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Pregnancy and Lactation
Overview
41
Accounting
Pre-School
03/29/2013

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Cards

Term
Is safe and efficacious in the treatment of nausea and vomiting in pregnancy
Definition
Doxylamine, Droperidol, Metoclopramide, Pyridoxine
Term
Nausea and vomiting in pregnancy
Definition
Prevalence is up to 80%
Term
General physiologic and pharmacokinetic changes seen in pregnancy
Definition
decreased proportion of bound drug with highly protein bound medications
Term
Risks of using NSAIDs (including aspirin) during pregnancy
Definition
prolonged gestation/labor; oligohydramnios; hemorrhage; narrowing of the fetal ductus arteriosus
Term
The iPLEDGE program is associated with this drug
Definition
Isotretinoin
Term
Metabolic activity of CYP1A2 and 2C19
Definition
often decreased during pregnancy
Term
Have an increased volume of distribution and decreased half life in pregnant women compared to non-pregnant
Definition
aminioglycosides
Term
after the embryonic period (between weeks 2 and 8 postfertilization) the conceptus is renamed this
Definition
fetus
Term
pregnancy lasts approximately:
Definition
40 weeks or 9 months
Term
refers to the age of the embryo or fetus beginning with the first day of the last menstrual period which is about 2 weeks prior to fertilization
Definition
Gestational age
Term
the number of times a woman is pregnant
Definition
Gravidity
Term
number of pregnancies exceeding 20 weeks gestation; relates information regarding the outcome of each pregnancy
Definition
Parity
Term
increases progressively; peak values on average 30% to 50% more than preconception levels by 25- to 30-weeks gestation
Definition
Cardiac outputs
Term
hypercoagulability: risk of venous thromboembolism
Definition
4 times greater in pregnancy
Term
expansion of both plasma and red blood cell volumes
Definition
leads to an expansion of total blood volume by approx. 1.5 to 1.6 L (40% increased in volume compared to non-pregnant women)
Term
overall decreased lung capacity by 5%
Definition
maternal oxygen consumption increases over gestation reflecting the increasing demands of the growing fetus and placenta
Term
renal blood flow increased across gestation
Definition
about 50%
Term
renin-angiotensin aldosterone system
Definition
increased activity during pregnancy
Term
GI motility and gastroesophageal sphincter tone
Definition
decreased in pregnancy
Term
ADME
Definition
Absorption, distribution, metabolism, excretion
Term
do not survive due to the complexity of fertilization and subsequent pregnancy effects
Definition
About 50% of embryos
Term
survive the first 2 weeks of gestation are lost spontaneously later
Definition
about 15% of pregnancies
Term
baseline prevalence of major congenital malformations
Definition
3-5% at birth
Term
congenital anomalies
Definition
account for 20% of infant deaths
Term
birth defect risk is greatest
Definition
between weeks 3 and 8
Term
the ability of an agent to cause a defect or malformation in a fetus
Definition
teratogenicity
Term
Francis Kelsey refused to approve this in US despite culture and laws telling her to approve it
Definition
Thalidomide
Term
Isotretinoin
Definition
Accutane (avoid in pregnancy)
Term
most modifiable cause of birth defects, no safe level of exposure, increased incidence of SIDS, Colic, Respiratory problems, Hospital admissions
Definition
Tobacco
Term
causes catecholamine release and vasoconstriction
Definition
nicotine
Term
increases risk of CVD, toxins in tobacco smoke are responsible for majority of adverse health effects
Definition
Cigarettes
Term
recommend iron in pregnancy
Definition
27 mg daily
Term
Folic acid dosing in pregnancy
Definition
600 mcg/day
Term
characterized by severe persistent vomiting; 3rd leading cause of hospitalization in pregnancy
Definition
hyperemesis gravidarum
Term
one of the most effective treatment options for N/V in the past
Definition
Bendectin (tri-ingredient product)
Term
1st line for heartburn in pregnancy
Definition
calcium carbonate, magnesium hydroxide, aluminum hydroxide, sodium bicarbonate (best to avoid)
Term
2nd line for heartburn
Definition
Ranitidine, cimetidine (both cross placenta but are considered safe)
Term
treatment for constipation in pregnancy
Definition
bulk forming agents (bran, psyllium, methylcellulose)
Term
The higher the maternal plasma level
Definition
the higher the transfer to milk
Term
more medication can enter milk in colostral phase; limited volume of colostrum
Definition
composition: colostrum
Term
less medication enter; larger volume
Definition
composition: mature milk
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