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uses raw material to synthesize essential compounds |
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decomposes substances to provide energy cells need to function |
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Catabolism requires 2 essential ingredients? |
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Oxygen Organic molecules broken down by intracellular enzymes (ex. carbs, fats, proteins) |
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6 Functions of the Digestive Tracts |
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Ingestion Mechanical Processing Digestion Secretion Absorption Excretion |
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occurs when materials enter digestive tract via the mouth |
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chemical breakdown of food into smaller organic fragments for absorption by digestive epithelium |
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release of water, acids, enzymes, buffers and salts by epithelium of digestive tracts by glandular organs |
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movements of organic substrates, electrolytes, vitamins, and water across digestive epithelium into interstitial fluid of digestive tract |
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removal of waste products from body fluids |
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produced by serous membrane provides essential lubrication separates parietal and visceral surfaces allows sliding without friction ~7 liters produced daily |
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excess peritoneal fluid causing abdominal swelling |
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Four Layers of Digestive Tract |
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1. Mucosa 2. Submucosa 3. Muscularis externa 4. Serosa |
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inner lining of digestive tract lined by stratified squamous epithelium
includes: enteroendocrine cells lamina propria& muscularis mucosae |
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loose connective tissue (aerolar tissue) containing blood vessels sensory nerve endings lymphatic vessels smooth muscle cells scattered areas of lymphoid tissues |
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narrow band of smooth muscle and elastic fibers in lamina propria inner layer encircles lumen |
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layer of dense, irregular connective tissue large blood vessels and lymphatic vessels may contain exocrine glands*** |
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plexus of Meissner* contains: sensory neurons parasympathetic ganglionic neurons sympathetic postganglionic fibers |
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Definition
serous membrane convering muscularis externa |
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What moves digestive materials? |
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Definition
visceral smooth muscle tissue has rhythmic cycles of activity |
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contraction through entire muscular sheet |
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does not have a set pattern does not push material in any one direction |
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Definition
Carbonic anhydrase converts H20 + Co2 to H2CO3
H2CO3 dissociates to H+ and HCO3-
H+ is pumped out to the stomach lumen by H+/K+ pump
HCO3 is exchanged by Cl- which increases Cl concentration inside the parietal cell
Cl- diffuses to the stomach due to high concentration in the lumen due high concentration in parietal cells |
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secretion of mucins and enzyme lingual lipase |
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produce serous secretion enzyme salivary amylase (breaks down starches) |
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Sublingual Salivary Glands |
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Definition
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Submandibular Salivary Glands |
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Definition
secrete buffer, glycoproteins(mucins) and salivary amylase |
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Definition
Produce 1.0-1.5 liters of saliva each day
70% by submandibular glands
99.4% water
Buffers NCO3
Enzymes |
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Definition
moistening and lubricating materials in the mouth
initiating digestion of complex carbs by the enzyme salivary amylase |
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What accelerates secretion of salivary glands? |
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Definition
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Definition
3 layers
mucosa submucosa muscularis |
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Major Functions of the Stomach |
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Definition
storage of ingested food mechanical breakdown of ingested food disruption of chemical bonds in food material by acid and enzymes Production of intrinsic factor, a glycoprotein required for absorption of vitamin B12 in the small intestine |
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Preliminary Digestion in stomach by: |
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plays key role in digestion and absorption of nutrients 90% of nutrient absorption occurs in small intestine |
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3 Sections of Small Intestine |
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What type of epithelium lines the stomach? |
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Definition
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shallow depressions that open onto the gastric surface |
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secrete intrinsic factors (required for B12 absorption) and hydrochloric acid |
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Definition
most abundant near base of gastric gland
secrete pepsinogen (inactive)
HCL converts to pepsinogen to pepsin (break down proteins,conversion of pepsinogen to pepsin) |
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produce mucous secretion G cells D cells |
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somatostatin (hormone inhibits release of gastrin) |
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Where are motor neurons located? |
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Definition
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control smooth muscle contraction which causes movement of materials along digestive tract and glandular secretion |
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local reflexes small segments of digestive tract operate completely outside the CNS |
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Higher level of control of digestive and glandular activities control large peristaltic waves involve interneurons and motor neurons in CNS |
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18 peptide hormones that affect: most aspects of digestive function activities of other systems |
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Functions of the Oral Cavity |
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Definition
Sensory analysis of material before swallowing mechanical processing through actions of the teeth, tongue Lubrication: mixing with mucous and salivary gland secretion Limited digestion** of carbs and lipids** |
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Definition
nonkeratinized stratified squamous epithelium |
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Definition
produce a lot of mucus when chyme arrives from stomach |
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Definition
watery intestinal juice 1.8 liters er day that enters intestinal lumen |
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Once chyme reaches duodenum? |
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Definition
weak peristaltic contractions move it slowly toward jejunum via parasympathetic stimulation |
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If __________ hormones absent during fetal development? |
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Definition
nervous system fails to develop mental retardation occurs
if T4 concentration decline prior to puberty, normal skeletal development will not continue |
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Definition
allows passage of glucose and amino acids across plasma membranes |
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promote absorption of calcium salts for deposition in bone
inadequate levels cause weak and flexible bones |
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Definition
maintains normal blood glucose concentrations
mobilizes lipid reserves |
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feedback control for appetite
controls normal levels of GnRH |
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_________ _______ secrete inhibin |
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Definition
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androgens in interstitial cells testosterone |
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Definition
produces thymosins
help develop and maintain normal immune defenses. |
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Zone glomerulosa Zona fasiculata Zona reticularis |
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Definition
outermost layer
mineralcorticoids (aldosterone) |
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Definition
middle layer
glucoccorticoids |
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Definition
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Term
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Definition
mineralocortocoids glucoccorticoids sex hormones |
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Hormone released by adrenal medulla |
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Definition
epinephrine & norepinephrine |
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Adrenal medulla is part of: |
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Definition
sympathetic nervous system |
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Endocrine cells of pancreas |
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Definition
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Definition
stimulates osteoclasts and inhibits osteoblasts
enhances reabsorption of Ca2+ at kidneys, reducing urinary losses
Stimulates formation and secretion of calcitrol by the kidneys |
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Normal Blood Glucose Level |
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Definition
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Thyroid Hormones can bind to receptors |
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Definition
cytoplasm surfaces of mitochondria nucleus |
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Term
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Definition
helps regulate concentrations of Ca2+ in body fluids
inhibits osteoclasts, which slow the rate of Ca2+ release from bone
Stimulates Ca2+ excretion by kidneys |
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Folicullar Cells produce: |
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Definition
thyroid hormones T3 and T4 |
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Definition
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reabsorption of water
elevated blood pressure and volume |
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Posterior Pituitary to Uterus |
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Posterior Pituitary to Ductus deferns and prostate |
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Definition
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Posterior Pituitary to Kidney |
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Definition
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epinephrine and norepinephrine
glucoccortiocoids (cortisol) |
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estrogen, inhibin and progesterone |
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PTH causes and __________ in Ca2+ blood |
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Definition
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__________ __ is needed for Ca2+ regulation |
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Definition
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Definition
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produce peptide hormones identical to GH-IH |
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Definition
secrete pancreatic polypeptide (PP) |
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Definition
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Definition
accelerated glucose uptake accelerates glucose utilization and enhances ATP Stimulates glycogen formation Stimulates amino acid absorption and protein synthesis Stimulates triglyceride formation in adipose tissue |
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Term
After glucose levels fall, _______ _______ in the pancreas secrete _________ |
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Definition
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Insulin _________ blood ___________ |
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Definition
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What hormones increase blood glucose? |
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Definition
glucagon glucoccorticoids like cortisol GH catechloamines (epi and norepinephrine) |
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Definition
insulin dependent
no production of insulin by pancreatic beta cells |
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Term
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Definition
most common form insulin resistance usually associated with obesity |
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Term
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Definition
calcitriol erythropoietin enzyme renin |
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Term
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Definition
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Three phases of stress response |
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Definition
Alarm Resistance Exhaustion |
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Term
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Definition
sympathetic activation adrenal medulla activated release of epi or noepinephrine |
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Term
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Definition
glucoccorticoids (from adrenal medulla) epinephrine GH thyroid hormones |
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Definition
failure of electrolyte balance inability to produce glucoccorticoids |
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Term
Parathyroid and Calcitonin regulate calcium |
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Definition
promote absorption of calcium salts for deposition in bone
low levels can cause weak and flexible bones |
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Term
Releasing hormones from hypothalamus |
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Definition
TRH -> TSH -> increase thyroid hormones CRH -> ACTH -> increase glucoccorticoids GnRH ->LH & FSH -> ^ inhibin, progestins, androgens, estrogens |
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Definition
regulatory hormones which blood vessels carry to the anterior pituitary gland
this vessel forms a portal system |
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Definition
targets interstitial cells the secrete testosterone & other androgens |
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Definition
with testosterone present this FSH will promote spermatogenesis |
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Term
What cells produce testosterone? |
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Definition
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Effect of inhibin on gonadotrophins? |
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Definition
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What ovary cell produces progesterone? |
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Definition
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What ovary cell produces estrogen? |
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Definition
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Functions of the Large Intestine |
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Definition
reabsorption of water compaction of intestinal contents into feces absorption of imp vitamins produced by bacteria storage of fecal material prior to defecation |
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Definition
exocrine secretion of pancreas |
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Definition
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Definition
breaks down complex lipids |
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Definition
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Definition
70% of all pancreatic enzyme production** |
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Definition
break large protein complexes |
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Definition
break small peptides into amino acids |
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After ovulation ___________ levels decrease |
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Definition
estrogen levels
and progesterone increase |
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male stays the same
female different throughout cycle |
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