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Pituitary Drugs
moas and indications
31
Pharmacology
Undergraduate 3
11/07/2014

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Term
Pituitary Drug Uses
Definition
1. replacement therapy in hormone deficiency
2. diagnostic aids to determine hypo-hyper function of specific hormonal function
Term
Cosyntropin
Definition
1. used to diagnose adrenal dysfunction and imitate the function of ACTH in body
2. when cosyntropin is administered and adrenal glands fail to increase serum cortisol levels, the pt is diagnosed with primary adrenocortical insufficiency or Addison's disease
Term
When Cosyntropin is administered and adrenal glands fail to increase serum cortisol levels the pt is diagnosed with
Definition
primary adrenocortical insufficiency or Addison's disease
Term
Addison's disease is treated with
Definition
exogenous cortisol.
Term
Cortisol has ________ effects and promotes _________________ which can result in ________ and ______________.
Definition
antiinflammatory; renal retention of sodium; edema; hypertension
Term
When administering octreotide (Sandostatin) to a patient, it is most important for the nurse to assess
Definition
blood sugar - ocreotide may cause alterations in blood glucose levels; closely monitor blood glucose during drug therapy
Term
Nursing Implications: - ACTH

Cosyntropin/Cortrosyn
Definition
1. IM, SC, IV forms, gel and repository forms
2. follow directions carefully for administration
3. maintain adequate hydration
4. decrease sodium and potassium intake
5. avoid vaccinations during drug therapy
Term
Nursing Implications - ACTH

Cosyntropin/Cortrosyn - therapeutic responses
Definition
1. Cosyntropin should eliminate pain associated with inflammation and produce increased comfort and muscle strength in pts with multiple sclerosis
Term
Somatropin/Somatrem - indications
Definition
1. recombinantly made growth hormone (GH)
2. stimulate skeletal muscle growth in pts w/ deficient GH, such as hypopituitary dwarfism
3. should increase growth in children - keep journal
Term
Ten year old N. has begun somatrem therapy. Wants to skip follow-up.
Definition
She should keep to monitor therapeutic effects and adverse effects. Adverse effects could include altered glucose levels, thyroid, and bone problems.
Term
octreotide (Sandostatin)
Definition
1. reduces diarrhea caused by carcinoid tumors that secrete (VIP) vasoactive intestinal polypeptide
2. reduces flushing and potential life-threatening hypotension that may occur with a carcinoid crisis.
Term
Nursing Implications:
octreotide (Sandostatin)
Definition
1. may impair gallbladder function - report abdominal pain
2. use with caution in pts with renal impairment and all types of diabetes
3. monitor glucose levels in pts with diabetes, and even in those who do not have diabetes
4. can be given IV, IM, or SC
5. should reduce symptoms of carcinoid crisis
Term
Vasopressin and desmopressin
Definition
1. used to treat diabetes insipidus
2. vasopressin: powerful vasoconstrictor used for hypotensive emergencies, GI bleeding, and pulseless cardiac arrest
3. Desmopressin: Used for dose-dependent treatment of blood disorders; also used for nocturnal enuresis
Term
Desmopressin/vasopressin - therapeutic responses
Definition
1. reduce severe thirst
2. decrease urinary output
Term
Nursing Implications:
Desmopressin/Vasopressin

Interactions
Definition
1. Lithium
2. alcohol
3. democlocycline
these reduce desmopressin effects
Term
desmopressin/vasopressin

pt. teaching
Definition
provide specific instructions for nasal spray forms of vasopressin
Term
A pt who is on vasopressin therapy calls to say he is not improving as expected. Further questioning reveals he has not stopped drinking beer.
Definition
Pt should be told to stop drinking because it reduces the effect of vasopressin
Term
Nursing Implications
Pituitary drugs
Definition
1. Obtain thorough nursing assessment and medication history
2. assess for contraindications specific to each drug
3. assess medication history for possible interactions
Term
Nuring Implications II
Pituitary drugs
Definition
1. rotate injection sites
2. do not discontinue drugs abruptly
3. do not take OTC products w/o checking with provider
4. adverse effects specific to individual drug
Term
Follicle stimulating hormone (FSH)
Definition
mentropins
Term
antidiuretic hormone
Definition
desmopressin
Term
adrenocorticotropic hormone
Definition
cosyntropin
Term
oxytocin
Definition
pitocin
Term
growth hormone
Definition
somatotropin
Term
A pt will be receiving somatropin. The nurse expects the pt has which disorder?
Definition
Hypopituitary dwarfism

Somatropin is human growth hormone that is used in the treatment of dwarfism.
Term
Cosyntropin is used for
Definition
the diagnosis of adrenocortical insufficiency
Term
otreotide is used for
Definition
esophageal varices
Term
vasopressin is indicated for
Definition
septic shock
Term
Somatropin
Definition
1. indicated in treatment of growth failure due to inadequate growth hormone secretion
2. used for pts with HIV infection with wasting or cachexia in conjunction with antiviral therapy
3. Preg. category B or C - depending on manufacturer
4. contraindicated in pts with closed growth plates, pts with tumors, pts with acute illness
5. adverse effects: headache, injection site reactions, muscle pain, hypoglycemia or hyper glycemia.
6. do not shake product.
Term
Otreotide
Definition
1. useful in alleviating certain symptoms of carcinoid tumors stemming from the secretions of VIP
2. symptoms include severe diarrhea, flushing, potentially life-threatening hypotension associated with a carcinoid crisis
3. treatment of esophageal varices
4. adverse effects: may impair gallbladder function and needs to be used with caution in pts with renal impairment. It may affect glucose regulation and severe hypoglycemia may occur in type I diatetic pts. causes hyperglycemia in type II.
Term
Vasopressin
Definition
1. used to prevent or control polydipsia (thirst), polyuria, and dehydration in pts with diabetes insipidus caused by deficiency of ADH.
2. also used to control various types of bleeding (GI hemorrhage), and in pulseless arrest and vasodilatory shock.
3. contraindicated in pts with known hypersensitivity
4. Preg. category C
5. administer w/caution in pts w/ seizure disorders, asthma, cardiovascular disease, renal disease
6. IV infiltration may lead to severe vasoconstriction and localized tissue necrosis...watch for any signs of infiltration and use central venous access device when possible
7. available as a nasal spray or injection for IM or IV use
8. when used to treat septic shock, it is given by continuous IV infusion
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