Shared Flashcard Set

Details

Pharm- ADHD
Psych week 3
24
Medical
Graduate
08/22/2018

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Cards

Term
What is the average age of diagnosis for ADHD?
Definition
7
Term
Brain area deficits in ADHD?
Definition
Prefrontal cortex, anterior cingulate cortex, ventral striatal region
Term
How long does hyperactivity have to persist for diagnosis of ADHD?
Definition
>/= 6 months
Term
In how many settings does the child have to display symptoms to be diagnosed w/ ADHD?
Definition
>/= 2 settings
Term
Before what age do symptoms have to develop in order for pt. to qualify as having ADHD?
Definition
12
Term
Three core symptoms of ADHD?
Definition
Hyperactivity, impulsivity, inattention
Term
Which dietary supplement may be helpful as an adjunct for ADHD treatment?
Definition
Omega-3 fatty acids (FDA- approved supplement = Vayarin)
Term
Methylphenidate MOA?
Definition
Blocks dopamine transporters (minimal effect on NE)
Term
Which stimulant med is older?
Definition
Methylphenidate
Term
Amphetamine MOA?
Definition
Stimulate release of DA, NE (and 5HT at high doses)
Term
Which stimulant med should be prescribed for a child w/ ADHD between 3 and 6 y.o.?
Definition
Amphetamine IR (ER and methylphenidate only approved > 6y.o.)
Term
Can methylphenidate Immediate Release be crushed or split?
Definition
Yes
Term
What is the brand name for transdermal methylphenidate patch?
Definition
Daytana
Term
should amphetamine be taken w/ orange juice?
Definition
No; vitamin C blocks absorption
Term
Which stimulant has the highest potential for abuse due to the feeling of euphoria it illicits?
Definition
Methamphetamine salts (Adderall)
Term
Which stimulant is a prodrug that gets converted in the gut (lowest risk for abuse)?
Definition
Lisdexamphetamine
Term
Atomoxetine MOA?
Definition
Selectively inhibits NE reuptake
Term
How long is the onset of atomoxetine?
Definition
1-4 weeks
Term
Rare/serious adverse fx of atomoxetine?
Definition
MI, hepatotoxicity, priapism
Term
Examples of alpha-2 agonists?
Definition
Guanfacine, clonidine
Term
MOA of alpha-2 agonists?
Definition
Inhibit presynaptic NE release & increase blood flow to prefrontal cortex
Term
What wake-promoting stimulant is not FDA approved for ADHD due to risk of SJS?
Definition
Modafinil
Term
Stimulant drug interactions?
Definition
Methylphenidate & amphetamine- MAOis
Methylphenidate- TCAs
Amphetamine- 2D6 inhibitors like paroxetine
Term
Drug interactions of alpha-2 agonists?
Definition
BP-lowering meds
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