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Physiology - Basic Cell
Cell Membranes, Cell Transport, Equilibrium, Action Potentials, Signal Transduction, and Synaptic Transmission
97
Physiology
Graduate
09/09/2009

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Term
Fluid Mosaic Model
Definition
The basic description of the plasma membrane (or any vivo biological membrane really) in which the membrane is said to be fluid due to the ability of the membrane to move and morph and mosaic due to it being composed of multiple types of lipids, proteins, and carbohydrates.
Term
Integrins
Definition
Mediate attachment of a cell to another proximal cell or the ECM
Term
Endocytosis
Definition

The process by which outside material is engulfed into the cell.

 

The membrane froms a capsule through engulfing the extracellular material.

Term
Phagocytosis
Definition

A specific form of endocytosis

 

Process by which solid materials are absorbed and capsulated within the cell.

 

Used in the immune system to degrade foreign bodies.

Term
Pinocytosis
Definition

Specialized form of endocytosis

 

The process is specific to small molecule endocytosis, in which the small vesicle that is formed is fused with a lysosome for to hydrolyze or break down the small particle

Term
Exocytosis
Definition
The process through which a substance is sectreted out of the cell, via fusing of a vesicle membrane with the plasma membrane.
Term
Fick's Law
Definition

Relates the diffusion of a material through a gradient

 

J=-DA(ΔC/Δx)

Term
Aquaporins
Definition
A pore in the membrane of the cell that is avaliable for water movement
Term
Ion Channels
Definition
Channels in the plasma membrane (regulated) for the movements of small ions through the membrane
Term
Osmosis
Definition
Simple diffusion of water
Term
Osmotic Pressure
Definition
The pressure that is needed to be applied to a solution to prevent osmosis
Term
Cholesterol
Definition
Sterol molecule found in the membrane
Term
Diffusion Coefficient
Definition
The factor in Fick's law that incorperates temperature, size of the molecule, viscosity of the fluid, and shape of molecule.
Term
Osmolarity
Definition
Osmotic pressure generated by disolved solute molecules in 1L of solvent
Term
Osmolality
Definition
Refers the the osmotic pressure generated when molecules are dissolved in 1 kg of water
Term
Isotonic
Definition
Solutions which do not change the volume of a cell
Term
Hypotonic
Definition
Solutions which increase the volume of a cell
Term
Hypertonic
Definition
Solutions which decrease the volume of the cell
Term
Isoosmotic
Definition
Solutions which have the same osmolality.
Term
Hyperosmotic
Definition

A condition in which the total amount of solutes (both permeable and impermeable) in a solution is greater than that of another solution

(aka a greater osmolality)

Term
Hypoosmotic
Definition

A condition in which the total amount of solutes (both permeable and impermeable) in a solution is less than that of another solution

(aka a smaller osmolality)

Term
van't Hoff's Law
Definition

π=RT(Φic)

 

At constant temperature, the osmotic pressure of dilute solutions is proportional to the concentration (number of molecules) of the dissolved substance

Term

Reflection Coefficient

 

(aka Osmotic Coefficient)

Definition

A coefficient to symbolize the relative permability of a plasma membrane (σ)

 

Found in the equation:

π=σ(nCRT)

where π is the ability of a molecule to pass thru a membrane

Term
Active Transport
Definition
The movement of a molecule/substance against its gradient
Term
Primary Active Transport
Definition
The transport of a molecule/substance coupled to the hydrolysis of ATP
Term
Secondary Active Transport
Definition
The use of solute carrier(s) coupled to the transport of another molecule/solute against its gradient
Term
Passive Transport
Definition
The transport of a solute with its gradient.
Term
Nernst Equation
Definition

Calculates the potential across a membrane at which the concentration gradient force is equal to the electrical force.

 

E=(60/z)*log(Xi/Xo)

Term
Symporter
Definition
A solute carrier that couples the movement of two or more molecules/ions across the membrane in the same direction
Term
Antiporter
Definition
A solute carrier that couples the movement of two or more molecules/ions across the membrane in opposite direction
Term
Steady State
Definition
A situation in which state variables remain constant even under flow / exchange
Term
Equilibrium
Definition
A state in which competing influences on a system are all equal
Term
Electroneutrality
Definition
A state in which a system has no charge
Term
Resting Membrane Potential
Definition
Difference in voltage across the membrane in an unstimulated state - tends to be negative via measurement of the ICF volatage against the ECF volage
Term
Electrochemical Equilibrium
Definition
A state in which the concentration and voltage forces across the membrane are equal
Term
Gibbs-Donnan Equilibrium
Definition

The event in which concentration gradients are forced to vary due to the presence of an semi-permiable membrane

 

Term
Electrogenic Pump
Definition
A molecule transporter which will generate a potential (for example the Na/K ATPase)
Term
Goldman Equation
Definition

E=60*log([Ko]+α[Nao])

                ([Ki]+α[Nai])

Term
Decremental Conduction
Definition
A conductance which decreases over distance
Term
Length Constant
Definition
λ=(rm/rin)1/2
Term
Endocrine Signalling
Definition
Cell to cell signalling which takes place over a large distance - such as hormone stimulation
Term
Paracrine Signalling
Definition
Cell to cell signalling which takes place over a small distance, stimulation of close cells.
Term
Autocrine Signalling
Definition
Cell to self signalling via a released stimulous.
Term
Action Potential
Definition
A rapid, all-or-none change in the membrane potential followed by a return to the resting membrane potential
Term
Depolarization
Definition
A change in voltage difference towards nuetrality
Term
Hyperpolarization
Definition
A change in voltage potential further from nuetrality.
Term
Repolarization
Definition
A return of voltage potential to its origional after a hyper- or de-polarization
Term
Local response
Definition
A stimulous which is not strong enough to stimulate an Action Potential, but does change the charge of local area of a cell.
Term
Propogation without Decrement
Definition
Conservation of an Action Potential throughout a cell
Term
"All-or-None" Response
Definition
Refered to when a stimulous produces a full-sized action potential or fails to do so.
Term

Hyperpolarizing After Potential

or

Afterhyperpolarization

Definition
A small period of over-shooting occuring after repolarization
Term
Absolute Refractory Period
Definition
Time after an Action Potential during which the cell is unresponsive to stimulous.
Term
Accomodation
Definition
When a nerve depolarizes slowly, the normal threshold is passed without an Action Potential
Term

Stimulation of Calcium release in the ER

 

(the pathway)

Definition

Ligand with α1 subunit (G Protein)

Phospholipase C (PLC)

↓ (converts:)

Phosphatidynlinositol bisphosphate (PIP2)  (Converts it to:)

Inositol 1,4,5-triphosphate (InsP3) 

+

Diacyl glycerol (DAG)

 

InsP3 diffuses to the ER where it stimulates the release of Ca into cytosol

 

DAG activates Protein kinase C (PKC) which phosphorylates effector proteins

Term
Synapse
Definition

The transmission of a signal between two cells. 

 

In the nervous system it is the process through which electrical signals are transfered down the nerves.

Term
Electrical Synapse
Definition
A low-resistance pathway between cells that allows current to flow directly from one cell to another, this also allows for the sharing of small molecules between the cells.
Term
Gap Junction
Definition
A specialized junction that allows for intracellular signalling molecules (less than 1200 Da) to diffuse from one cytoplasm to another
Term
Connexins
Definition
A family of structurally related transmembrane proteins that form gap junction in vertebrates
Term
Chemical Synapse
Definition
Unlike electrical synapse there is no gap junction to stimulate the receieving cell.  Instead there is a separation that allows for chemcial stimulous to diffuse from one cell to the receptors of the recieving cell.
Term
Neurotransmitters
Definition
The chemical intermediates that diffuse thru the synaptic cleft in a chemical synapse
Term
Synaptic Cleft
Definition
The space between two cells thru which neurstimulators travel.
Term
Excitatory Postsynaptic Potential (EPSP)
Definition
A change in the membrane potential of a post-synaptic cell which increases the cells excitability (its probability of firing action potentials)
Term
Inhibatory Postsynaptic Potential (IPSP)
Definition
A change in the membrane potential of a post-synaptic cell which decreases the cells excitability (its probability of firing action potentials)
Term
Neuromodulator
Definition
One nueron that uses multiple neurostimulators to connect to several different neurons
Term
Synaptic Delay
Definition
The time (typically 0.3-0.5 ms) required for a neurotransmitter to be released from a presynaptic membrane, diffuse across the synaptic cleft.
Term
Soma
Definition
Nerve cell body
Term
Synaptic vesicles
Definition
Store various neurotransmitters that are released at the synapse.
Term
Acetylcholine (Ach)
Definition
Within the PNS it is the transmitter at a neuromuscular junction, sympathetic and parasympathetic ganglia, and all fibers from the parasympathetic ganglia.
Term
End Plate Potential (EPP)
Definition
Are the depolarizations of skeletal muscle fibers caused by neurotransmitter binding to the postsynaptic membrane in the neuromuscular junctions.
Term
Axon Hillock
Definition
Anatomical area of a neuron where the soma attaches to the axon.
Term
Spatial Summation
Definition
The ability of a soma to recieve stimulous/inhibatory signals from multiple cells and be able to summate them all.
Term
Temporal Summation
Definition
The signalling of a cell, which acheives its action potential, via a single cell
Term
Synaptic Fatigue
Definition
This is the decrease of release of transmitter as supplies are fatigued
Term
Acetylcholinesterase
Definition

An enzyme that degrades ACH to choline and acetate (-) ion. These can no longer bind to the receptor and are released. About half of these hydrolysis products are taken up by the presynaptic cell and recycled into ACH.

Term
Miniture End Plate Potentials
Definition

MEPPs are small (0.4 mV) depolarizations that appear even when the pre-synaptic neuron is inactive. They appear at regular intervals and are all of nearly the same size. They can be blocked by curare. They have been shown to be the result of spontaneous release of ACH

Term
Presynaptic Inhibition
Definition

Three neurons are involved, the pre and post synaptic neurons and an inhibitory neuron that ends near the terminus of the pre-synaptic neuron.

 

1. The presynaptic neuron has receptors for the inhibitory neuron

transmitter

 

2. The inhibitory neuron depolarizes the pre-synaptic neuron, this causes it to release less transmitter each time it transmits an AP.

Term
Long Term Potentiation
Definition
It is the long-lasting improvement in communication between two neurons that results from stimulating them simultaneously
Term
Long Term Depression
Definition
Weakening of a neuronal synapse that lasts from hours to days. It results from either strong synaptic stimulation  or persistent weak synaptic stimulation
Term
Catecholamines
Definition
The "flight-or-fight" hormones that are released by the adrenal glands
Term
Serotonin
Definition
A monoamine neurotransmitter which stimulates the movements of the gut
Term
Glycine
Definition
Glycine is an inhibitory neurotransmitter in the CNS. When glycine receptors are activated, chloride enters the neuron via ionotropic receptors, causing an (IPSP)
Term

Gamma-aminobutyric Acid

(GABA)

Definition
GABA acts at inhibitory synapses in the CNS by binding to specific transmembrane receptors of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either Cl- into the cell or K+ out of the cell. This action results in a negative change in the membrane potential, usually causing hyperpolarization.
Term
Glutamate
Definition
Glutamate is the most abundant excitatory neurostimulator.
Term
Aspartate
Definition
Excitatory neurotransmitter that stimulates NMDA receptors (not as stong of a stimulator as glutamate)
Term

Nitric Oxide

(NO)

Definition
A gaseous neurotransmitter that diffuses across the synaptic cleft.
Term
Neuropeptides
Definition

Can be co-released with another neurotransmitter and act as synergistically or antagonistically.

 

Can function as a neurotransmitter on its own.

Term
Substance P
Definition

A peptide that is probablt the transmitter used at synapses mady by primary sensory neurons.

 

A primary neurotransmitter

Term
Nicotinic Cholinergic Receptor
Definition
Acetylcholine receptors which bind nicotine for stimulation.
Term
Muscarinic Cholinergic Receptor
Definition
Acetylcholine receptors which bind muscarine for stimulation.
Term
AMPA Receptor
Definition
A glutamate receptor susceptable to the antagoinis AMPA
Term
NMDA Receptors
Definition
A glutamate receptor susceptable to the antagoinis NMDA
Term
Agonists
Definition
An agonist is a drug that binds to a receptor of a cell and triggers a response (action) by the cell. An agonist often mimics the action of a naturally occurring substance.
Term
Receptor Proteins
Definition
Typically a transmembrane protein that when bound to a signalling ECF molecule, will stimulate an ICF response
Term
Signal Transduction Pathway
Definition
The process through which a signalling molecule will trigger and intracellular response
Term
Hormone
Definition
A chemical signalling molecule that releases from one area of the body to another.
Term
Protein Kinases
Definition
Proteins that transfer a phosphate to another molecule from a high energy molecule (typically ATP)
Term
Protein Phosphatases
Definition
Proteins that removes a phosphate to another molecule to form a free phosphate ion.
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