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Placenta and Fetus
VM 608 Final
26
Veterinary Medicine
Professional
05/01/2012

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Term
Placenta Physiology
Definition
there is no actual mixing of blood
passing of nutrients and gasa
acts as endocrine gland and produces HCG, progesterone, estrogen, prostaglandin
Term
Placenta Species Variation
Definition
Ruminants-cotyledonary
Carnivores-zonary
Pigs and Horses- diffuse
Primate and Rodents-discoid
Term
Adventitial Placentation
Definition
incidental finding in ruminants
red plaques that extend from cotyledons
compensatory mechanism for inadequate development of placentomes (acquired or congenital)
Term
Mineralized Yolk Sac Remnant
Definition
incidental finding in horse
yolk sac remnant on umbilical cord
becomes mineralized
Term
Amniotic Plaques
Definition
incidental findings in bovine
multiple, white raised circulate plaques present on fetal side
stratified squamous keratinizing epithelium
Term
Hippomane
Definition
incidental finding in horse
rubbery flattened large discs
end result of aggregation of sediments of allantoic fluid
Term
Fetal Mummification
Definition
fetus dies and is not expelled
fetus dehydrates, becomes firm, and discolored by hemoglobin
due to twinning, BVB, trichomoniasis, canine herpesvirus, torsion, parvovirus
tissue is well preserved
Term
Fetal Maceration
Definition
liquefaction of fetus due to bacterial infection
associated endometritis/pyometra
tissue is autolytic
Term
Brucella canis
Definition
causes early embyronic death, abortion, neonatal death
causes placentitis, pneumonia, hepatitis, endocarditis
causes orchitis, epididymitis, prostatitis
Term
Canine Herpes Virus 1
Definition
fetal/neonatal fatal hemorrhagic disease
neonate less than 2 weeks old
disseminated necrosis and hemorrhage of organs
Term
Canine Parvovirus
Definition
affects fetus/neonate less than 6 weeks old
causes myocarditis, panleukopenia
Term
Brucella abortus
Definition
zoonotic, seen in cows
reportable
causes abortion with spread through birth fluids and milk
tends to persist
bacteremia from earlier infection recurs during parturition and sheds it in colostrum
late gestation abortion
thickened intercotyledonary area with edema and fibrinonecrotic inflammation of placenta
see pneumonia in fetus
Term
Leptospira interrogans
Definition
may cause abortion in last trimester
interstitial nephritis and necrotizing hepatitis of fetus
find organism in kidney and antibodies in fetal fluids
few lesions on placenta
Term
Neospora caninum
Definition
major cause of abortion in cow at 5-6 months
encephalitis, myositis, myocarditis of fetus
cotyledonary necrotizing placentitis
bovine expels autolyzed fetus in last trimester
Term
Mycotic Abortion
Definition
Aspergillus fumigaus, Zygomycetes
sporadic
due to forestomach ulceration and hematogenous spread
late term abortion
leathery placenta with necrotic cotyledons
+/- fetal skin lesions
placenta often firmly retained
Term
Toxoplasma gondii
Definition
affects sheep, goats
if infected early in pregnancy=resorption
if infected late in pregnancy=abortion
focal malacia of white matter in fetus
foci of necrosis in multiple organs of fetus
multifocal white cotyledonary necrosis of placenta
Term
Mare Reproductive Loss Syndrome
Definition
due to eastern tent caterpillar that feeds on wild cherry tree
causes early and late fetal loss
uveitis, pericarditis, encephalitis of fetus
possibly due to toxin and then secondary bacterial infection
or possibly due to hairs of ETC break gastric mucosa and causes bacteremia
Term
Red Bag Delivery
Definition
premature separation of chorio-allantois
emergency because it disrupts foal's oxygen supply before delivery
caused by fescue grass contaminated with endophyte, mycotoxin
remove from pasture 300 days before gestation
Term
Fescue Toxicity
Definition
classic signs in pregnant mare:
agalactia
prolonged gestation
dystocia
placental thickening/edema
infertility
Term
Equine Herpes Virus 1
Definition
important cause of abortion in horses
abortion after 7 months
firm heavy lungs, necrotic hepatitis in fetus
EHV 3 & 4 produce similar sporadic abortions
Term
SMEDI
Definition
occurs in swine
S-stillborn
M-mummification
E-early embryonic
D-death
I-infertility
due to porcine parvovirs, PRRS, PCV-2, enterovirus
Term
Bovine Viral Diarrhea
Definition
pestivirus
fetus less than 5 months=abortion, mummy, malformation
fetus at 5 months=cerebellar hypoplasia, microphtalmia, hypotrichosis, arthrogryposis
fetus older than 5 months= live calves with immunity
Term
Acardiac Monster
Definition
bovine amorphous globosus
structure covered with hair as remnant of twin fetus
attached to placenta of normal twin by a stalk
Term
Arthrogryposis
Definition
persistent flexure/contraction of one or more joints
atrophy of appendicular muscle due to CNS disorder
hereditary, viral, toxins, intrauterine crowding
Term
Cyclops
Definition
occurs in sheep
Malformation of the midline
Due to plant toxin of Veratrum californicum
Abnormal gene expression so the splitting of the eyes does not occur
Term
Anasarca
Definition
occurs in cattle
Accumulation of fluid in the fetus and connective tissue
Pulmonary hypoplasia
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