Term
| Inhibition of bacterial cell wall synthesis |
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Definition
Pencillins, cephalosporings, imipenem/meropenem, aztreonam, vancomycin
(These are cidal drugs) |
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Term
Inhibition of bacterial protein synthesis
(static) drugs |
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Definition
| Aminoglycosides (cidal), chloramphenicol, macrolides, tetracyclines, streptogramins, linezolid, clindamycin |
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Term
Inhibition of nucleic acid synthesis
(cidal drugs) |
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Definition
| Fluoroquiolones, rifampin |
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Term
| Inhibition of folic acid synthesis |
|
Definition
| Sulfonamides, trimethoprim, pyrimethamine |
|
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Term
|
Definition
| They interact with cytoplasmic membrane binding proteins (PBPs) to inhibit transpeptidation reactions involved in cross linking in the final steps of cell wall synthesis. |
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Term
| Mechanisms of resistance to pencillins |
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Definition
1. Penicillianses (beta lactamases) break lactam rind structure- seen with staphylococci
2. Structure changes in PCPs seem in MRSA and penicillin-resistant pneumococci
3. Change in porin structure- pseudomonas |
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Term
| Narrow spectrum Penicillins |
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Definition
1. These are beta lectamase sensitive
2. Pencillin G and Penicillin V
3. Uses include- streptococci, pneumococci, meningcocci, Treponema Pallidum
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Term
|
Definition
1. These are Beta-Lactamase sensitive
2. Naicillin, Methicillin, and Oxacillin
3. Very good against staphlyococci (s. aureus) |
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Term
| Broad Spectrum Pencillins |
|
Definition
1. Aminopenicillins, beta lactamase sensitive
2. Ampicillin, Amoxicillin
3. These are good against gram (+) cocci & rods, but not staph, gram (-)
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