Term
| Brand name for Valproate or Vaplroic acid? |
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Definition
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Term
| Brand name for Divalproex? |
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Definition
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Term
| Black box warning for Depakene? |
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Definition
(1) Hepatic Failure
(2) Teratogenicity
(3) Pancreatitis |
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Term
| Pregnancy category of Divalproex? |
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Definition
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Term
| What must be monitored when on Divalproex? |
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Definition
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Term
| Brand name for Carbamazepine? |
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Definition
| Tegretol; Tegretol XR; Carbatrol; Epitol |
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Term
| What effect does carbamazepine have on metabolism? |
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Definition
Potent inducer and autoinducer --> decrease level of many other drugs, and decrase carbamazepine level (itself). |
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Term
| Pregnancy category of Carbamazepine? |
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Definition
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Term
| What should be monitored while taking Carbamazepine? |
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Definition
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Term
| Brand name for Lamotrigine? |
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Definition
Lamictal; Lamictal ODT; Lamictal CD (chewable); Lamicatal XL |
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Term
| Black box warnings for Lamotrigine? |
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Definition
serious skin reactions, including SJS and TEN; increased risk with high starting doses, rapid increases, or co-administration of valproic acid, which increases lamotrigine levels > 2 fold.
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Term
| How to decrease the risk of rash associated with lamotrigine? |
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Definition
follow titration schedule - Lamictal starter Kit and Lamictal ODT patient Titration kits provided the recommended titration schedule for the 1st five weeks. |
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Term
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Definition
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Term
| Can lithium be used in renal impairment? |
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Definition
Cannot use with renal impairment: lithium is 100% renally cleared - and it not eliminated, toxicity will result. |
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Term
| Should lithium be taken with meals? |
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Definition
| Yes, take with meals or change to ER forms. |
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Term
| Therapeutic range for lithium? |
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Definition
0.6 - 1.2 mEq/L (some acutely manic cases may need up to 1.5 initally). |
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Term
| At what levels does lithium toxicity occur? |
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Definition
> 1.5 mEq/L (coarse hand tremor, vomiting, presistent diarrhea, confusion, ataxia)
>3 mEq/L (CNS depression, arrhythmia, seizures, irreversible brain damage, coma) |
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Term
| Additional agents approved for Bipolar Mania? |
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Definition
aripiprazole, chlorpromazine, olanzapine, risperidone, quetiapine, ziprasidone |
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Term
| Additonal agents approved for Bipolar Depression |
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Definition
| Combination drug olanzapine - fluoxetine (Symbyax); the antipsychotic quetiapine |
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Term
| Valproic acid/divalproex acid can increase levels of? |
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Definition
amitriptyline, carbamazepine, lamotrigine, lorazepam, nortriptyline, paroxeting, phenobarbital, warfarin and zidovudine.
* A lot of things. |
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Term
| Valproate and what should be avoided because of the increased risk of rash? |
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Definition
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Term
Salicylates may displace _______ from protein - binding site, leading to toxicity and _____ can displace pheytoin from albumin, resutling in phenytoin toxicity. |
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Definition
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Term
| Carbapenems can decrease ____ levels leading to ______. |
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Definition
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Term
| Should valproic acid be used in those with liver disease? |
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Definition
Do not use in those with liver disease.
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Term
| What is a rare disease that Valproate has caused? |
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Definition
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Term
| Can a regular home teaspoon be used to measure outt he dose of valproate acid? |
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Definition
| No. Ask pharamacist for graduated measurer. |
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Term
| What pregnancy category is valproic acid? |
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Definition
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Term
| How would carbamazepine would affect oral contraceptives? |
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Definition
Carbamazepine is a strong CYP 450 3A4 inducer and auto inducer. It will decrease th levels of many drugs, including oral contraceptives, valproic acid, levothyroxine, warfaring and many others. |
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Term
Carbamazepine can rarely cause very serious (possibly fatal) skin reactions. If you are of ___ descent, your much have a blood test prior to using this medicing to determine if you are at greater risk. |
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Definition
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Term
Carbamazepine has (rarely) caused a severe decline in ______ function, and caused the condition ______ or ________. A patient would have to his/her ______ checked to make sure ths is not occuring. |
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Definition
bone marrow; aplastic anemia; agranulocytosis; blood |
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Term
| Carbamazepine is FDA pregnancy catergory? |
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Definition
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Term
Just know that salt intake and dehydration can adversly affect lithium (increase or decrease) |
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Definition
Statement. Not a question.
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Term
| Do not crush, chew, or break any extended - release forms of lihium. What are some examples of extended release lithium? |
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Definition
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Term
| What pregnancy category is lithium? |
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Definition
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Term
Those taking lithium must drink adequate fluid because levels of dehydration can cause toxicity (so watch out while exercising!). |
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Definition
| Statement. Not a question. |
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Term
Aside from water, what other dietary component should be maitained?! |
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Definition
Do not change the amount of salt you consume. |
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