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Pharmacology
Lecture 2
8
Other
Graduate
01/28/2009

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Cards

Term
What are the classifications for antiarrhythmic drugs? And what is the main difference b/w these?
Definition
1a, 1b, 1c, II, III IV

Class 1 = have something to do with Na+
Class II = B blocker
Class III = K+
Class IV = Ca++
Term
Class Ia agents:
Definition
Slow conduction velocity
Prolong refractoriness
Decrease the autonomic properties of sodium-dependant conduction tissue
Intermediate “on/off” activity
Not widely used due to risk of toxicity
Quinidine = Diarrhea, headache, Torsades de pointe
Procainamide = Lupus-like syndrome
Disopyramide = exacerbate heart failure, Anticholinergic effects
**Very broad spectrum (for atrial and ventricular arrhythmias)
Term
Which medication class is most recommended for A-Fib or A-Flutter?
Definition
B blockers
Term
Type IV antiarrhytmic drugs, inhibit what ion? Which slows ___ & prolongs ___?
Definition
They inhibit Ca2+ ions from going into the myocardial cell, which slows conduction & prolongs the refractory period.
Term
What drug has been recommended as first choice in pt's with PSVT?
Definition
Adenosine
Term
For ventricular proarrhythmia, what often causes it, and what 2 drugs may help?
Definition
It is often caused by Type Ia and/or Ic antiarrhythmic drugs, and lidocaine or sodium bicarbonate may have success.
Term
What is the drug of choice for Torsade de Pointe?
Definition
Magnesium Sulfate
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