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performed by head and jaws, draw fluid to mouth by tongue |
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performed by tongue and incisor teeth |
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Domestic animals aside from dogs and cats |
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draw liquid in by suction |
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How does mastication in the horse cause teeth to wear and turn into chisel-shaped grinding surfaces? |
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lateral movement of jaw, mastication occurs on one side at a time |
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vertical jaw movements, producing shearing action |
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Swallowing or deglutination center |
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formed by collection of nerve cells located on floor of 4th ventricle of brain and stimulated by afferent impules arising from receptors in posterior mouth, pharynx, and epiglottis |
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Bolus travels faster with _______ muscle in the esophagus |
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In the esophagus, a myenteric nerve plexus is present with what type of muscle? |
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Striated muscle in esophagus |
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found in circular and longitudinal muscle coat in most species |
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Smooth muscle is found (in relation to esophagus) |
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caudal portion of esophagus in some species |
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peristalic contraction of the esophagus elicited only by a swallowing movement |
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local esophageal stimulation by introduction of bolus or foreign body |
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If primary wave fails to pass the bolus |
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the bolus itself will initiate secondary wave |
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What two mechanisms induce increases in cystolic Ca2+ concentration? |
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Muscarinic receptor and smooth muscle depolarization |
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respiration is inhibited because the nasopharynx and trachea are closed |
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Na/Ca2+ spikes are needed to |
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move calcium back inot intracellular stores |
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Three motor zones of stomach |
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dorsal portion - reception and storage of contents and adaptions to volume |
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body - serves as mixing vat (saliva, gastric juice, and food) |
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gastric pump regulating propulsion of food past pyloric sphincter to duodenum |
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mixes injesta and delays passage of solid particles through pyloric sphincter |
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are retained under high pressure until reduced in size |
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Rate in which fluid contents leave the stomach |
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regulated by duodenal receptors responding to chemical composition of a meal |
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When stomach is distended |
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mechanoreceptors in wall are activated and vagal tone increases |
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mediates inhibitory control of gastric emptying |
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CCK receptors respond to _____ in duodenum and jejunum. |
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What types of gastric contents trigger slowing/inhibition of gastric emptying? |
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hypertonicity, acidity, irritants, excess carbs, lipids, and protein |
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High concentrations of ____ will ulcerate the duodenum. |
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High concentrations of H+ that can ulcerate the duodenum can be caused by |
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hypertonicity - causing a shift in fluid from plasma to lumen |
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Carnivores/omnivores vomit |
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Stimulation of the distal esophagus in a cow will |
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stimulate regurgitation of cud |
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Why does vomitus sometimes contain small intestinal contents? |
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initially during vomiting relex, proximal intestine retropels content into the stomach via reverse peristalisis |
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pharyngeal or gastric irritation |
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Mechanism of internal vomiting in ruminants |
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ejection of abomasal contents into forestomach |
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Instead of vomiting, horses |
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develop acute gastric dilatiation, which can lead to rupture of the stomach wall |
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Central control of vomiting occurs |
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chemoreceptor trigger zone is stimulated by chemicals such as morphine, apomorphine, cardiac glycosides, and CuSO4 |
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Reflex control of vomiting |
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conducted by vomiting center, and stimulated by GI afferents |
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Loss of H+ in the body due to vomiting can result in |
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Neural centers of the emetic mechanism are located in the ________. |
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when contents reflux back and forth between the esophagus and stomach |
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Entry of vomitus into trachea is prevented by |
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closure of the glottis and suspension of respiration |
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distal renal tubule will attempt to compensate leading to renal loss |
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digestive and absorptive functions |
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Digestion and absorption in the small intestine occurs by |
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mixing of luminal contents with pancreatic enzymes and bile, digestion of carbs, lipids, and proteins and maximal exposure to mucosa |
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As injesta moves through the duodenum --> jejunum --> ileum |
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contents are retained longer as it reaches each section |
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Longitudinal muscle function in small intestine |
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peristalsis - muscle contracts and inhibits circular muscle to widen the lumen ahead of the bolus |
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Segmentation - contracts to result in content mixing instead of forward movement |
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functions to break down stomach solids via retropulsion and further mixing of digesta |
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"housekeeping" occuring ~6-8 hrs to move contents out of small intestine and into cecum to ensure small bowel motility |
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3 phases of migrating myoelectric complex (MMC) |
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slow waves no action phase I, slow waves intermittent action potentials phase II, spike bursts of action potential phase III - resulting in strong peristaltic contractions |
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What initiates 'fed pattern of motility'? |
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feeding - goes directly into phase II like pattern with mixing, motility, and short distance peristalsis |
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inhibitory reflexes (pain/distention) |
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Small intestine is mediated by 2 reflexes |
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What is the primary site of microbial digestion in the horse? |
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MMC is not interrupted by the fed pattern in |
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Fed pattern of motility interrupts the MMC |
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Unlike the horse - sheep, ruminants, rodents, and lagomorphs |
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digesta back flows from colon into cecum |
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In the horse digesta moves from |
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cecum directly into colon |
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The ruminant's longer small intestine produces a digesta transit time _______ to that of the carnivore. |
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The fed pattern of the stomach is |
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Mid colonic pacemaker sends a wave |
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in both directions, however most move orally |
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Pacemakers in the proximal colon send waves |
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Spinal cord damage above the lumbosacral region results in |
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incontinenance induced by ileal outflow |
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Animals infected with stomach/intestinal parasites display altered motility which will ________ transit time |
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During parasitic infection MMC is reduced and replaced with MAPC - migrating action potential complex which results in |
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strong peristaltic contractions which move faster through the intestine |
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During infection/allergy hypertrophy of the muscular coat occurs |
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increasing strength of contractions |
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What resident immune cells are responsible for initiating the altered motility in parasitism or allergy? |
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During infection/allergy if there is an increase in intestinal secretions of water and electrolytes what results? |
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diarrhea - aimed to clear small intestine |
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If infected a 2nd time with parasites |
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immunological response triggers memory and altered motility and secretions take place more quickly |
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Primary and secondary infections are mediated by mucosal mast cells which secrete ________ and __________ during infection. |
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Mucosal mast cells bear receptors for |
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IgE creates turbulent effects including |
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partial degranulation of tissue and expulsion of worms |
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Mast cells degranulate by |
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Enterochromaffin-like cells can release |
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Endochromaffin-like cells act to regulate |
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As demonstrated in class with a screw and hard candy - by adding peaks and valleys |
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less pressure must be applied for crushing |
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