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PHYSCI5
DIET AND EXERCISE MIDTERM
78
Science
Undergraduate 1
10/20/2009

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Cards

Term
LEADING CAUSES OF DEATH IN THE UNITED STATES
Definition

#1: cardiovascular disease-heart attack and stroke

#2: cancer

#5: diabetes

cvd and cancer account for 2/3 of all deaths in US

Term
second leading cause of death in US
Definition
cancer
Term
DEATH IN THE US...
Definition
at least 300,000 deaths annually: physical inactivity and poor dieting
Term
LAST 25-30 YEARS...
Definition
death from cardiovascular disease has decreased/cancer has increased
Term
CV disease surgery...
Definition
is ineffective if individual does not change lifestyle
Term
1900s:
Definition

death from heart disease:8%

cancer:4%

main causes were:infectious disease.flu.tuberculosis.pneumonia.

Term
Reasons for differences in causes of death:
Definition

1.improved sanitation[purified water systems][sewers]

2.improvement in medicine

3.natural elimination of diseases

4.lifestyle[cancer/heart disease take long to develop]

Term

EPA

(Environmental Protection Agency)

Definition
approve and regulate chemicals to protect environment and living organisms./they sometimes overlook certain chemicals that are used and harmful to humans.
Term
Life exptectancy
Definition
an estimate of how long one will live on average 
Term
Lifespan
Definition
how long the population can survive; has not changed drastically since 1900.
Term
Physiological Age can be reduced by...
Definition
sleep.food intake.exercise.not smoking.moderate alcohol consumption.controlling stress.
Term
3 major macronutrients...
Definition

FAT...9cal/gram

WHOLE GRAINS...4cal/gram

PROTEINS...4cal/gram

Term
Typical American diets, in comparison with a high-fiber, low-fat, moderate protein diet...
Definition
contains more FAT!
Term
Most chronic diseases are caused by...
Definition
lifestyle!
Term
Hormones
Definition
signaling molecules that help the body communicate
Term
Body cells communicate with eacother by...
Definition
via hormones, action potential
Term
Action potential
Definition
is a nerve impulse that changes the permeability of the cell membrane
Term
Levels of structural organization
Definition

1.Chemical-Atomic and Molecular

Atoms: basic building blocks

2. CELLULAR

cell:basic unit of living organisms

3. TISSUE

cells form tissues

4. ORGAN

-made up of 2 or more tissues

-ex. the heart[muscle, connective tissue, blood vessel tissue]

5.SYSTEM

-organs

-cardiovascular (blood, heart, vessels)

-skeletal

6.Organism

-whole individual or animal

Term
Hyperplasia
Definition
increase in cell number
Term
Hypertrophy
Definition
increase in cell size
Term
Homeostasis
Definition
a dynamic balance where the body adjusts to its environment
Term
hyperglycemia
Definition
too much gluclose
Term
hypoglycemia
Definition
too little glucose
Term
PROTEINS...
Definition

are manufactured by translation[mRNA transcript is used to construct a protein]-occurs at the ribosome

 

Term
FUNCTIONS OF PROTEINS...
Definition
enzymes..cytoskeleton..hormones...antibodies...receptors..channels..transporters...pumps
Term
Glucose Homeostasis...
Definition
regulated  by the release of insulin and glucagon; liver releases glucose, therby increasing blood glucose.
Term
Maintenence of Homeostasis...
Definition
critical for normal health b/c it regulates nervous, cardiovascular, and endocrine systems; allows bodys systems to communicate
Term
hyperglycemia is associated with...
Definition

diabetes! :(

Term
Glucose is important ...
Definition
for proper brain function, derived from carbohydrates
Term
cancer
Definition

a complex disease characterized by abnormal cell division which results in tumor formation

-growth genes-tumors form from uncontrolled division of cells

Term
tumor types: BENIGN
Definition
non-cancerous and slow growing/can be surgically removed
Term
Tumor Types: Malignant
Definition
-cancerous-cells multiply rapidly/kill cells/spread to body tissues
Term
excercise can reduce cancer...
Definition
reducing fat...fat stimulates cancer growth/colon..breast cancer associated with low levels of physical activity
Term
Hormones can affect cancer growth....
Definition
bc it is a carcinogen and can damage DNA.
Term
carcinogens
Definition

chemicals that increase the frequency of mutations and cause cancer; smoking.hormones.

they cause cancer by producing reactive free radicals, molecules with unpaired electrons that can damage DNA. ANTIOXIDANTS can block this effect.

Term
BREAST CANCER..
Definition
linked to estrogen...dietary changes...
Term
FACTORS THAT CONTRIBUTE TO BREAST CANCER...
Definition

-diet..

-lifestyle

-obesity

-estrogen

-dietary fibers

-age.older.post menstrual

Term
HORMONE REPLACEMENT IS NOT RECCOMMENDED FOR MOST WOMEN...
Definition
because it can sometimes increase the likelehood of getting cancer
Term
DETECTING CANCER EARLY...breast cancer
Definition
self-exams.physican exams.mammograms(start age 35-40)
Term

prostate cancer

RISK FACTORS

Definition

-older men 60+

-obesity and a high-fat diet

-ethnicity

-if detected early can be removed

Term
DIET AND EXERCISE FOR PROSTATE CANCER...
Definition
men on a low fat diet and regular exercise see no change in testorsterone but 50%decrease in estrogen...!!(hormone linked disease)
Term
Early detection of prostate cancer...
Definition

rectal exam at age 40.

PSA TEST. age 50.

biopsy to see if there is maglinancy.

 

Term
p53
Definition
the protein that decrease prostate cancer growth
Term
COLON CANCER/SKIN CANCER
Definition
more common in the US and Canada bc we consume more fat in our diets than other countries do
Term
A diet high in fat increases the risk of colon cancer...
Definition
b/c a high fat diet increases the amount of anerobic bacteria in the intestines affects the colon/rectal cancer/ produces more bile. bile is a promoter of tumor growth.
Term
REDUCE THE RISK OF CANCER...
Definition

1.avoid tabacco products

2.avoid prolonged exposure to sun

3.eat a low fat diet

4. consume a diet high in fruits and vegetables (antioxidants and fibers)

5.avoid environmental areas that are high in toxic chemicals and pollutants

6.participate in regular exercise

7.avoid excessive alcohol consumption

Term
Bile acids
Definition
are produced in the liver, stored in the gall bladder,and used to help break down dietary fat in the intestine
Term
Osteoperosis
Definition

caused by a lack of estrogen[more calcium, undereating,not enough cal intake]

-dietary calcium

-lack of regular exercise

-excessive protein intake[postmenoposual women]

-excessive alcohol intake

-diabetes

-medications

-lack of vitamin D

Term
Osteoperosis
Definition
excessive loss of calcium from the bones/exercise helps strengthen bones and can prevent osteoperosis
Term
bones regulated by..
Definition

osteoblasts: when blood calcium level is high

osteoclasts:when blood calcium level is low

Term
ARTHRITIS
Definition

osteoarthritis: degeneration of the articular cartilage

Gouty Arthritis:

Result of Uric acid crystals deposited in cartliage of joints/dna breakdown/genetic link

Rheumatoid Arthritis:

genetically inherited/auto-immune/bodys own immune system attacks joint tissue and causes inflammation

Term
CARDIOVASCULAR DISEASE
Definition

about 40% of deaths in the US are due to cardiovascular disease

 

Term
ischemic
Definition
heart stops receiving oxygen, heart cells die resulting in heart attack
Term
atherosclerosis
Definition
condition in which fatty material collects along walls of arteries, fatty material hardens and may eventually block the arteries
Term
Major Risk Factors For Coronary Artery Disease
Definition

-diabetes-heavy alcohol use-high blood pressure-high blood cholesterol levels-high fat diet-increasing age-obesity-personal or family history of heart disease-smoking

 

Term

LDL

low density lipoprotein

Definition

gets into the artery wall[artherosclerosis]

-"bad"cholesterol

Term

HDL

High density Lipoprotein

Definition

"good cholesterol"

picks up excess cholesterol and takes it to the liver where it can be excreted from the body.

Term
Heart recieves blood supply
Definition
from coronary arteries
Term
cholesterol
Definition
is homeostatically regulated in the bloodstream
Term
Risk Factors for Artherosclerosis
Definition
plasma cholesterol level, hypertension, diabetes, physical inactivity, insulin resistance, cigarette smoking, hypertriglyceridemia, inflammation
Term
High Fiber, Low Fat diet...
Definition
ones plasma cholesterol level appears to have a stabilizing effect.
Term

NCEP

[National Cholesterol Education Program]

Definition
created to educate individuals on the importance of cholesterol in the diet, and doctors provide guideline for lowering cholesterol
Term
NCEP's guidelines...
Definition

step 1:<30% cal from fat

<10%cal from sat fat

<300mg cholesterol

 

step2: <30%cal from fat

<70%cal from sat fat

<200mg cholesterol

*does not provide maximum benefit bc the only way to properly achieve this diet would be to starve yourself.

Term
diets high in fiber
Definition
help reduce cholesterol levels
Term
NCEP diet results in...
Definition
reduction in cholesterol levels & progression of plaque
Term
Hypertension
Definition

elevated blood pressure...

bp >140/90

pre hypertension:

bp>120/80

-due to lifestyle not aging process

-lack of exercise and poor diet

cause is unknown

-secondary.cause kown:10%people have secondary

Term
Nitric Oxide
Definition
produced in endothelial cells/cause arterioles to relax/N O allows for vasolidation of the arteries (muscle relaxation)
Term
Exercise lowers blood pressure...
Definition
bc insulin sensitivity is enhanced, increase N O, and decreases sympathetic nervous system activity
Term
Endothelial disfunction
Definition
causes a decrease in the amount of nitric oxide available
Term
vasodilation
Definition
when the arteries increase in diameter, and there is a decrease in blood pressure
Term
Diabetes
Definition

*fasting blood glucose >12 mg/dL

*non-fasting blood glucose

> 200mg/dL

*affects 24mill ppl 8% in the US

Term
type I diabetes
Definition

10% of diabetics

-teenage years

-lack of insulin secretion

-auto immune disease that leads to destruction of pancreatic beta cells that produce insulin

Term
Type II diabetes
Definition

*non-insulin dependent

*90%of diabetics

adults..now seen in children

-insulin target tissues(muscle and liver)..are resistant to the hormone

...many take insulin

-obesity sometimes

Term
insulin
Definition

hormone that causes cells to absorb glucose from the blood stream

-increases glucose transport out of th blood and into the muscle

-helps store glycogen in the muscle

Term
Glucagon
Definition
causes release of glucose from liver to bloodstream
Term
resistant to insulin
Definition
typeII diabetes..genetic factors...insulin does not fnction optimally and hyperinsulinemia results....pancreas cannot produce enough insulin; injections needed
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