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pharmcology
pharmacology
15
Architecture
Kindergarten
10/07/2011

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Cards

Term
dopamine
Definition
D1, B1, a1 agonist
dilates renal and mesenteric
positive intoropic but little effect on heart rate
diuretic
treats shock, renal failure, CHF
Term
dobutamine
Definition
B1 ag
increase HR and contractility
CHF
tachycardia is major adverse effect
Term
phenylephrine
Definition
A1 ag
vasoconstrictor, decongestant, mydriatic, detumescent (reduces swelling)
reflex bradycardia is side effect
Term
clonidine
Definition
A2 ag
reduces sympathetic outflow to heart and causes vasodilation
hypertension, pain
causes bradycardia or rebound hypertension if withdrawn
Term
terbutaline
Definition

B2 ag asthma supress premature labor

adverse: hyperglycemia, tachycardia at high doses

Term
ephedrine
Definition
nonselective alpha/beta agonist
heart rate stimulant, bronchodilator, CNS stimulant
adverse--hypertension and inosomnia
Term
methylphenidate
Definition
indirect--promotes release of NE and DA and inhibits reuptake
ADHD, narcolepsy
similar cardiac effects to NE
insomnia, abuste,
Term
atomoxetine
Definition
inhibits NE reuptake
ADHD
less abuse
insomnia, tachycardia, suicidal thoughs
Term
alpha 1 BLOCKERS
Definition
TREAT:
hypertension, antidote to Epi, BPH, pheochromocytoma, reynaud's disease
Term
beta 1 BLOCKERS
Definition
Treat: hypertension, angina pectoris & MI, CHF, arrythmias, hyperthyroidism, glaucoma, migrain
Term
prazosin
Definition
a1 blocker
dilates arteries and relaxes smooth muscle of bladder neck and prostate capsule
no increase in HR
treats hypertension
adverse: fist dose at bedtime--first dose effect
inhibits ejaculation, nasal congestion
Term
tamsulosin
Definition
a1 blocker
little effect on bp
bph dudes can pee
abnormal 'jaculation
don't use'em wit vasodilators for ED--extreme hypotension
Term
propanolol
Definition
non-selective beta adrenergic blocker
competitive antagonist
don't use in diabetics or with (initial) heart failure, or with asthma
decreases heart rate and contractility
initial increase in peripheral resistance due to B2 block
B1-decrease renin release, promotes bronchoconstriction, inhibits glycolosis
Adverse: bradycardia, asthma aggravation, sexual dysfunction, fatigue
Term
metoprolol
Definition
B1 selective
hypertension, CHF, MI
Term
OTHER properties of beta blockers
Definition
some block A1 too!
differences in lipid solubility
intrinsic sympathomimetic activity--only partial agonists--little effect on HR and CO
local anesthetic due to ion channel blockade
additional properties like vasodilation and antioxidant effects
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