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PNUR 121 key terms chap. 04
what happens after a drug has been administered
15
Medical
Undergraduate 1
05/25/2009

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Term
absorption
Definition
the process of moving a drug across body membranes
Term
agonists
Definition
drugs that are capable of binding with receptors in order to cause a cellular response
Term
antagonist
Definition
drug that blocks the response of another drug
Term
biotransformation
Definition
the chemical conversion of drugs from one form to another that may result in increased or decreased activity
Term
distribution
Definition
the process of transporting drugs through the body
Term
excretion
Definition
the process of removing substances from the body
Term
first-pass effect
Definition
a mechanism whereby drugs are absorbed across the intestinal wall and enter into the hepatic portal circulation that carry blood directly to the liver
Term
half-life
Definition
(t1/2) the length of time required for a drug to decrease its concentration in the plasma by one-half of the original amount
Term
metabolism
Definition
the sum total of all chemical reactions in the body or an organ
Term
pharmacodynamics
Definition
the study of how the body responds to drugs and natural substances
Term
pharmacokinetics
Definition
the study of how drugs are handled by the body
Term
potency
Definition
the power or strength of a drug at a specified concentration or dose
Term
prodrugs
Definition
drugs that become more active after they are metabolized
Term
receptor
Definition
the structural component of a cell to which a drug binds in a dose-related manner to produce a response
Term
receptor theory
Definition
a cellular mechanism by which most drugs produce their effects
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