term
What do antifibrinolytics do?
Name two. |
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Definition
They reversibly bind w/ plasminogen preventing its conversion to plasmin and the breakdown of fibrin (reduces bleeding)
Trasylol & Amicar |
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Term
Aprotonin (Trasylol) does what? When is it frequently used? |
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Definition
Its a broad spectrum protease inhibitor, that inhibits the formation of plasmin that leads to clot formation and an increase in vWBF binding.
Its frequently used in re-do hearts |
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Term
What is the test dose for Tralysol? Whats a problem w/ it? |
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Definition
Test dose is 1 ml (10,000 KIU) over 10 mins prior to loading dose.
A problem associated w/ it is, risk for anaphylactic or anaphylactoid reactions |
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Term
Whats the "full hammersmith" dose of Aprotinin (Tralysol)? |
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Definition
2,000,000 KIU IV over 20-30 min and 2,000,000 KIU in priming solution of pump
IV drip of 500,000 KIU for length of case until chest is closed |
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Term
Whats the elmination half life of Tralysol & how's it eliminated? |
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Definition
1.5-2 hrs
eliminated in the kidneys |
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Term
Whats the dose of Amicar? How's it given? |
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Definition
IV dose 4-5 grams over 1 hour followed by a drip of 1 gm per hour
HEART ROOM: 100 mg/kg over 10 min
it can be PO or IV |
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Term
When can Amicar be used? When can it NOT? |
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Definition
Besides hearts, for bleeding hemophiliacs who have undergone tooth extractions, nose bleeds, severe hematuria, abruptio placenta, and trauma.
NOT in active intravascular clotting processes such as DIC |
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