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Pharmacology
Heart
17
Chemistry
Undergraduate 2
03/19/2009

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Cards

Term
inotropic effect
Definition
influnce the force of contraction of heart
Term
chronotropic effect
Definition
influence rate of contraction of heart
Term
dromotripic effect
Definition
influence rate of conduction of electrical impulses
Term
cardiac outpit
Definition
efficiency of the heart as a pump, measured in liters/minute
Term
Cardiac output equation
Definition
CO = SV x HR
Term
Normal CO
Definition
3.5-8.0 liters/minute
Term
Normal heart rate
Definition
60-80 beats/min
Term
How hr is decreased
Definition
PNS via vagus nerve
Term
how HR is increasedd
Definition
SNS-> catecholoamine release -> B1 stimulation -> increased hr and contractility
Term
Stroke volume
Definition
amount of blood pumped out with each beat, normal value = 70 mls, determined by preload, afterload, contractiliy
Term
preload
Definition
volume achieved during diastolic filling of ventricles, depended on venous return
Term
what factors of drugs will increase preload?
Definition
-increased fluids, vasoconstrictors, increasing venous return
Term
what factors or drugs will decrease preload?
Definition
lose volume, diuretics, dilation of blood vessels
Term
afterload
Definition
force, resistance, how hard heart works to get blood to periphery (depends on blood pressure and peripheral resistance)
Term
contractility
Definition
force of contraction. Inotropic response
Term
cardiac worklod
Definition
effor the heart expends to pump blood, as increases so does O2 demands (hypertension, increased HR and catecholamines)
Term
raroreceptor reflex
Definition
pressure sensitive receptors in the walls of blood vessels and ehart and respond to changes in strech of walls. Fall in BP -> increase HR and vasoconstric (reflex tachycardia)
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