Term
| Percentage of calcium bound to plasma protein and that is free |
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Definition
45% bound to plasma protein
55% of free calcium (1.2-1.5 mM) |
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Term
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Definition
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Term
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Definition
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Term
| Effect of hydrogen concentration on free calcium concentration |
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Definition
- acidemia (increase H) leads to increases in plasma free calcium (H takes up spots on plasma proteins)
- alkalemia (decrease H) leads to decreases in plasma free calcium
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Term
| Main site of calcium reabsoption |
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Definition
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Term
| Mechanism of calcium reabsorption in TAL |
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Definition
| calcium via paracellular channels in tight junctions (driven by positive lumen potential) |
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Term
| Mechanism of reabsorption at PCT and DCT |
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Definition
- on lumenal side, calcium channel and paracellular transportation
- on blood side, Ca/Na transport puts calcium into blood
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Term
| Main site of physiological control of calcium levels |
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Definition
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Term
| Distribution of phosphate |
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Definition
- 85% bone
- 15% ICF
- less than 0.5% ECF
- 10% of this plasma protein bound
- can buffer H
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Term
| Main site of reabsoprtion of phosphate |
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Definition
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Term
| Channels that reabsorb phosphate |
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Definition
- Na/P cotransport at tubular lumen side
- phosphate/organic anion antiport put phosphate into blood
- PTH inhibits this channel via G coupled protein
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Term
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Definition
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Term
| site of reabsorption of Magnesium |
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Definition
TAL (reab. inh. via loop diuretics)
PCT 30%
DCT 5%
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