Term
|
Definition
| LMWH -- acts more on Xa (than thrombin) |
|
|
Term
|
Definition
| direct thrombin inhibitors |
|
|
Term
|
Definition
| direct thrombin inhibitors |
|
|
Term
|
Definition
| direct thrombin inhibitors |
|
|
Term
|
Definition
| direct thrombin inhibitors |
|
|
Term
|
Definition
| direct thrombin inhibitors |
|
|
Term
|
Definition
| direct thrombin inhibitors |
|
|
Term
|
Definition
| inhibits epoxide reductase --> no activation of vit K --> no gamma-carboxylation of glutamate residues of Vit K-dep factors |
|
|
Term
|
Definition
| brodifacoum -- like coumadin!!! |
|
|
Term
|
Definition
| LMWH -- acts more on Xa (than thrombin) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| recombinant tPA, thrombolytic |
|
|
Term
|
Definition
|
|
Term
|
Definition
| irreversibly blocking ADP receptors on platelets |
|
|
Term
|
Definition
irreversibly blocking ADP receptors on platelets
neutropenia!! |
|
|
Term
|
Definition
| phosphodiesterase III inhibitor --> increased cAMP --> inhibit platelet aggregative, vasodilates |
|
|
Term
|
Definition
| phosphodiesterase III inhibitor --> increased cAMP --> inhibit platelet aggregative, vasodilates |
|
|
Term
|
Definition
| antibody binding to glycoprotein receptor IIb/IIIa |
|
|
Term
|
Definition
folic acid analog -- inhibits dihydrofolate reductase
myelosuppression (leucovorin = folinic acid), fatty liver, mucositis |
|
|
Term
|
Definition
pyrimidine analog -- inhibits thymidylate synthtase
rescue with thymidine |
|
|
Term
|
Definition
purine (thiol) analog -- inhibits de novo purine synthesis
activated by HGPRTase
metabolized by XO |
|
|
Term
|
Definition
| purine (thiol) analog -- inhibits de novo purine synthesis |
|
|
Term
|
Definition
| pyrimidine analog -- inhibits DNA polymerase |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
1. free radicals
2. intercalating agent
3. disrupts fluid and ion transport
cardiotoxicity (dexrazoxane) |
|
|
Term
|
Definition
1. free radicals
2. intercalating agent
3. disrupts fluid and ion transport
cardiotoxicity (dexrazoxane) |
|
|
Term
|
Definition
1. free radicals
2. intercalating agent
3. disrupts fluid and ion transport
cardiotoxicity (dexrazoxane) |
|
|
Term
|
Definition
free radicals
arrest in G2!!!
pulm fibrosis
minimal myelosuppression!! |
|
|
Term
|
Definition
| inhibits topoisomerase II!! |
|
|
Term
|
Definition
| inhibits topoisomerase II!! |
|
|
Term
|
Definition
alkylating agent
activated by liver P450
hemorrhagic cystitis (mesna) |
|
|
Term
|
Definition
alkylating agent
activated by liver P450
hemorrhagic cystitis (mesna) |
|
|
Term
|
Definition
alkylating agent (nitrosourea)
crosses BBB!!! |
|
|
Term
|
Definition
alkylating agent (nitrosourea)
crosses BBB!!! |
|
|
Term
|
Definition
alkylating agent (nitrosourea)
crosses BBB!!! |
|
|
Term
|
Definition
alkylating agent (nitrosourea)
crosses BBB!!! |
|
|
Term
|
Definition
alkylating agents
crosses BBB!!! |
|
|
Term
|
Definition
alkylating agent
pulm fibrosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
alkylating agent
also MAOi, disulfuram-like reaction |
|
|
Term
|
Definition
| bind tubulin, block polymerization |
|
|
Term
|
Definition
| bind tubulin, block depolymerization |
|
|
Term
|
Definition
same as deoxycoformycin
inhibits adenosine deaminase -- hairy cell leukemia |
|
|
Term
|
Definition
alkylating-like agent (cross-links DNA)
nephrotoxicity (amifostine) and ototoxicity |
|
|
Term
|
Definition
| inhibits ribonucleotide reductase |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
same as pentostatin
inhibits adenosine deaminase -- hairy cell leukemia |
|
|
Term
|
Definition
same as 2-chlorodeoxyadosine
inhibits adenosine deaminase -- hairy cell leukemia |
|
|
Term
|
Definition
same as cladribine
inhibits adenosine deaminase -- hairy cell leukemia |
|
|
Term
|
Definition
| methylating agent, needs liver for activation |
|
|
Term
|
Definition
Herceptin
antibody against HER-2/erb-B2 |
|
|
Term
|
Definition
Cisplatin/Carboplatin --> ototoxicity
Vincristine --> peripheral neuropathy
Bleomycin/Busulfan --> pulm fibrosis
Doxorubicin --> cardiotoxicity
Cisplatin/Carboplatin --> nephrotoxicity
CYclophosphamide --> hemorrhagic cystitis
5-FU --> myelosuppression
6-MP --> myelosuppression
MTX --> myelosuppression |
|
|
Term
| multi-drug resistant cancers |
|
Definition
| MDR1 -- glycoprotein that is transmembrane ATP-dep efflux pump!! |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
