Term
Types of Fat Based on Processing Necessary for Optimum Digestion
and Absorption - Enzymatic Digestion and Micellar Solubilization
- Micellar Solubilization Only
- Enzymatic Hydrolysis Only
- Enzymatic Hydrolysis and Partial Micellar Solubilization
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Definition
- long chain fatty acid triglycerides
- cholesterol, fat-soluble vitamins
- medium/short-chain fatty acid triglycerides
- phospholipid
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Term
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Definition
| HYDROLYSIS (enzymatic digestion) AND MICELLAR SOLUBILIZATION |
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Term
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Definition
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Term
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Definition
| HYDROLYSIS (enzymatic) ONLY |
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Term
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Definition
| HYDROLYSIS (enzymatic) AND PARTIAL MICELLAR SOLUBILIZATION |
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Term
acid lipase - source
- preferred substrate
- positional specificity
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Definition
- saliva, stomach
- medium/short chain fatty acid TG's
- no
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Term
pancreatic lipase - source
- preferred substrate
- positional specificity
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Definition
- pancreas
- triglycerides
- yes (1, 1' positions)
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Term
bile salt stimulated lipase - source
- preferred substrate
- positional specificity
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Definition
- milk, pancreas
- medium/short chain fatty acid TG's
- no
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Term
phospholipase A2 - source
- preferred substrate
- positional specificity
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Definition
- pancreas
- phospholipid
- yes (2 position)
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Term
| EVENTS IN FAT DIGESTION AND ABSORPTION |
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Definition
- EMULSIFICATION
- HYDROLYSIS
- MICELLAR INCORPORATION
- ABSORPTION
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Term
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Definition
- Process begins in the stomach
- Acid Lipases (AL)
- Gastric mechanical activity
- Large oil droplets converted to smaller particles
- Increase in Surface Area
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Term
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Definition
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Term
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Definition
| PANCREATIC LIPASE AND TRIGLYCERIDE DIGESTION |
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Term
| PROPERTIES OF PANCREATIC LIPASE |
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Definition
- Secreted in ACTIVEform
- Inhibited by high concentration of Free Fatty Acids
- pH optimum 6-7 (normal duodeno-jejunal pH)
- Interfacial enzyme; inhibited by Bile Salts
- Positional Specificity; removes fatty acid from the 1 and 1’ positions only
- Acid labile enzyme; inactivated at pH < 3
- Secreted in great excess; safety factor
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Term
Mixed Micelle Components [image] |
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Definition
Bile Acids
Free Fatty Acids
Monoglycerides |
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Term
Bile Acids
Free Fatty Acids
Monoglycerides |
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Definition
| Primary Solutes: Major Components |
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Term
Cholesterol
Fat Soluble Vitamins Xenobiotics
Drugs |
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Definition
Secondary Solutes: Minor Components “Dissolved” in “Oily” Core |
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Term
Liquid Phases During Digestion in Small Bowel Components of the
“Oil” Phase |
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Definition
- triglycerides
- diglycerides
- cholesterol
- fat soluble vitamins
- other very lipophilic compounds
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Term
Liquid Phases During Digestion in Small Bowel Components of the
Aqueous Phase |
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Definition
- all water soluble substances
- mixed micelles
- free fatty acids
- monoglycerides
- cholesterol
- fat soluble vitamins
- xenobiotics
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