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M2 muscarinic cholinergic (M4) |
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M3 muscarinic cholinergic (M1,M5) |
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act adenylate cyclase, open cell membrane Ca++ channels |
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Inhibit adenylate cyclase, open cell membrane K+ channels |
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Activate phospholipase C-beta |
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ACh Muscarine (agonist) Atropine (antagonist) |
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Nicotinic Sub-type N muscle |
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ACh Nicotine (agonist) Curare (antagonist) |
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Prostitutes dying wish was to take her boobies to a leuau to stop guys w/no balls from making rounds, to let her gonads go!
Irrev prostate cancer, gynecomastia, Leuprolide, anti-androgen, bilateral orchiectomy and LHRH analog, stop circulating, and release of GNRH. |
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Flutes buy guys time when making rounds.
Anti-andro, decrease circulating to buy time. |
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A nasty smell.
Aromatase inhib. |
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Exams smell bad to women wearing full vests.
Aromatase inhib, est receptor block b/c have no estradiol to bind to receptors. (Fulvest is also anti-est) |
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Hammocks are bad for post-menopausal competitive depressed women.
Anti-est, compete for est receptor, drives Liver metabolism (CYP2D6) to active, bad for x-depression drugs (Paxl, prazac) b/c they need the enzymes too. |
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Loose temper, loose hair and yell "FU!!!"
Less TMP via inhib thymidylate synthetase. Hair loss like cyclophos. |
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Flute players on extreme steroids lay in hammocks @ leuau wearing nasty vests.
Flutamide, Exemestane, Corticoids, Tamoxifen, Leuprolide, Anastrozole, Fulvestrant. |
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Bloody alky peed on a solid plate S/F chocolate chip cookies.
IV in, like alkylating agents, renal tox, solid tumors, platinum containing, manitol diuresis and hydration, like chocolate chip cookie discovery (from lab to XB). |
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Foley catheters rescue patients.
In periph, give Folinic acid and can make tetra w/out dyhydro enzyme. |
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Bald Adrian stalks Deena, latches on and stops her from running, gives her a heart attack, and makes her keep a low profile. Too bad because its common to see her running as shes a solid runner.
Hair loss, Adriamycin, binds DNA to stop RNA, cardio tox, keeps blood levesl below a certain amount. Common chemo, solid tumors. |
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Meet my solid Alky.
Alkylating, solid tumors. |
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Adrian blew my acting gig, sad cuz I'm such a mighty natural.
Adriamycin (doxorubicin), Bleomycin, Actinomycin D, Mitomycin, Natural Ab's. |
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Blowing solidly wont break Deena.
Pulmonary fibrosis, solid tumors, DNA breaks. |
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Runners naturally act like don't have stress fractures, and can run when very sick.
RNA synth, non-cycle active, BM supp, Very toxic, immuno sup (lots). |
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Kids on meth sniff watery glue.
DON'T GIVE TO RENAL ISSUES!!!! sniff to bring into cell, inhib dihydrofolate reductase (can't become tetra), conj to Glu to trap inside cells. |
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I met Vin, he blasted my solid cycle and moved on to cute brainy Christine because shes a natural.
Metaphase stop, Vins's, Blast: myelosupp, solid tumors, cycle active, cristine: CNS, acute leuk. Natual Product |
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Solid tax on all natural bike tubes.
Solid tumor, taxol, natural product, cycle active microtubles less pliable so can't pull apart. |
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Denas wedding ring altered her temporary (non-active) status.
DNA synth, GEM, alteres temp activity, non-cycle active, solid tumor. |
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Keep yelling FU! at pros who use tees or stay in water!!
Keeps 5-FU high b/c competes for dyhydropyrimidine dehydrogenase. Prodrug metabolized to flurouracil.
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Captain has pure IMPotence.
Blocks IMP form, and other steps to purine synthesis.
Thioguanine does same for GMP. (alter structure and function) w/both = complementary inhib.
6-mer blocks IMP and it's change to AMP and GMP = sequential inhib. |
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Booze for my alkys.
Myelosupp, alkylating agent. |
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Pho long horn rams @ BU are fat, ride bus, b/c got BUI for being non-functional.
Cyclophosp (hair loss, rapid, metabolic activation and normal liver), Chlorambucil (least toxic, for chronic), BCNU (IV, Lipid, CNS), Busulfate (myelosup), non-cycle active, modify pre-formed (change structure and function), alkylating agents. |
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