Term
|
Definition
|
|
Term
|
Definition
| prevents toxic metabolite from forming |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| may reverse hypotension and bradycardia |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| digoxin-specific Ab fragments |
|
|
Term
| digoxin-specific Ab fragments MOA |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| 100 mg deferoxamine binds 8.5 mg iron |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| ethylene glycol (antifreeze) |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
enzyme is busy metabolizing EtOH rather than poisons
fomipazole easier to use than EtOH |
|
|
Term
|
Definition
|
|
Term
|
Definition
opioid antagonist
duration of action may be shorter than that of the opioid being antagonized |
|
|
Term
|
Definition
|
|
Term
|
Definition
| react and inactivate eachother |
|
|
Term
| organophosphates (pesticides) |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| reverses cardiotoxic effects (wide QRS, hypotension) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
lasts 30-60 min
dose may need to be repeated |
|
|
Term
| effects of lead poisoning |
|
Definition
-affects neurocognitive function (hearing, fatigue, headache)
-affects developing CNS of fetus/children
-low dietary calcium
-iron deficiency |
|
|
Term
| Lead interferes with the action of what elements? |
|
Definition
|
|
Term
|
Definition
| through GI and respiratory tracts |
|
|
Term
| Lead is bound to _________ and distributed to _______ and ________. |
|
Definition
erythrocytes
soft tissue; bone |
|
|
Term
| lead level of concern for adults |
|
Definition
|
|
Term
| lead level of concern for children |
|
Definition
|
|
Term
| Where is the primary site of absorption of mercury where elemental form is absorbed? |
|
Definition
|
|
Term
| Where is organic alkylmercury absorbed? |
|
Definition
|
|
Term
| mercury poisoning symptom triad |
|
Definition
tremor
neuropsychiatric disturbance
gingivostomatitis |
|
|
Term
| What can mercury during pregnancy cause? |
|
Definition
mental retardation
cerebral palsy-like syndrome
(even in small amounts) |
|
|
Term
| guidelines for mercury consumption for pregnant women |
|
Definition
| no more than 12 oz. or 2 meals per week of fish of low mercury levels |
|
|
Term
| fish to avoid for moms, kids, and babies |
|
Definition
swordfish
king mackerel
tilefish
shark
tuna |
|
|
Term
| What fish are safe to eat? |
|
Definition
|
|
Term
|
Definition
| binds molecules and facilitates excretion |
|
|
Term
|
Definition
| GI intervention for poisoning if ingestion occurred within 1 hour |
|
|
Term
| How long does it take for Ipecac to work? |
|
Definition
|
|
Term
|
Definition
< 9 months old
pregnancy
no gag reflex
corrosive ingestion
hx of seizures |
|
|
Term
| When do you use gastric lavage? |
|
Definition
| ingestion within 4 hours (although better within 1 hour) |
|
|
Term
| gastric lavage contraindication |
|
Definition
| acidic or alkaline ingestion |
|
|
Term
| Do not give _________ to someone who will get charcoal. |
|
Definition
|
|
Term
| How do you give activated charcoal? |
|
Definition
1g/kg
keep giving every 4 hours |
|
|
Term
| What does activated charcoal not work on? |
|
Definition
| lithium, iron, potassium, ethanol, cyanide, strong acids and bases, hydrocarbons |
|
|
Term
| What is alkaline diuresis used for? |
|
Definition
effective in barbiturate and salicylate ingestions
giving bicarbonate helps enhance elimination of weak acids |
|
|
Term
| What is hemodialysis used for? |
|
Definition
| low molecular weight water soluble molecules (ex: salicylates, alcohols, amphetamines, phenobarbital, lithium, theophylline, thicyanate) |
|
|
Term
| What is hemoperfusion used for? |
|
Definition
barbiturates, salicylates, theophylline
essentially takes blood through charcoal filter and puts it back in the body |
|
|
Term
| What do you need to remember when treating a possible poisoning/overdose? |
|
Definition
TREAT THE PATIENT FIRST, THEN THE POISON!
ABCs: airway, breathing, circulation |
|
|
Term
| most common causes of death from poisoning |
|
Definition
aspiration
respiratory arrest
hypotension
hypovolemia
cardiac arrhythmias
hypoxia |
|
|
Term
| What types of drugs more readily cross the placenta? |
|
Definition
| lipophilic and smaller drugs |
|
|
Term
|
Definition
| controlled studies failed to show risk in 1st trimester |
|
|
Term
|
Definition
| no studies done in women, but studies done in animals showed no teratogenic effects |
|
|
Term
|
Definition
risk in animals
no studies in women performed
no one knows
benefits must outweigh risks |
|
|
Term
|
Definition
evidence of risk in humans
benefits must outweigh risks |
|
|
Term
|
Definition
| completely contraindicated |
|
|
