Term
| Feline Acromegaly Signalment |
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Definition
male cats
mixed breed
mean age 10 years |
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Term
| Feline Acromegaly Effects |
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Definition
due to effects of growth hormone
increased protein synthesis
decreased protein catabolism
release of fatty acids
decresed carbohydrate utilization
impaired glucose uptake/transport |
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Term
| Feline Acromegaly Clinical Findings |
|
Definition
PU/PD
insulin resistance
Polyphagia
Organomegaly
Prognathia
heart murmur
large head
macroglossia
CNS signs |
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Term
| Feline Acromegaly Lab Findings |
|
Definition
hyperglycemi/glucosuria
protienuria
hyperproteinemia
azotemia
hypercholesterolemia
erythrocytosis
increased ALT
ketonuria
increased ALP |
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Term
| Feline Acromegaly Radiographic Findings |
|
Definition
hepatomegaly
cardiomegaly
renomegaly
spondylosis
arthropathy |
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Term
| Feline Acromegaly Diagnostics |
|
Definition
UA, CBC, Chemistry
Rads
US
T4
Adrenal function testing
Stomatomedin C is most reliable test
Glucose suppression test
CT Scan or MRI of pituitary gland |
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Term
| Feline Acromegaly Treatment |
|
Definition
radiation
surgery
medical therapy for secondary problems
bromocriptine
octerotide |
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Term
|
Definition
caused by progesterone therapy or endogenous progesterone
progesterone stimulates GH secretion from ductular epithelium of the mammary gland
treatment is by ovariohysterectomy or withdrawal of progesterone therapy |
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|
Term
|
Definition
congenitl in dogs
failure of pituitary development
TSH deficiency
ACTH deficiency
GH deficiency |
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Term
| Pituitary Dwarfism Signalment |
|
Definition
most common in German Shepherd
short in stature
have puppy coats |
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Term
|
Definition
growth retardation
failure of dental eruption
delayed growth plate closure
lack of intelligence
soft, cotton-like coat texture
signs of hypoadrenocorticism, hypothyroidism |
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Term
| Pituitary Dwarfism Diagnostics |
|
Definition
urinalysis
CBC
Chemistry
Bile Acids
Abdominal imaging
arterial blood gases
TLI
endocrine testing
measurement of GH is difficult because secretion is episodic
GH stimulation testing
insuline like growth factor 1 assay
measure thryoid, TSH, and ACTH stim test |
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Term
| Pituitary Dwarfism Treatment |
|
Definition
no canine GH available
porcine and human GH has been used
dogs can develop antibodies to GH
diagnosis is usually too late for treatment to be sucessful
thyroid hormone replacement
glucocorticoid and mineralocorticoid replacement |
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Term
| Central Diabetes Insipidus |
|
Definition
lack of AVP production/secretion
may be partial or complete
any disturbance of hypothalamus/pituitary is a potential cause |
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|
Term
|
Definition
aka antidiuretic hormone
aka arginine vasopressin
synthesized and secreted by neurohypophysis
includes nuclei in hypothalamus which terminate in pituitary |
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Term
|
Definition
very small reduction is plasma osmolality causes ADH secretion due to CNS osmoreceptor effect
larger drop in ECF volume causes similar amount of ADH secretion due to baroreceptor effect, angiotensin-aldosterone system
ADH secretion stimualated by pain, nausea, vomiting, anesthesia, some drugs
ADH secretion inhibited by alcohol and drugs |
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Term
| Central Diabetes Insipidus Signalment |
|
Definition
dogs/cats
congenital <1 year
acquired at any age |
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Term
| Central Diabetes Insipidus Diagnostics |
|
Definition
don't do a test unless you rule out renal failure and other causes of PU/PD
urinalysis, urine must be dilute
normal CBC
normal chemistry
negative urine culture
normal urinary system, normal adrenal glands, normal liver in ultrasound |
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Term
| Central Diabetes Insipidus Clinical Signs |
|
Definition
PU/PD
Incontinence sometimes |
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Term
| Central Diabetes Insipidus Treatment |
|
Definition
DDAVP
eye drops with DDAVP or oral
treatment is not always required if the owners can deal with the PU/PD
make sure water is always available
monitor for dehydration
monitor for urinary tract infection |
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