Term
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Definition
binds cyclophilins --> inhibits calcineurin --> inhibit prod of IL-2 and IL-2R
predispose to viruses/lymphoma, nephrotoxic (mannitol!!), gout |
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Term
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Definition
bind FK-binding protein --> inhibits calcineurin --> inhibit prod of IL-2
nephrotoxicity, peripheral neuropathy, HTN, pleural effusion, hyperglycemia |
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Term
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Definition
= rapamycin
inhibits mTOR --> inhibits RESPONSE to IL-2
hyperlipidemia, thrombocytopenia |
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Term
|
Definition
= sirlimus
inhibits mTOR --> inhibits RESPONSE to IL-2
hyperlipidemia, thrombocytopenia |
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Term
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Definition
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Term
|
Definition
|
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Term
|
Definition
binds CD3
cytokine release syndrome, hypersensitivity reaction |
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Term
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Definition
| inhibits IMP dehydrogenase in B/T cells --> decrease dGMP (purine synthesis) --> decreased B/T cell prolife |
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Term
|
Definition
? inhibit macrophages
for RA!! |
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Term
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Definition
? decrease TNF-alpha prod
for erythema nodosum leprae, MM |
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