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Practice Exam 1
Ototoxicity
36
Audiology
Graduate
09/19/2017

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Term
The adult cochlea is formed by the ___ fetal month
Definition
5th
Term
What is the scala media filled with?
Definition
endolymph AND corilymph
Term
What are 4 common side effects of ototoxicity?
Definition
Tinnitus, aural fullness, change in hearing sensitivity, and vertigo
Term
What is the term for what the body does with a drug?
Definition
Pharmokinetics
Term
What is the term for what a drug does to the body?
Definition
Pharmodynamics
Term
What clinical trial is when the drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely?
Definition
Phase 3
Term
What is the clinical trail where researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Definition
Phase 1
Term
What is the clinical trial where studies are done after the drug or treatment has been marketed to gather information on the drug’s effect in various populations and any side effects associated with long-term use.
Definition
Phase 4
Term
What is the clinical trial where the drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Definition
Phase 2
Term
"Acetaminophen" is an example of a....
Definition
Generic name
Term
N-(4-hydroxyphenyl)-acetamide is an example of....
Definition
the chemical name
Term
Tylenol, liquiprin, tempra, tapanol are examples of the....
Definition
trade name
Term
What analogy has been used to describe the agonist, receptor, and drug-receptor complex?
Definition
A key in a lock
Term
The amount of a drug needed to produce 50% of a drug's potential max response is known as its...
Definition
potency
Term
___ is the drug’s ability to elicit maximum response at a given dose; drug’s ability to treat a disease
Definition
Efficacy
Term
Time it takes for a drug’s plasma concentration to decrease by 50% is known as....
Definition
half life
Term
What are some complicating factors when considering drugs impact on the elderly?
Definition
Differences in pharmokinetics, social isolation, poor nutrition, and reduced income
Term
___% of the elderly use over-the-counter medicaiton
Definition
70
Term
Be able to label
Definition
the parts of the cell
Term
True or False: Over time the proportion of a baby's body composed of fat increases and the proportion made up of water decreases
Definition
True
Term
True or False: Babies have slow or irregular peristalsis that may result in reduced absorption of a drug such that it may take longer for the medication to take effect
Definition
True
Term
Absorption in Children:
1. ___ absorption for intramuscular (IM) meds= much variation in circulation, Limited muscle mass, limited blood flow
2. .....absorption of oral meds
3. ___ absorption of topical meds
Definition
Slower; Decreased or increased; Faster
Term
True or false: children have mature livers at 6 months
Definition
False-2+ years
Term
True or false: Kidneys mature at about 2 years of age.
Definition
False. 4-12 months of age
Term
True or false: "White-coat compliance" is adhering to drug regimen around medical appointments
Definition
True
Term
True or false: Polypharmacy is concurrent use of many drugs; increases possibility for interaction between drugs
Definition
True
Term
True/false: The kidney actually gets larger with age
Definition
False. It gets smaller
Term
True/false: Drug-drug interactions refers to the negative effect of food that is eaten, preventing the desired effect of medication
Definition
False
Term
True/False: Karyorrhexis is when the nucleus condenses
Definition
False-it is when it fragments
Term
true/false: Cell necrosis is an active process.
Definition
False. Passive procress
Term
___ is when the nucleus condenses
Definition
Pyknosis
Term
___ is the dissolution of a cell nucleus, especially during mitosis.
Definition
Karyolysis
Term
True/false: it is always best to have a small therapeutic index
Definition
False. You want a large one
Term
True/false: Autolysis is when enzymes break down structures in cell after organ/organism dies; cell membrane stays intact but cytoplasm has vacuoles.
Definition
True
Term
___ is a passive event; cell membrane & internal organelles are destroyed
Definition
Necrosis
Term
___ is a active process; cell shrinks & breaks into pieces; series of events is activated by enzymes
Definition
Apoptosis
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