Term
Absolute Refractory Period |
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Definition
Membrane cannot produce another AP because Na+ channels are inactivated |
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Term
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Definition
Transport of digestion products across intestinal epithelium into blood |
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Term
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Definition
- Most widely used neurotransmitter - Used by ALL preganglionic neurons in ANS - Synapses called cholinergic |
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Term
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Definition
Wave of MP change that sweeps along the axon from soma to synapse. - Wave is formed by rapid depolarization of the membrane by Na+ influx; followed by rapid re-polarization by K+ efflux |
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Term
Action Potential: all or none |
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Definition
When MP reaches threshold an AP is irreversibly fired: - because positive feedback opens more and more Na+ channels - shortly after opening, Na+ channels close and become inactivated until re-polarization |
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Term
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Definition
Moves compounds AGAINST a concentration gradient; requires energy and transporter |
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Term
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Definition
Transport of molecules against a concentration gradient - ATP is required - A carrier protein is required |
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Term
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Definition
Membranes are glued together by proteins that pass through both membranes and attach to cytoskeleton |
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Term
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Definition
Two types of α (α1 and α2) Two types of β (β1 and β2) - All act using G-proteins and second messenger systems. - β receptors use cAMP. - α receptors use a Ca2+ second messenger system. |
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Term
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Definition
Moves materials AWAY from cell body - uses the molecular motor kinesin |
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Term
Ascending Tracts Of Spinal Cord |
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Definition
- Convey sensory information from receptors in the skin, muscles, joints, and organs - Crossover of information (contralateral) may occur in the spinal cord or in the medulla. |
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Term
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Definition
Integrate NS activity - located entirely inside CNS |
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Term
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Definition
Located in the head, neck, and abdomen as well as in chains along either side of the spinal cord |
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Term
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Definition
Has 2 neurons 1. Preganglionic neurons: originate in the midbrain or hindbrain or from the thoracic, lumbar, or sacral spinal cord 2. Postganglionic neurons: originate in ganglion |
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Term
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Definition
Single, long extension off cell body that conducts nerve impulses to other cells |
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Term
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Definition
- Moves soluble compounds TOWARD nerve endings ~ via rhythmic contractions of axon |
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Term
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Definition
Moves large and insoluble compounds bidirectionally along microtubles; very fast |
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Term
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Definition
Dendrite and axon arise from opposite ends of cell body
Ex. RETINAL neurons |
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Term
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Definition
Located in left inferior frontal gyrus - Broca’s aphasia involves slow, poorly articulated speech. There is no impairment in understanding. - Controls motor aspects of speech ~ Only the production of speech is affected. |
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Term
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Definition
Moves large molecules and particles across plasma membrane - This occurs by endocytosis and exocytosis Exocytosis: moving from cytoplasm to OUTside of the cell Endocytosis: moving from outside of the cell to INside of cytoplasm |
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Term
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Definition
Refer to how axon's properties affect its ability to conduct current - Includes high resistance of cytoplasm ~ RESISTANCE DECREASES AS AXON DIAMETER INCREASES - Current leaks out through ion channels |
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Term
Cardiac (Myocardial) Tissue |
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Definition
- Short, branched, grouped - Involuntary - Intercalated discs which provide mechanical and electrical connections - NOT individually controlled - Single nucleus |
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Term
Carrier-Mediated Transport |
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Definition
Molecules too large and polar to diffuse are transported across membrane by protein carriers |
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Term
Carrier-mediated transport |
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Definition
Involves specific protein transporters |
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Term
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Definition
Contains nucleus and it is the metabolic center |
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Term
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Definition
Nutritional center and makes macromolecules - Groups of cell bodies in CNS are called nuclei - Groups of cell bodies in PNS are called ganglia |
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Term
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Definition
How cells communicate with each other - Some use GAP JUNCTIONS through which signal pass directly from 1 cell to the next - To respond to a CHEMICAL SIGNAL, a target cell must have a receptor protein for it |
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Term
Central Nervous Systen (CNS) |
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Definition
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Term
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Definition
The outer region of the cerebrum is composed of 2-4mm gray matter with underlying white matter - Characterized by RAISED FOLDS called GYRI separated by DEPRESSED GROUPS called SULCI - Each hemisphere is divided by deep sulci into 5 lobes |
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Term
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Definition
Each side of the precentral gyrus controls movements on the opposite side of the body - Communication between the sides occurs through the corpus callosum; this is severed in severe forms of epilepsy - RIGHT HEMIS: visuospacial tasks, recognizing faces, composing music, arranging block, reading maps - LEFT HEMIS: language, speech, writing, calculations |
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Term
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Definition
Derived from the telencephalon - Largest potion of the brain (80%) - Responsible for higher mental functions - Consists of a right and left cerebral hemisphere connected internally by the corpus callosum |
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Term
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Definition
Synaptic cleft separates terminal bouton of presynaptic from postsynaptic cell - NTs are in synaptic vesicles |
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Term
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Definition
Use acetylcholine as NEUROTRANSMITTER |
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Term
Conduction in Myelinated Axon |
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Definition
Ions can't flow across myelinated membrane - Thus no APs occur and no current leaks; this increases current spread - APs only occur at nodes, VG Na+ channels are present only at nodes - Fast because APs skip from node to node = SALTATORY CONDUCTION |
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Term
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Definition
- Has lots of extracellular material deposited in space between its cells - Includes connective tissue proper, cartilage, bone and blood - Loose connective tissue consists of collagen (fibrous proteins) and tissue fluid Ex: dermis of the skin |
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Term
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Definition
Dense regular connective tissue is packed with fibers of collagen: - Can be regularly arranged as in tendons - Irregularly oriented as in capsules, sheaths |
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Term
Connective Tissue: Adipose |
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Definition
Specialized for fat synthesis, breakdown and storage |
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Term
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Definition
Formed as concentric circles of calcified material.
Contains 3 cell types: - Osteoblasts: bone forming cells - Osteocytes: trapped, inactive osteoblasts - Osteoclasts: the bone resorbing cells |
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Term
Connective Tissue: Cartilage |
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Definition
- Specialized for support, protection - Made of chondrocytes and elastic extracellular material - Serves as precursor for bone - Forms articular surfaces for joints |
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Term
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Definition
- Part of the PNS - Nerves that arise directly from nuclei in the brain - 12 pairs - Most are mixed nerves with both sensory and motor neurons - Those associated with vision, olfaction, and hearing are sensory only - Cell bodies of these neurons are not in the brain but in ganglia located near the sensory organ. |
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Term
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Definition
Highly branched extensions off cell body and they receive inputs from other neurons |
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Term
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Definition
Occurs when MP becomes more POSITIVE |
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Term
Descending Tracts Of Spinal Cord |
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Definition
TWO MAJOR GROUPS 1. Corticospinal or pyramidal: descend directly without synaptic interruption from the cerebral cortex to the spinal cord ~ Cell bodies of these neurons are located in the precentral gyrus and superior frontal gyrus.
2. Extrapyramidal tracts: originate in the brain stem and are controlled by the motor circuits of the corpus striatum, substantia nigra, and thalamus ~ Symptoms of Parkinson disease reveal the importance of these tracts for initiating body movements, maintaining posture, and controlling facial expression. |
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Term
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Definition
Button two membranes together |
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Term
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Definition
Random motion of molecules |
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Term
Diffusion Through Cell Membrane |
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Definition
- Cell membranes are impermeable to charged and most polar compounds - Charged molecules must have an ion or channel or transporter to move across membrane - Non-polar compounds readily diffuse through cell membrane. Also some small molecules such as CO2 and H2O. Gas exchange occurs this way. |
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Term
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Definition
2 major Dopamine systems in brain: -Nigrostriatal Dopamine System: originates in the substantia nigra and is involved in motor control ~ degeneration of this system causes Parkinson's
-Mesolimbic Dopamine System: Involved in behavior and emotional reward. ~ most addictions activate this system - over activity contributes to schizophrenia which is treated by anti-dopamine drugs |
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Term
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Definition
Excitatory Postsynaptic Potentials - Graded in magnitude - Have NO threshold - Cause depolarization - Summate - Have NO refractory period |
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Term
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Definition
Depolarization flows from presynaptic into post synaptic cell through channels called gap junction - formed by connexin proteins - found in smooth and cardiac muscles, brain and glial cells |
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Term
Electroencephalogram (EEG) |
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Definition
Electrodes on the scalp detect synaptic potentials produced by cell bodies and dendrites in the cerebral cortex - four patterns usually seen: 1. Alpha waves: active, relaxed brain. Seen most in frontal and parietal lobes 2. Beta waves: produces with visual stimulation and mental activity. Seen most in frontal lobe 3. Theta waves: seen during sleep; most from occipital and temporal lobes 4. Delta waves: also seen in sleep, from all over the cerebrum |
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Term
Emotions Controlled By The Limbic System |
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Definition
- Aggression: areas in the amygdala and hypothalamus - Fear: amygdala and hypothalamus - Hunger/satiety: hypothalamus - Sex drive: the whole system - Goal-directed behaviors: hypothalamus and other regions |
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Term
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Definition
Cells secrete chemical regulators that move through blood stream to distant target cells |
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Term
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Definition
- Lines and covers body surfaces - Consists of cells that form membranes and glands - Regularly replaced - Squamous: flat - Columnar: tall - Cuboidal: cubed |
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Term
Epithelial Tissue Characteristics |
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Definition
- Simple membranes are one cell thick and are specialized for transport - Stratified has a number of layers and are specialized for protection - Cells are joined by junctional complexes, which increase strength and create a barrier - Separated from underlying tissue by basement membrane |
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Term
Epithelial Tissue: Keratin |
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Definition
- Non keratinized stratified squamous consists of living cells - Keratinized stratified squamous has outer layer of dead cells ~ cells contain water resistant keratin |
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Term
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Definition
Describes voltage across cell membrane if only 1 ion could diffuse - If membrane permeable only to K+, it would diffuse until it reaches its equilibrium potential |
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Term
Examples of Extrinsic control |
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Definition
#1: Body temperature is controlled by antagonistic effects of sweating and shivering
#2: Hormones control blood glucose levels |
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Term
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Definition
- Derived from epithelial cells - Secrete onto epithelium via ducts - Can be simple tubes or clusters called acini whose secretion is controlled by surrounding myoepithelial cells
Exo: via ducts Endo: blood stream |
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Term
Extracellular Environment |
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Definition
Includes all constituent of body outside cells
- 67% of total body H2O is inside cells (intracellular) - 33% is outside the cells (extracellular) |
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Term
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Definition
Meshwork of collagen and elastin fibers linked to molecules of gel-like ground substance and to plasma membrane Integrins |
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Term
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Definition
Passive transport down concentration gradient by carrier proteins |
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Term
Frontal and Parietal Lobes |
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Definition
Separated by central sulcus - Precentral gyrus is located in the frontal lobe and is responsible for motor control - Postcentral gyrus is in the parietal lobe and is responsible for somatesthetic sensation (coming from receptors in the skin, muscles, tendons, and joints) |
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Term
Functional Magnetic Resonance Imaging (fMRI) |
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Definition
Visualizes increased neuronal activity in different brain regions indirectly by looking at blood flow - release of the neurotransmitter glutamate increases vasodilation of blood vessels in the area |
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Term
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Definition
Are part of 2nd messenger pathway in many cells. - Contain 3 subunits whose components dissociate when a cell surface receptor is activated - A subunit binds to an ion channel or enzyme, changing their activity |
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Term
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Definition
Most common NT in brain - Inhibitory, opens Cl- channels - These degenerate in Huntington's disease |
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Term
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Definition
Link intracellular and extracellular compartments |
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Term
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Definition
Maintenance of a state of dynamic constancy in which conditions are stabilized about and below a physiological set point |
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Term
Homeostasis: Negative Feedback & how it is controlled |
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Definition
Sensor: Detects deviation from set point Integrating center: determines response Effector: produces response
- Negative feedback loops control blood pressure - Hormonal control of blood glucose |
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Term
Homeostasis: Positive Feedback & how it is controlled |
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Definition
Positive feedback amplifies changes - Involved in producing blood clots - In females it is used to create the LH surge that causes ovulation - Positive feedback between uterus and oxytocin secretion occurs during labor |
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Term
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Definition
Have higher pressure than plasma |
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Term
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Definition
MP becomes more negative than RMP |
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Term
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Definition
Have higher osmotic pressure and are osmotically active |
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Term
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Definition
Have lower osmotic pressure than plasma |
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Term
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Definition
Have lower osmotic pressure |
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Term
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Definition
Inhibitory Postsynaptic Potentials - If MP in postsynaptic cell reaches threshold at the axon hillock, a new AP is generated - GABA and glycine produce IPSOs |
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Term
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Definition
Mediates attachment to the cell and its tissues surroundings |
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Term
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Definition
Have same osmolality as plasma |
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Term
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Definition
Have same osmotic pressure |
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Term
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Definition
- Group of brain regions responsible for emotional drives - Areas of the cerebrum included: cingulate gyrus, amygdala, hippocampus, septal nuclei, anterior insula - Hypothalamus and Thalamus are also in this system |
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Term
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Definition
TWO TYPES OF LONG TERM: - Non-declarative (explicit) includes memories of simple skills and conditioning - Declarative (implicit) includes verbal memories Amnesiacs have impaired declarative memory - Long-term memory requires a relatively permanent change in neuron chemical structure and synapses |
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Term
Magnetic Resonance Imaging (MRI) |
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Definition
Protons in tissues are aligned by powerful magnets. The chemical composition of different tissues results in difference in proton alignment - can be amplified using MRI contrast agents injected before imaging - shows clear definition between gray matter, white matter, and cerebrospinal fluid |
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Term
Mechanism of Action Potential: Depolarization |
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Definition
- At threshold, VG Na+ channels open - Na+ driven inward by its electrochemical gradient - This adds depolarization, opens more channels ~ termed a positive feedback loop - Causes rapid change in MP from -70 to +30 mV |
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Term
Mechanism of Action Potential: Depolarization & Re-polarization |
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Definition
Occur via diffusion - do NOT require active transport - after an AP, Na+/K+ pump extrude Na+, recovers K+ |
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Term
Mechanism of Action Potential: Re-polarization |
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Definition
- VG Na+ channels close; VG K+ channels open - Electrochemical gradient drives K+ outward - Repolarizes axon back to RMP |
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Term
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Definition
MP changes occur by ion flow through membrane channels: - K+ leakage channels are always open - Voltage gated (VG) channels are opened by ~ VG K+ channels are closed in resting cells ~ Na+ channels are VG; closed in resting cells |
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Term
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Definition
Difference in charge across membranes - Results in part from presence of large anions being trapped inside cell - Na+ is not permeable and is actively transported out |
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Term
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Definition
Measured by placing 1 electrode inside cells and 1 outside |
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Term
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Definition
LOWER CASE m - 1 mole of solute dissolved in 1 kg H2O |
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Term
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Definition
CAPITAL M - 1 mole of solute dissolved in 1L of solution ~ doesn't specify exact amount of H2O |
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Term
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Definition
Carry impulses out of CNS |
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Term
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Definition
Have many dendrites and one axon
Ex. motor neurons |
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Term
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Definition
- Specialized for contraction **skeletal, cardiac, smooth** |
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Term
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Definition
Uninsulated gap between adjacent Schwann cells is called the node of Ranvier |
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Term
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Definition
Gives membrane voltage needed to counteract concentration forces acting on an ion Ex = 61 log [Xout] z [Xin]
z=valence of the ion
Value of Ex depends on ratio of ion concentrations inside and outside cell membrane |
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Term
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Definition
- Consists of neurons and supporting (glial cells) - Specialed for conducting electrical signals **Have a cell body, dendrites, and axon** |
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Term
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Definition
Region of hight to low concentration |
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Term
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Definition
Gather and transmit information by: 1. Responding to stimuli 2. Producing and sending electrochemical impulses 3. Releasing chemical messages |
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Term
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Definition
- Promote fetal nerve growth - Required for survival of many adult neurons - Important in regeneration |
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Term
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Definition
Nicotinic: found in autonomic ganglia ~Stimulated by ACh ~Serve as ion channels Muscarinic: found in visceral organs ~Five types identified; can be stimulatory or inhibitory (opening K+ or Ca2+ channels) ~Use G-proteins and second messenger system |
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Term
Non-carrier mediated transport |
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Definition
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Term
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Definition
Used in PNS and CNS - In PNS is a sympathetic NT - In CNS affects general level of arousal ~ Amphetamines stimulate NE pathways |
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Term
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Definition
Total molatlity of a solution |
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Term
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Definition
Net diffusion of H2O across a selectively permeable membrane
- H2O diffuses down its concentration gradient until equal - H2O is less concentrated where there are more solutes ~ Solutes have to be OSMOTICALLY active: CANNOT freely move across membrane - Some cells have water channels (AQUAPORINS) to facilitate osmosis |
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Term
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Definition
Force that would have to be exerted to stop osmosis |
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Term
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Definition
Moves material through tiny spaces BETWEEN epithelial cells |
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Term
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Definition
Cells secrete regulatory molecules that DIFFUSE to nearby target cells |
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Term
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Definition
Preganglionic neurons come from the brain or sacral region of the spinal cord. ~ Also called the craniosacral division - They synapse on ganglia located near or in effector organs. ~ Called terminal ganglia |
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Term
Parasympathetic Functions |
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Definition
- Allows the body to “rest and digest” through the release of ACh from postganglionic neurons ~ Slows heart rate, dilates visceral blood vessels, increases digestive activities |
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Term
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Definition
Moves compounds down concentration gradient: requires NO energy |
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Term
Peripheral Nervous System (PNS) |
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Definition
Cranial and Spinal Nerves |
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Term
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Definition
Phase 1: Toxicity & metabolism on humans Phase 2: Effectiveness & toxicity on population Phase 3: Widespread of drug in diverse population Phase 4: Drug tested for other potential uses |
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Term
Positron Emission Tomography (PET) |
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Definition
Radioactively labeled deoxyglucose injected into the blood; emits gamma rays in active tissues - used to monitor cancer - used to study brain metabolism, drug distribution in the brain, and changes in blood flow following activity |
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Term
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Definition
GABA and glycine produce IPSPs - IPSPs dampen EPSPs making it harder to reach the threshold |
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Term
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Definition
Occurs when 1 neuron synapses onto axon or bouton of another neuron, inhibiting release of its NT |
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Term
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Definition
Na+/K+ Pump - Uses ATP to move 3 Na+ out and 2 K+ in against their gradients |
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Term
Protein carriers exhibit: |
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Definition
- Specificity: for single molecule - Competition: among substrates for transport - Saturation: when all carriers are occupied ~ this is called Tm (transport maximum) |
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Term
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Definition
Cell body sits along side of single process
Ex. sensory neurons |
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Term
Rate of Diffusion depends on: |
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Definition
1. Magnitude of its concentration gradient 2. Permeability of membrane to it 3. Temperature 4. Surface area of membrane |
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Term
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Definition
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Term
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Definition
Transports compounds out of urinary filtrate back into blood |
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Term
Regulatory mechanisms: Extrinsic control |
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Definition
Comes from outside of organ |
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Term
Regulatory mechanisms: Intrinsic control |
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Definition
Built into organ being regulated |
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Term
Relative Refractory Period |
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Definition
Occurs when VG K+ channels are open, making it harder to depolarize to threshold |
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Term
Reticular Activating System |
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Definition
-To fall asleep, we must tune out sensory stimuli. When awake, we are alert to sensory stimuli. - This depends on the activation and inhibition of the reticular activating system (RAS). ~ Includes the pons and reticular formation of the midbrain |
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Term
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Definition
Moves material toward cell body - uses the molecular motor dynein - viruses and toxins can enter CNS this way |
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Term
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Definition
1. Testable hypothesis about observation 2. Conduct experiments to test hypothesis 3. Conclude if experiment supports hypothesis 4. Natural phenomena based on proven hypothesis |
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Term
Secondary Active Transport |
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Definition
ATP needed for "uphill" (against gradient) movement of molecule or ion obtained from "downhill" (with gradient) transport of Na+ into cell |
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Term
Secondary Active Transport Terms |
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Definition
- Cotransport (symport): is secondary transport in same direction as Na+ - Countertransport (antiport): moves molecule in opposite direction to Na+ |
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Term
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Definition
May be ions (Ca++) or other molecules such as cyclic AMP (cAMP) or G-proteins |
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Term
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Definition
Conduct impulses into CNS |
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Term
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Definition
Involved in regulation of mood, behavior, appetite, and cerebral circulation - LSD is structurally similar - SSRIs are antidepressants Ex: prozac, zoloft, paxil, luvox |
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Term
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Definition
- Short-term memory involves a recurrent circuit where neurons synapse on each other in a circle. - Interruption of the circuit destroys the memory. There was no structural change. |
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Term
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Definition
- Striated - Voluntary (except for reflexes) - Fuses together in embryonic stages which makes it multi nucleated - Individually controlled |
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Term
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Definition
REM: rapid eye movement; state when dreams occur. Theta waves are seen here
NON-REM: also called resting sleep; divided into four stages, determined by EEG waves seen. Stages 3 and 4 are often called slow wave sleep, characterized by delta waves |
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Term
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Definition
When people first fall asleep, they enter NON-REM sleep and progress through the four stages -Then, a person ascends back up the stages of NON REM sleep to REM sleep ~ cycle repeats every 90 mins, people go through 5 per night ~ if allowed to awaken naturally, people usually do so during REM sleep |
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Term
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Definition
- Single nucleus - Not striated - Involuntary - Controlled by ANS |
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Term
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Definition
- Composed of white matter surrounding a gray matter core - The gray matter is arranged with a left and right dorsal horn and a left and right ventral horn. |
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Term
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Definition
- The white matter is composed of ascending and descending fiber tracts. - Arranged into six columns called funiculi - Ascending tracts are given the prefix spino- with a suffix that indicates the brain region it synapses on - Descending tracts are given the suffix -spinal, and the prefix indicates the brain region they came from |
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Term
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Definition
Part of the PNS - Nerves that arise directly from the spinal cord 31 pairs: 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, 1 coccygeal |
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Term
Supporting Cells (Glial Cells) |
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Definition
Provide physical and functional support for neurons
**5X more abundant than neurons** |
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Term
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Definition
PNS has Schwann and satellite cells - Schwann cells myelinate PNS axons
CNS has oligodendrocytes, microglia, astrocytes and ependymal cells - Each oligodendrocyte myelinates several CNS axons - Ependymal cells appear to be neural stem cells - Other glial cells are involved in NS maintenance |
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Term
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Definition
Preganglionic neurons come from the thoracic and lumbar regions of the spinal cord ~ Also called the thoracolumbar division |
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Term
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Definition
The sympathetic division activates the body for “fight or flight” through the release of norepinephrine from postganglionic neurons and the secretion of epinephrine from the adrenal medulla. ~ Prepares the body for intense physical activity in emergencies by increasing heart rate and blood glucose levels and by diverting blood to skeletal muscles |
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Term
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Definition
Functional connection between a neuron (pre) and another cell (post) - Synaptic transmission at chemical synapses is via neurotransmitters - Electrical synapses are rare in NS |
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Term
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Definition
1 neuron sends neurotransmitter messages to another cell via synapses |
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Term
Temporal, Occipital, Insula |
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Definition
Temporal: auditory centers Occipital: vision and coordination of eye movements Insula: encoding of memory and integration of sensory information with visceral responses; receives olfactory, gustatory, auditory, and pain information |
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Term
Testing of hypothesis includes: |
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Definition
- Experiment control groups - Quantative measures - Analysis of data with statistics |
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Term
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Definition
When plasma membranes can join together |
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Term
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Definition
Effect of a solution on osmotic movement of H2O |
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Term
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Definition
Moves material from 1 side to other of epithelial cells |
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Term
Transport Across Plasma Membrane |
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Definition
- Selectively Permeable: allows only certain kinds of molecules to pass |
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Term
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Definition
- Axons of POSTganglionic neurons have various swellings called varicosities that RELEASE neurotransmitter along the length of the axon. - They form “synapses en passant” in passing. - Sympathetic and parasympathetic neurons innervate the same tissues. |
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Term
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Definition
- Located in left superior temporal gyrus - Wernicke’s aphasia involves production of rapid speech with no meaning, called “word salad.” - Information about written words is sent by the occipital lobe. |
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Term
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Definition
Physiological altered by disease or injury |
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Term
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Definition
How the body works to maintain life |
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Term
X-Ray Computed Tomography (CT) |
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Definition
Looks at soft tissue absorption of X-rays |
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