Inhibit peptidoglycan synthesis

Ambulence w/big red cross on side, slams into brick wall, inside pt on IV, catheter.  Loud sounds. 

G+, petidoglycan bricks, renal excrete, nephrotox, hearing loss.

Inhibit peptidoglycan synthesis

Poly and Neo traces my top.

Polymixin and neomycin (aminoglyco), like vancoMYcin, topical.

Inhibit corss linking via transpeptidase

Gimme peppy cheerleader Penny!  Her very good oral irreversibly broke Pro Benjy Clavicles, so they augmented w/Mox.

Pen G = IM, transpeptidase, no brain, Penicillin, V = Oral, Irrev inhib, Pro and Ben G lwo levels for long time, give with Clavulanic Acid. Amox + Clav = Augmenten.

Inhibit cross linking via transpeptidase

Cell wall

More broad and expensive later generations.  Third on CNS (3 on side looks like brain hemis).  First = ph's (ceph, G+), 2nd = Cefaclor (G-), 3rd = Ximes (Cefotaxine, cefixime, G- and anaerob, CNS), 4th = Pimes (Cefepime)

B lacatams:

Carbapenems

Monobactams

Others

Inhibit cross linking via transpeptidase

Cell wall

Broad car comes w/stats that chill blood (broad in all, combo w/cillistatin that inhib renal enz that munch drug, IV only).

Mono: broad neg, narrow +, G+ staph, IV only

Spoore does acid betta and can use one pen w/a carb.

(Cephalosporins, clav acid, beta-lactam, monobactum, penecillins, carbapenem = beta lactams 

Detergent for Cell Membrane

Cheerleader poly skinny w/tropical tan mixes it up with the guys, girls give negative looks, would love to cut her down and punch in kidneys.

No CNS, polymixin, narrow, topical w/bacitracin, G-, surg and nephrotox.

Disrupt fungal sterols directy

X-Fung

Poly got fungus....Ene = Ergost

Disrupt fungal sterols directly

Amphoterrible!!!  Terrorists bomb your members, take out your kidneys and drain you of your blood.

Cell membrane, IV only, nephrotox.

Need ergost as receptor

Disrupt fungal sterols directly

Nice tan terrible for kids.

Only topical, like amphoterrible but worse nephrotox.

Azole: inhibit synthesis of sterold in fungal membranes 

Leaky Cell Mem, less sterols (block precursor from becoming ergost)

Cute idiot assholes eat acid (low pH helps), stops p450 from working on others, no CNS, 50/50, cause girls to become anorexic.  Don't like pump up bras. (proton pump blocks absorb)  

Itra and Fluco not dependent on pH, renal excrete, IV

Terbinifine

Allylamine X-Fung

Stops fungal growth on skin, hair, and nails

Ally squeales @ terby the azole for stopping amphoterrible.

Allyamine, Oral, blocks squalene from becoming ergost, terbinifine, like azoles, stops ampho B that needs the ergost as receptor

Metabolized to active 5-FU in fungal metabolism

Cell mem

Deam to 5-FU

Fungus brains yell "FU!" for pumping iron.

To CSF, oral, deam to 5-FU, drug facilitates making pump to pump self out of cell (tricky), give anemia, anti-fungal 

Inhibit gyrase/topoisomerase needed for DNA synthesis

Nuc Acid synth

Flora not an airhead but she sucks @ sexy dancing, when I watch her on Skype I get soo excited I pee my pants, moves like that should not be shown to kids.

Fluroquni, not anaerobes, G-, UTIs, gyrase/topoisom, ESE skype ones (G- baccili), CNS hyperactive, renal excrete, not for kids <16/17 b/c cartilage damage.

Inhibit RNA pol

Nuc acid synth

R's....RNA pol, G pRo, oRange, all oveR, excRement, otheR drugs, teRatogenic, Renal issues,

Cfhange DNA's use as template

Nuc Acid one

Nitros explosive fury is soo scary I can't brethe, pee pants and turn em brown.

Damage DNA b/c highly reactive intermediates, active in urine, UTI, pulmonary fibrosis (rare), pee brown

Inhibit protein synthesis, cause misreading of genome.

A mean old meat eating negative (seldom happy) gentleman gets confused, can't pee, can't see, can't move, needs bifocals, lead full life, resists in AM TO the NET

Aminoglycoside, prot synth, G-, some G+, gentimycin, wrong AA incorp, renal tox (drinks lots of water), otot tox, block NMJ, biofilm form, FULL DOSE, resistance common, Amik (1st line in resist) then Tobra then Netilmycin

Bind 30s to block tRNA binding

Tet offensive, nervous soldier, napalm burns skin, photosense, 30s grenade takes out liver, brown teeth.  Broad shoulders, lots bact.  Others oxytetracyclin, minocycline, doxycycline.

30s ribo, VERY broad, oral or IV, not IM (irritate), GI and hepato (minor), brown teeth, cross placenta, superinfection, phototox,

Use: actinomycetes, rickets, mycoplasma, chlamydia, entamoeba histolica.

Block 50s, block peptide formation.

A plastic purple pancake chloroformed 50 broad babies w/rickety hearts.

Aplastic anemia: purpura, pancocytopenia, kills, 50s, broad, cardiotox in babies (can't conj to glu), rickets 

Block 50s, blocks peptide formation

Big hats music lable looks to sign 50 people likes Pen G, erythro is shit b/c wears stupid coat, Clair is best b/c can do it all but can't out do Azi (more broad, longer, higher), has bad news and tells can't see future, bad tasts about them, drink to much and damaged liver, so only in serious cases will he use them.

Macro-lids, Pen G like, (G+ most, G- some), 50s, erythro: feces only, enteric coat, Clar: broad, newer, Azithro: better oral, more broad, PK longer, higher in tissues, Telithro: oral, liver met, bile/feces, GI issues, headache, blurred vision, alter taste, HEPATOTOX only for serious resp infects. 

Bind diff 50s, blocks peptide formation AND tRNA binding

50 year old Reta transfered to tropics b/c couldn't handle the stress of her staph.

Topical, 1st in while, 50s, tRNA transfer is unique, staph, strep.

Bind 50s, prevent protein synthesis

Protein Inhib

Airhead Clindy raised very bad kids.

Aerobes, change w/renal issues, severe SE's.

Bind 50s

Pristine Quin's bloody farts vanquish 50 painful trombones.

(I can't stomach bad music!!!)

IV only, feces out, Vanco resist, bind 50s, pain: myalgia and arthralgia, thrombophlebitis, NO GI. 

Bind 50s, block formation of 70s

Protein synth

Can't form 70 lines off pristine gold plated urinal.

Block 70s, broader than pristins, G+, monitor platelets, urine out.

Block folic acid synthesis: PABA

Slufa SNACK = SIC PUPIL

Sulfonamides, Solubility, NaHCO3, Acitve in urine, CNS, Keratoconjunctivitis, Static, Inhib all, crystaluria, PABA, ureine, insol = problem, low iron

Inhibit dihydrofolate reductase (DHF to THF)

Tri meth and payably on death!!!

PABA, Others (not alone), dihydrofolate reducatse.

Fungi deaminates to 5-FU to block DNA synthesis

Fluke fungi wear TOGA's,

Flucytosine, fungi met to 5-FU, Total body water, Oral, goes better than Ampho,

Decompose to formaldehyde in urine

Meth's MAL enemies are formaldehyde BAGS

Methenamine, mandelic acid, acetic acit, low pH, decompose to formald, broad (G+ and G-), Active in urine, GI, DON'T MIX W/SULFA!!!!

UTI tx w/nitro

Guanosine analog, -DNA synth

Without cycles, guam would get herper viruses from big bars.

Acyclo, guanosine, herpes (*), x-viral, CMG, Ep-Barr

Guanosine analog

More babies are hurt by guam bike gangs than big herpes.

TERATOGENIC!!!, guan nuc analog, CMV and Herpes (*).

Thymidine analog

Iditarod thyme is toxic to eyes.

Thym anaglog, toxic to mammals, use in non-replicating like eyes.

Adenosine analog

Herpes aids vibrators w/bikes.

Herpes, Adenosine, Vibarabine, combo w/acyclo.

Adefovir

Didivoxil

Adenosine analog

Adeno Didi polls for Hep B.

Adenosine, inhib pol, Hep B.

Inhibit M2 Channel protein

If an affluent man is 2 hard headed it's a big problem and makes it hard to resist.

Flu A, blocks M2 for uncoat, CNS (1/3), light headed can't concentration, resistnace is big problem.

Inhibit neuramidase enzyme (virus needs to enter cells)

Oselots changed mind, and hesitantly flew away.

Change confirm of neuramidase, resist H5N1 receptor = problem (can get during tx), use in aman resist.

Inhibit neuramidase enzyme

Flus don't change zany noses.

Flu A and some B, no confirm change, intranasal/dry powder, in osel resist.

Cytidine analog, non-nucleoside inhibition of DNA pol and reverse transcriptase

Lami wheezed like zany person she was.  Liked to site her days doing reverse dives straight as a pole.  HEP HEP HORRAY!!!

Wheezing/bronchospaz, cytidine, non-nuc inhib of DNA pol and reverse txt-ase, same as osel w/out confirm change, HepB, HIV, renal.

Nevirapine

Efavirenze

Inhibit reverse transcriptase

I thought Efrain had HIV, made big side show of it but it was all in my head.

HIV (w/nevirapine), SE's are BIG, CNS problems.

Inhibit enzyme that cleaves viral polyprotein to active form

Indians get excited about cleaving protstors for their sugar and fat.

Protease Inhib

Cleavage needed to become active, get diabetes issues, hyperglycemia, fat redist and hyperlipidemia.

Enfuvirtide

Maraviroc (Celsentri)

POLYPEPTIDE blocks viral fusion to CD4

4 expensive fufu's became friends w/Celeste and Mira for her recent 5 mil.

Enfu is expensive and inhibits fusion w/CD4

Mara/Celest recent for CCR5 coreceptor, also fusion inhib.

Cyclophosphamide

Doxorubicin

Monoclonal Ab silences Her2 w/PTEN and sarc.

Pho Docks get 10 pack Abs from biking.

PTEN (and sarc) needed, like herceptin, monoclonal Ab.  

Monoclonal Ab against B cell lympocytes

Tucks glasses in bag.

Tux, monoclonal, B cells. 

TK inhibition

Chicken Tika w/glee and get asS PErCh.

Chronic myeloid leuk, TK inhib, Gleevec, Small Molecule, Penias (Thrombo and Neutro), Edema, Cramps, rash  

Monoclonal Ab against EGFR

Skinny Erb's tux grows Krass and stops bleeding.

Combo small molecules, Erbitux, Kras drives cell prolif, stops angiogenesis.

Block TK mediated growth factor EGFR

TK gets fit, bulkier, better @ breathing, stops skin mutations.

TK  mediated by growth signal is inhib, Getfit, in lung cancer, EGFR mutations (who responds to tx vs doesn't)

Monoclonal Ab targets VEGF and inhibits angiogenesis

Bev's students are sore about veggies.

Stutent and Srafenib also TK inhibs, small molecules for VEGF inhib

Management stops alkys

Stops alkylation damage

Metabolomic Profiles

Stopping Nause/Vomit

Dads cosign $ for Lexi who then pukes on deck and pisses them off.

Dads w/aggressive prostates have more sarcosine, Dolasteron (Anzemet), Aloxi (Palonosetron), inhib nause and vomit as serotonin reeptor antagonist, Dexamethasone (Cortocosteroid) also may work.  Have their own side effects.