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What type of tolerance means: tolerance to one equals tolerance to all others? |
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depresses the activity of the central nervous system and is used to relieve anxiety and induce sleep. |
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What was the first sedative hypnotic? |
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1902; first barbituate; barbital |
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1912; first commercial use sedative hypnotic |
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1950; minor anti-neurotic, major anti-psychotic |
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1960; first benzodiazepine |
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Barbituates are dependent upon? |
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Definition
-dosage -route of admin -absorption rate,distrubution,metabolism,excretion -behavorial state of individual |
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Barbituate Classifications: (half lifes) |
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Ultra-Short: 30 secs to 5 mins Short: 5 mins to 3 hrs Intermediate: 3-6 hours Long: up to 10 hrs Ultra Long: up to 3 days (can test in urinalysis) |
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Fat soluble vs Water soluble barbs |
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Fat-- Short duration; quick absorption Water-- Longer duration; slow absorption |
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