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Definition
The basic description of the plasma membrane (or any vivo biological membrane really) in which the membrane is said to be fluid due to the ability of the membrane to move and morph and mosaic due to it being composed of multiple types of lipids, proteins, and carbohydrates. |
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Definition
Mediate attachment of a cell to another proximal cell or the ECM |
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Definition
The process by which outside material is engulfed into the cell.
The membrane froms a capsule through engulfing the extracellular material. |
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Definition
A specific form of endocytosis
Process by which solid materials are absorbed and capsulated within the cell.
Used in the immune system to degrade foreign bodies. |
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Definition
Specialized form of endocytosis
The process is specific to small molecule endocytosis, in which the small vesicle that is formed is fused with a lysosome for to hydrolyze or break down the small particle |
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Definition
The process through which a substance is sectreted out of the cell, via fusing of a vesicle membrane with the plasma membrane. |
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Definition
Relates the diffusion of a material through a gradient
J=-DA(ΔC/Δx) |
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Definition
A pore in the membrane of the cell that is avaliable for water movement |
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Definition
Channels in the plasma membrane (regulated) for the movements of small ions through the membrane |
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Definition
Simple diffusion of water |
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Definition
The pressure that is needed to be applied to a solution to prevent osmosis |
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Definition
Sterol molecule found in the membrane |
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Definition
The factor in Fick's law that incorperates temperature, size of the molecule, viscosity of the fluid, and shape of molecule. |
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Definition
Osmotic pressure generated by disolved solute molecules in 1L of solvent |
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Definition
Refers the the osmotic pressure generated when molecules are dissolved in 1 kg of water |
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Definition
Solutions which do not change the volume of a cell |
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Definition
Solutions which increase the volume of a cell |
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Definition
Solutions which decrease the volume of the cell |
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Definition
Solutions which have the same osmolality. |
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Definition
A condition in which the total amount of solutes (both permeable and impermeable) in a solution is greater than that of another solution
(aka a greater osmolality) |
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Definition
A condition in which the total amount of solutes (both permeable and impermeable) in a solution is less than that of another solution
(aka a smaller osmolality) |
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Term
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Definition
π=RT(Φic)
At constant temperature, the osmotic pressure of dilute solutions is proportional to the concentration (number of molecules) of the dissolved substance |
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Term
Reflection Coefficient
(aka Osmotic Coefficient) |
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Definition
A coefficient to symbolize the relative permability of a plasma membrane (σ)
Found in the equation:
π=σ(nCRT)
where π is the ability of a molecule to pass thru a membrane |
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Definition
The movement of a molecule/substance against its gradient |
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Term
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Definition
The transport of a molecule/substance coupled to the hydrolysis of ATP |
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Term
Secondary Active Transport |
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Definition
The use of solute carrier(s) coupled to the transport of another molecule/solute against its gradient |
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Definition
The transport of a solute with its gradient. |
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Definition
Calculates the potential across a membrane at which the concentration gradient force is equal to the electrical force.
E=(60/z)*log(Xi/Xo) |
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Definition
A solute carrier that couples the movement of two or more molecules/ions across the membrane in the same direction |
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Definition
A solute carrier that couples the movement of two or more molecules/ions across the membrane in opposite direction |
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Definition
A situation in which state variables remain constant even under flow / exchange |
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Term
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Definition
A state in which competing influences on a system are all equal |
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Definition
A state in which a system has no charge |
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Term
Resting Membrane Potential |
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Definition
Difference in voltage across the membrane in an unstimulated state - tends to be negative via measurement of the ICF volatage against the ECF volage |
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Term
Electrochemical Equilibrium |
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Definition
A state in which the concentration and voltage forces across the membrane are equal |
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Definition
The event in which concentration gradients are forced to vary due to the presence of an semi-permiable membrane
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Definition
A molecule transporter which will generate a potential (for example the Na/K ATPase) |
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Term
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Definition
E=60*log([Ko]+α[Nao])
([Ki]+α[Nai]) |
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Definition
A conductance which decreases over distance |
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Definition
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Definition
Cell to cell signalling which takes place over a large distance - such as hormone stimulation |
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Definition
Cell to cell signalling which takes place over a small distance, stimulation of close cells. |
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Definition
Cell to self signalling via a released stimulous. |
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Definition
A rapid, all-or-none change in the membrane potential followed by a return to the resting membrane potential |
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Definition
A change in voltage difference towards nuetrality |
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Definition
A change in voltage potential further from nuetrality. |
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Definition
A return of voltage potential to its origional after a hyper- or de-polarization |
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Term
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Definition
A stimulous which is not strong enough to stimulate an Action Potential, but does change the charge of local area of a cell. |
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Term
Propogation without Decrement |
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Definition
Conservation of an Action Potential throughout a cell |
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Term
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Definition
Refered to when a stimulous produces a full-sized action potential or fails to do so. |
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Term
Hyperpolarizing After Potential
or
Afterhyperpolarization |
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Definition
A small period of over-shooting occuring after repolarization |
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Term
Absolute Refractory Period |
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Definition
Time after an Action Potential during which the cell is unresponsive to stimulous. |
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Term
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Definition
When a nerve depolarizes slowly, the normal threshold is passed without an Action Potential |
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Term
Stimulation of Calcium release in the ER
(the pathway) |
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Definition
Ligand with α1 subunit (G Protein)
↓
Phospholipase C (PLC)
↓ (converts:)
Phosphatidynlinositol bisphosphate (PIP2) (Converts it to:)
↓
Inositol 1,4,5-triphosphate (InsP3)
+
Diacyl glycerol (DAG)
InsP3 diffuses to the ER where it stimulates the release of Ca into cytosol
DAG activates Protein kinase C (PKC) which phosphorylates effector proteins |
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Term
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Definition
The transmission of a signal between two cells.
In the nervous system it is the process through which electrical signals are transfered down the nerves. |
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Definition
A low-resistance pathway between cells that allows current to flow directly from one cell to another, this also allows for the sharing of small molecules between the cells. |
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Term
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Definition
A specialized junction that allows for intracellular signalling molecules (less than 1200 Da) to diffuse from one cytoplasm to another |
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Definition
A family of structurally related transmembrane proteins that form gap junction in vertebrates |
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Term
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Definition
Unlike electrical synapse there is no gap junction to stimulate the receieving cell. Instead there is a separation that allows for chemcial stimulous to diffuse from one cell to the receptors of the recieving cell. |
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Term
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Definition
The chemical intermediates that diffuse thru the synaptic cleft in a chemical synapse |
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Term
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Definition
The space between two cells thru which neurstimulators travel. |
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Term
Excitatory Postsynaptic Potential (EPSP) |
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Definition
A change in the membrane potential of a post-synaptic cell which increases the cells excitability (its probability of firing action potentials) |
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Term
Inhibatory Postsynaptic Potential (IPSP) |
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Definition
A change in the membrane potential of a post-synaptic cell which decreases the cells excitability (its probability of firing action potentials) |
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Term
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Definition
One nueron that uses multiple neurostimulators to connect to several different neurons |
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Term
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Definition
The time (typically 0.3-0.5 ms) required for a neurotransmitter to be released from a presynaptic membrane, diffuse across the synaptic cleft. |
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Term
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Definition
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Term
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Definition
Store various neurotransmitters that are released at the synapse. |
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Term
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Definition
Within the PNS it is the transmitter at a neuromuscular junction, sympathetic and parasympathetic ganglia, and all fibers from the parasympathetic ganglia. |
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Term
End Plate Potential (EPP) |
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Definition
Are the depolarizations of skeletal muscle fibers caused by neurotransmitter binding to the postsynaptic membrane in the neuromuscular junctions. |
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Term
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Definition
Anatomical area of a neuron where the soma attaches to the axon. |
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Term
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Definition
The ability of a soma to recieve stimulous/inhibatory signals from multiple cells and be able to summate them all. |
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Term
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Definition
The signalling of a cell, which acheives its action potential, via a single cell |
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Term
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Definition
This is the decrease of release of transmitter as supplies are fatigued |
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Term
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Definition
An enzyme that degrades ACH to choline and acetate (-) ion. These can no longer bind to the receptor and are released. About half of these hydrolysis products are taken up by the presynaptic cell and recycled into ACH.
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Term
Miniture End Plate Potentials |
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Definition
MEPPs are small (0.4 mV) depolarizations that appear even when the pre-synaptic neuron is inactive. They appear at regular intervals and are all of nearly the same size. They can be blocked by curare. They have been shown to be the result of spontaneous release of ACH
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Term
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Definition
Three neurons are involved, the pre and post synaptic neurons and an inhibitory neuron that ends near the terminus of the pre-synaptic neuron.
1. The presynaptic neuron has receptors for the inhibitory neuron
transmitter
2. The inhibitory neuron depolarizes the pre-synaptic neuron, this causes it to release less transmitter each time it transmits an AP.
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Term
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Definition
It is the long-lasting improvement in communication between two neurons that results from stimulating them simultaneously |
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Term
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Definition
Weakening of a neuronal synapse that lasts from hours to days. It results from either strong synaptic stimulation or persistent weak synaptic stimulation |
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Term
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Definition
The "flight-or-fight" hormones that are released by the adrenal glands |
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Term
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Definition
A monoamine neurotransmitter which stimulates the movements of the gut |
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Term
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Definition
Glycine is an inhibitory neurotransmitter in the CNS. When glycine receptors are activated, chloride enters the neuron via ionotropic receptors, causing an (IPSP) |
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Term
Gamma-aminobutyric Acid
(GABA) |
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Definition
GABA acts at inhibitory synapses in the CNS by binding to specific transmembrane receptors of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either Cl- into the cell or K+ out of the cell. This action results in a negative change in the membrane potential, usually causing hyperpolarization. |
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Term
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Definition
Glutamate is the most abundant excitatory neurostimulator. |
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Term
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Definition
Excitatory neurotransmitter that stimulates NMDA receptors (not as stong of a stimulator as glutamate) |
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Term
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Definition
A gaseous neurotransmitter that diffuses across the synaptic cleft. |
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Term
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Definition
Can be co-released with another neurotransmitter and act as synergistically or antagonistically.
Can function as a neurotransmitter on its own. |
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Term
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Definition
A peptide that is probablt the transmitter used at synapses mady by primary sensory neurons.
A primary neurotransmitter |
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Term
Nicotinic Cholinergic Receptor |
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Definition
Acetylcholine receptors which bind nicotine for stimulation. |
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Term
Muscarinic Cholinergic Receptor |
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Definition
Acetylcholine receptors which bind muscarine for stimulation. |
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Term
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Definition
A glutamate receptor susceptable to the antagoinis AMPA |
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Term
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Definition
A glutamate receptor susceptable to the antagoinis NMDA |
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Term
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Definition
An agonist is a drug that binds to a receptor of a cell and triggers a response (action) by the cell. An agonist often mimics the action of a naturally occurring substance. |
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Term
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Definition
Typically a transmembrane protein that when bound to a signalling ECF molecule, will stimulate an ICF response |
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Term
Signal Transduction Pathway |
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Definition
The process through which a signalling molecule will trigger and intracellular response |
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Term
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Definition
A chemical signalling molecule that releases from one area of the body to another. |
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Term
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Definition
Proteins that transfer a phosphate to another molecule from a high energy molecule (typically ATP) |
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Term
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Definition
Proteins that removes a phosphate to another molecule to form a free phosphate ion. |
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