Shared Flashcard Set

Details

Pharmacology
Test III
80
Pharmacology
Undergraduate 4
12/02/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Drug used for hypertensive emergency
Definition
Vasodilators; Minoxidil (loniten), diazoxide (hyperstat IV), sodium nitroprusside (Nitropress). Vasodilators decrease the workload of the heart. Can dilate the arterioles and/or veins
Term
PT ed with nitroglycerin
(organic, stable/variant angina, vasodilator)
Definition
Do not withdraw abruptly, S/S of orthostatic HTN, HA (when applying ointment-wear gloves), tachycardia, flushing, dizziness, rash w/patches
Term
Assessments with pt on diuretics
Definition
monitor BP, diet high in potassium, monitor fluids (retention), S/S dehydration, potassium supplements, orthostatic HTN, thirst is SE, take with meals, report wght gain/loss, monitor I&O
Term
Pharmacologic goals for treatment of angina
Definition
Prevent MI or death and anginal pain
Term
Pt ed for pts taking antidysrhythmics drugs
Definition
Patient skilled in taking pulse, recognize health status changes, reduce CV risk factors, avoid alcohol, common SE-diarrhea, med ID tag
Term
Beta-blockers and pts with COPD
Beta-blocker-DOC---Propranolol
Definition
Causes bronchospasms (inderal)-should be used caution
Term
Lab tests for heparin and coumadin
Definition
Heparin-PTT (Partial thrombosplastin time) 20-
30sec
Coumadin-PT (Prothrombin time) 12-15sec
INR (International normalized ratio) 2.5
Term
Antidotes for heparin and coumadin
Definition
Vitamin K/protamine sulfate
Term
MOA of heparin
Definition
Suppresses coagulation by helping antithrombin inactivate clotting factors-thrombin & factor Xa. Administer by injection only
Term
Process for changing pt from heparin to coumadin
Definition
Never just stop heparin; start coumadin while weaning off heparin
Term
DOC for PE
Definition
Warfarin-an oral anticoagulant-prevention
Heparin-911 onset
Term
Uses for Ticlid (Ticlopidine)
Antiplatelet Drug
Definition
Prevention of thrombotic stroke
Term
When best to give a tissue plasminogen activator (time frame) uses: MI, ischemic stroke or PE
Definition
Not given if pain present for more than 12hrs; best if given within 4-6 hours; guidelines suggest w/i 30min.
Accelerated: Front-loaded schedule; scheduled infusion time is 90 minutes compared to 3 hours in the past
Term
Drug for pain/HA etc if taking coumadin
Definition
NO NSAIDS
Take Tylenol-Acetaminophen
Term
MOA of ASA
First Generation NSAIDS
Definition
Nonselective inhibitor of cyclooxygenase; Reductions in pain & inflammation-inhibiting COX2
Protection against MI and ischemic stroke-inhibiting COX1
Term
MOA of epoetin alfa-growth factor-erythrocytes (RBCs)
Definition
produced by recombinant DNA technology; protein is identical to human erythropoietin-a natural hormone. Stimulates bone growth
Term
Assessment with pt taking digoxin (also) when to give and not give
Definition
Monitor pulse (full minute) prior to administration; hold medication if pulse is <60-call Dr.
Term
Pt teaching with ACE inhibitors---esp with orthstatic hypotension
Definition
Low blood pressure=orthostatic hypotension, especially with elderly-fall risk. SE=cough
Term
Pt ed with cholesterol lowering drugs---esp with how to increase HDL
Definition
Diet/exercise is first line of therapy - best way to increase HDL. Statins have greatest impact when given daily at night. Have patient limit cholesterol and saturated fat.
Term
SE of nitroglycerin---causes of headache
Definition
Wear gloves when applying ointment; dosing may be too high
Term
MOA of digoxin
Definition
Profound effect of the electrical and mechanical properties of the heart; increase mycardio contractility, which increases blood to the kidneys-which increases urine, increases CO
Term
Major obstacles to successful chemotherapy
Definition
Death of healthy cells, cure=100% kill, absence of early detection, solid tumors respond poor, drug resistance, limited drug access to tumor cells
Term
Why used of Allopurinol in chemotherapy
Definition
increases amounts of uric acid-hyperuricimia that develops secondary to cancer chemo-cells dye=breakdown of DNA releases uric acid-administer before starting chemo
Term
SE of Crestor
Definition
Myopathy; rhabdomyolysis...S/S unexplained muscle pain/stiffness
Term
When pt should take a diuretic (MOA)
Definition
Take early in the morning to minimize nocturia, when taken 2x p/d; take at 8am and 2pm; restrict K-rich food-nuts, dried fruit, spinach, citrus fruit, potatoe or bananas
Term
Pt ed and diuretics
Definition
stress diet unless on K sparing diuretic, monitor BP, pulse, weight, take med immediately if missed. Signs of dehydration, id tag
Term
MOA of diuretics
Definition
Blocks Na+ and chloride reabsorption
Term
Assessment with Pt taking diuretics
Definition
BP, pulse, dehyd, weight,
Term
SE of verapamil (Calan)
Definition
Constipation
Term
MOA of Imodium
Definition
tx diarrhea, reduce fluid vol/discharge from ileostomy. Allow fluid absorption.
Term
MOA of Antacids
Definition
Neutralize acids and prevent the conversion of pepsinogen to pepsin in the stomach; react with gastric acid to produce neutral salts or salts of low acidity; enhance mucosal protection by stimulating production of prostoglandins
Term
SE of Amphogel
Definition
Constipation and diarrhea
Term
MOA of H2 antagonists
Definition
Promote healing by suppressing secretions of gastric acid; decrease amount of acid in stomach
Term
Goal of antineoplastic therapy
Definition
decrease size of neoplasms so immune system can deal with it, may include cure, decrease tumor size, relieve symptoms, kill metastisis cells, prolong life.
Term
SE of Chemo (severe)
Definition
N/V, diarrhea, toxicty, neutropenia, thrombocytopenia, bone marrow suppression, anemia
Term
Best way to treat GERD
Definition
Suppressing secretions of gastric acid, PPIs (protein pump inhibitor) most effective drug
Goals: eleviate complications/symptoms, heal, prevent complication and reccurrence
Term
MOA of Colace
Definition
Stimulate intestinal motility, increase amount of water and electrolytes in the intestinal lumen; used for opioid induced constipation/constipation from slow intestinal transit
Term
Nsg interventions of stomatitis assoc with chemo
Definition
include oral hygiene, bland diet, topical oral antifungal drugs for infection. Mild: mouthwash with topical antisthetic and antifunal, severe case: use of opiods.
Term
Why combination chemotherapy
Definition
Drug combo benefit, suppression of drug resistance, increased cancer kill (different cycles of the cell), reduction of injury to health cells. Growth fraction of the cells
Term
Meaning of cell cycle specific in chemotherapy
Definition
Cells have phases, -when specific, only toxic to cells that are in a particular growth phase-must be in blood for a long period of time
Term
Type of laxative for pt lacking fiber in the diet
Definition
Bulk-forming; functions like dietary fiber-swell with H2o to form a gel to soften the fecal mass and increase the mass. METAMUCIL
Term
SE of 1st generation antihistamines
Definition
Drowsiness/sedative (Benedryl)
Term
When not to give antihistamines
Definition
Pregnant or lactating women; monitor elderly and children
Term
ASA and Pt having surgery
ASA Promotes bleeding inhibits platelet aggregation
Definition
For surgeries where lots of bleeding is possible, discontinue high doses of aspirin one week prior to procedure. For low-bleeding risk surgeries (dental); there is no reason to discontinue aspirin therapy.
Term
SE of COX-2 inhibitors (major)
Definition
Cardiovascular risks; MI & stroke. Dyspepsia, abd pain, renal toxicity.
Term
Uses of COX-2 inhibitors
Definition
Osteoarthritis, rheumatoid arthritis, acute pain, dysmenorrhea, familial ademonatous polyposis
Term
Pt Assessment and pts taking glucocorticoids
Suppress immune response/prevent rejection
Definition
Increased risk for infection, thinning of skin, bone dissolution with fx, impaired growth in children, suppression of hypothalamic-pituitary-adrenal axis
Term
How to take pts off of steroids
Definition
Taper off gradually
Term
Who should not be taking high dose steroids
Definition
Ptnts with systemic fungal infections; receiving live virus vaccines, pediatric patients & pregnancy/breast-feeding
Term
Purpose of vaccines
Definition
Give patient antigen and hope they develop antibodies
Term
Pt ed with cyclosporine
Definition
AVOID grapefruit juice-increases response; more likely to experience SE
Term
SE of cyclosporine
Definition
nephrotoxicity, infection, HTN, sinusitis, hyperkalemia, anaphylactic reactions
Term
Med for children prior to getting immunizations
Definition
Tylenol-Acetaminophen
Term
SE of Prandin
Definition
Hypoglycemia; must eat w/i 30minutes of taking
Term
Reason for tight control of BG in DM
Definition
To achieve primary goal-prevent long-term complications; reduction in microvascular complications; greatly reduces mortality and morbidity
Term
Reason to rotate injection sites with insulin admin
Definition
minimize adverse local reactions; formation of hollows or depressions in the skin "orange peel"
Term
MOA of insulin
Definition
promote cellular glucose uptake and metabolism
Term
Labs with metformin
Definition
hepatic and renal function tests, blood glucose levels, vit b12 and folic acid levels
Term
Beta blockers and hypoglycemia
Definition
Drug interaction/block the bodies interpretation of hypoglycemia. Increase effects of insulin.
Term
Type of insulin used for IV admin
Definition
Regular
Term
Onset of NPH insulin
Definition
3-4 hours
Term
Benefit of using long acting glargine insulin
Definition
provides basal level of insulin throughout the night and the following day; provides tight glucose control. levels steady over 24 hrs. reduce hypoglycemia.
Term
When to check BS level when switching from insulin to an oral hypoglycemic drug
Definition
more frequently, additional teaching needed
Term
SE of antacids
Definition
rx w/gastrica acid to produce neutral salts/salts w/ low acidity, decrease destruction of gut wall, enhance mucosal protection stimulating production of prostaglandins, prevent the conversion of pepsinogen to pepsin in stomach
Term
SE of Amphogel
Definition
constipation or diarrhea, caution in renal impaired pt., may prevent the absorption of other meds, can cause retention of K
Term
MOA of H2 antagonists
Definition
Decrease amt of acid in the stomach, want to use up the H so pt doesn't make more HCL, promote healing by suppressing secretions of gastric acid
Term
CHF treatment goals relief of symptoms......
Definition
slowing HR, increasing contractility, reducing cardiac workload
Term
Epoetin
Definition
Stimulates bone marrow to produce red blood ells
Term
Neupogen
Definition
TX of chemo induced neutropenia
Term
Neumega
Definition
Prevent thrombocytopenia
Term
Leukine
Definition
Decrease neutropenia and risk of infection
Term
Neulasta
Definition
Increase number of leukocytes
Term
Patient teaching storage for Insulin
Definition
do not freeze, keep in fridge, after opening-good for one month, keep out of direct sunlight and extreme heat
Term
Metformin MOA-Diabetes
Definition
decreases appetite, inhibits glucose production in liver; reduces glucose absorption slightly in gut
Term
SE Glinides
Definition
Hypoglycemia
Term
S/S Hyperglycemia
Definition
drowsiness, red/dry skin, fruity breath, anorexia, abdominal pain, N/V, dry mouth, increased urination, rapid-deep breathing, thirsty, weight loss
Term
S/S Hypoglycemia
Definition
Increased anxiety, blurred vision, chilly, cold sweating, pallor, confusion, difficulty concentrating, drowsiness, HA, nausea, increased pulse, shakiness, increased weakness, increased appetite
Term
Nursing Teaching-insulin has which drug effect?
Definition
Enhances carbohydrate metabolism
Term
Mgmt of STEMI
Definition
MONA B
Morphine, O2, Nitroglycerin, Aspirin, Beta Blockers
Term
Routine meds for MI
Definition
MONA B
Morphine, O2, Nitroglycerin, aspirin, beta blockers
Supporting users have an ad free experience!