Term
|
Definition
increase cGMP --> vasodilate arterioles > veins
reflex tachy --> angina; reflex increased renin --> edema; SLE |
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Term
|
Definition
dihydropyridine CCB (L-type), esp on smooth muscle
for vasospasm (Raynaud's, Prinzmetal's angina)
peripheral edema, flushing |
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Term
|
Definition
non-dihydropyridines CCB (L-tpe), esp on cardiac muscle
type IV antiarrhythmic
constipation, gingival hyperplasia |
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Term
|
Definition
non-dihydropyridines CCB (L-tpe), esp on cardiac muscle
type IV antiarrhythmic |
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Term
|
Definition
dihydropyridine CCB (L-type), esp on smooth muscle
for vasospasm (Raynaud's, Prinzmetal's angina)
peripheral edema, flushing |
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Term
|
Definition
increase cGMP --> vasodilates arterioles AND veins!!
cyanide toxicity!! |
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Term
|
Definition
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Term
|
Definition
K+ channel opener --> hyperpolarize and relax vascular smooth mscle
hyperglycemia!! |
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Term
|
Definition
increase cGMP --> vasodilate veins > arterioles
reflex tachy, flushing, HA, "Monday disease", need nitrate-free periods daily to prevent tolerance |
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Term
|
Definition
increase cGMP --> vasodilate veins > arterioles
reflex tachy, flushing, HA, "Monday disease", need nitrate-free periods daily to prevent tolerance |
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Term
|
Definition
increase cGMP --> vasodilate veins > arterioles
reflex tachy, flushing, HA, "Monday disease", need nitrate-free periods daily to prevent tolerance
100% bioavailability!!! |
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Term
|
Definition
open K+ channels --> dilates arterioles
hair growth!!! |
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Term
|
Definition
inhibits HMG-CoA reductase --> increase LDLR on liver
hepatotoxicity, rhabdomyolysis |
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Term
|
Definition
bile acid resin --> prevent resorption of bile acids --> liver converts cholesterol to bile acids and increase LDLR and cholesterol prod
GI, malabsorption, gallstones, increase TG |
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Term
|
Definition
bile acid resin --> prevent resorption of bile acids --> liver converts cholesterol to bile acids and increase LDLR and cholesterol prod
GI, malabsorption, gallstones, increase TG |
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Term
|
Definition
bile acid resin --> prevent resorption of bile acids --> liver converts cholesterol to bile acids and increase LDLR and cholesterol prod
GI, malabsorption, gallstones, increase TG |
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Term
|
Definition
prevent cholesterol reabsoprtion
rare elevation in LFTs |
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Term
|
Definition
fibrate -- upreg LPL --> increased TG clearance
myositis, hepatotoxicity, gallstones (inhibits 7alpha-hydroxylase), competes with warfarin for plasma proteins |
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Term
|
Definition
fibrate -- upreg LPL --> increased TG clearance
myositis, hepatotoxicity, gallstones (inhibits 7alpha-hydroxylase), competes with warfarin for plasma proteins |
|
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Term
|
Definition
fibrate -- upreg LPL --> increased TG clearance
myositis, hepatotoxicity, gallstones (inhibits 7alpha-hydroxylase), competes with warfarin for plasma proteins |
|
|
Term
|
Definition
fibrate -- upreg LPL --> increased TG clearance
myositis, hepatotoxicity, gallstones (inhibits 7alpha-hydroxylase), competes with warfarin for plasma proteins |
|
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Term
|
Definition
inhibits Na+/K+ ATPase; stim vagus n.
toxicity -- blurry yellow vision, N/V/D, prolonged PR/decreased QT/scooping/T-wave inversion/arrhythmia/hyperK
worse with renal failure (less excretion), hypoK (less competition for ATPase), quinidine (competes for albumin) |
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Term
|
Definition
| recombinant BNP --> increased cGMP --> vasodilation |
|
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Term
|
Definition
| inhibits phosphodiesterase III --> increased cAMP --> inotropy AND vasodilation |
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Term
|
Definition
| inhibits phosphodiesterase III --> increased cAMP --> inotropy AND vasodilation |
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Term
|
Definition
Class IA antiarrhythmic -- blocks Na+ intermediately and some K+ --> prolonged QT
cinchonism = HA + tinnitus |
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Term
|
Definition
Class IA antiarrhythmic -- blocks Na+ intermediately and some K+ --> prolonged QT
SLE |
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Term
|
Definition
| Class IA antiarrhythmic -- blocks Na+ intermediately and some K+ --> prolonged QT |
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Term
|
Definition
Class IB antiarrhythmic -- blocks activated AND inactivated Na+ weakly --> short QT
for post-MI and dig-toxicity
IB = Best post-MI |
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Term
|
Definition
Class IB antiarrhythmic -- blocks activated AND inactivated Na+ weakly --> short QT
for post-MI and dig-toxicity
IB = Best post-MI |
|
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Term
|
Definition
Class IB antiarrhythmic -- blocks activated AND inactivated Na+ weakly --> short QT
for post-MI and dig-toxicity
IB = Best post-MI |
|
|
Term
|
Definition
Class IC antiarrhythmic -- blocks Na+ strongly, no change in QT
IC = Contraindicated post-MI |
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Term
|
Definition
Class IC antiarrhythmic -- blocks Na+ strongly, no change in QT
IC = Contraindicated post-MI |
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Term
|
Definition
Class IC antiarrhythmic -- blocks Na+ strongly, no change in QT
IC = Contraindicated post-MI |
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Term
|
Definition
Class IC antiarrhythmic -- blocks Na+ strongly, no change in QT
IC = Contraindicated post-MI |
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Term
|
Definition
| Class III antiarrhythmic -- blocks K+ channels --> prolonged QT |
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Term
|
Definition
Class III antiarrhythmic -- blocks K+ channels --> prolonged QT
also beta-blocker properties |
|
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Term
|
Definition
| Class III antiarrhythmic -- blocks K+ channels --> prolonged QT |
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Term
|
Definition
Class III antiarrhythmic -- blocks K+ channels --> prolonged QT
check PFTs, LFTs, TFTs!!
has class I, II, III, and IV activity
does NOT increase risk of torsades |
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Term
|
Definition
| Class III antiarrhythmic -- blocks K+ channels --> prolonged QT |
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Term
|
Definition
increase K+ current --> hyperpolarize cell at AV node --> complete heart block!!
drug of choice for SVTs
flushing, hypotension, CP
blocked by theophylline!! |
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Term
|
Definition
dihydropyridine CCB (L-type), esp on smooth muscle
for vasospasm (esp after SAH!!)
peripheral edema, flushing |
|
|
Term
|
Definition
1. lifestyle modification
2. statin
3. ezetimibe |
|
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Term
|
Definition
1. lifestyle modification
2. niacin |
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Term
|
Definition
1. lifestyle modification
2. fibrates
3. niacin |
|
|
Term
| cholesterol stuff you should check LFTs for |
|
Definition
| statins, ezetimibe, fibrates |
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|
Term
| cholesterol stuff you can get gallstones with |
|
Definition
| bile acid sequestrants, fibrates |
|
|
Term
| cholesterol stuff you can get muscle stuff with |
|
Definition
|
|
Term
|
Definition
inhibits lipolysis --> less VLDL precursors --> less VLDL secretion --> less LDL
flushing (2/2 prostaglandins --> prevent with ASA), hyperglycemia, hyperuricemia |
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Term
|
Definition
| good for torsades and dig toxicity |
|
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Term
|
Definition
2 --> RA, RV
3 --> LV (RA --> coronary sinus along post AV groove --> lateral venous tributaries) |
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|
Term
|
Definition
LAD only -- internal mammary
saphenous vein -- take from femoral triangle |
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Term
|
Definition
the Queen Proclaims Diso's pyramid
Quinidine
Procainamide
DisoPYRAMIDe |
|
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Term
|
Definition
i'd buy LIDy's MEXIcan Tacos
LIDocaine
MEXIletine
Tocainide |
|
|
Term
| Class III antiarrhythmics |
|
Definition
K IS BAD
Ibutilide
Sotalol
Bretylium
Amiodarone
Dofetilide |
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