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Pharmacology
Second Exam
54
Other
Undergraduate 3
10/05/2008

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Cards

Term
Barbituate Prototype
Definition
Phenobarbital (Nembutal)
Term
Benzodiazapine Prototype
Definition
Lorazepam (Ativan)
Term
Misc CNS Depressant Prototype
Definition
Zolpidem (Ambien)
Term
Contraindications to alprolazam therapy
Definition
Pregnancy and lactation
Term
Contraindications to Chlorpromazine (Thorazine)
Definition
Alcohol w/d, comatose, Reyes syndrome, lactation
Term
S/E of Phenothiazines (Anti-psychotic)
Definition
Extrapyramidal, Neuroepileptic Malignant Syndrome (NMS), orthostatic HTN
Term
Phenothyazine Patient Teaching
Definition
baseline vitals, underlying disorders, report EPS or NMS, document daily dose on calendar, do stop abruptly
Term
Nonphenothiazine Prototype
Definition
Haloperidol (Haldol)
Term
Atypical Antipsychotic Prototype
(Drug of Choice for Schiz)
Definition
Clozapine (Clozaril)
Term
Clozapine Adverse Effects
Definition
Agranulocytosis, seizures, dizziness, fever, salivation, flu-like symptoms, tachycardia
Term
TCA Prototype - inhibits reuptake of serotonin and norepinephrine
Definition
Amitriptyline (Elavil), Imipramine (Trofanil)
Term
MAOI Prototype
Definition
Phenelzine (Nardil)
Term
MAOI S/E
Definition
Orthostatic Hypotension, insomnia, diarrhea, tyramine interaction
Term
SSRI Prototype
Selectively targets serotonin reuptake
Definition
Sertraline (Zoloft)
Term
SSRI S/E - greater safety
Definition
Sexual dysfunction, nausea, weight gain, anxiety, insomnia, SES
Term
Anticholinergic effects
Definition
dry mouth, blurred vision, urinary retention, constipation
Term
Sympathomimetic effects
Definition
increased heart rate and hypertension
Term
SS of Withdrawal from BZDs
Definition
Anxiety, tremors, respiratory depression, death
Term
Mood Stabilizer Prototype
Treatment for Bipolar Disorder
Definition
Eskalith (Lithium )
Term
Lithium toxicity
Definition
Vomiting, diarrhea, slurred speech, decreased coordination, muscle weakness, twitching
Term
MAOI/tyrmine interaction reversal
Definition
Calcium channel blockers
Term
Bile Acid Resins Administration
Definition
Give one hr before, 4-6 after other meals, mix w cool liquids,
Term
Lithium S/E (acts like sodium)
Definition
Dizziness, fatigue, s/t memory loss, increased urination, dry mouth, loss of appetite
Term
Lithium patient teaching
Definition
Do not avoid salt (reduces drug secretion), keep all lab visits, changes in diet or fluid intake can effect levels, avoid ETOH, OTC and herbals, drink plenty of fluids
Term
Atypical antipsychotic S/E
(Drug of choice for Schizophrenia)
Definition
Leukopenia and agranulocytis, osteoporosis, decreased libido, weight gain, do not cause EPS
Term
BZD Reversal drug (antagonist)
Definition
Flumazenil (Romazicon)
Term
TCA S/E
Definition
Orthostatic Hypotension, sedation, anticholinergic, seizures, sexual dysfuntion
Term
Antihyperlipidemic -
HMG-CoA reductase inhibitors
Definition
Statins - First line of treatment
Term
Class - Statins (think "liver")
Inhibits cholesterol production
Definition
Atorvastatin (Lipitor)
Term
Statins S/E
Definition
Rhabdomyolysis (break down of skeletal tissue), weakness and pain, abdominal cramps, elevated liver enzymes, interact with graprefruit
Term
Lab to check cholesterol
Definition
Lipid panel, LFT
Term
Statin Patient teaching
Definition
Take w/food, report muscle pain/weakness, avoid acohol and grapefruit
Term
Class - Bile Acid Resins(binds to bile acids and makes them too large to be absorbed)
Definition
Welchol, Questran
Term
Class Nicotinic Acid
Definition
Niacin - high dose of Vitamin B3
Term
Class - Fibric Acid Agents
(DO NOT GIVE WITH STATINS)
Definition
Lobid, Tricor
Term
Anticoagulants - Prevents Clot formation (II, VII, IX, X)
Definition
Coumadin, Heparin
prevent Venous thrombi from enlarging; do not lyse clots, are not blood thinners
Term
Coumadin (anti-coagulant)
Definition
inhibits sythesis of vitamin K dependent clotting factors
Term
Coumadin Labs
Definition
INR (2.0 - 3.5) and PT (1-2x pt baseline)
Term
Lithium serum range
Definition
0.6 - 1.5
Term
Bile Acid Resins S/E
Definition
No systemic effects, gas, NVD, vitamin absorption deficiency (take multivitamin)
Term
Coumadin Interactions
Definition
Many drugs, ETOH, antibiotics
Term
Coumadin S/E
Definition
bleeding
Term
Coumadin Pt teaching
Definition
Avoid alcohol, consume consisten amts of vitamin K, lab work
Term
Heparin (anticoagulant)mech of action
Definition
Low dose prevents conversion of prothrombin to thrombin; high dose prevent conversion of fibrinogen to fibrin
Term
Heparin administration
Definition
Sub Q or IV, quicker onset
Term
Heparin lab and therapeutic level
Definition
aPTT; 1.2 - 2.5 baselin aPTT; 20-45 seconds, monitor plateletts for HIT, wrong dose can be fatal for peds
Term
Heparinn antagonist
Definition
Protamine sulfate
Term
Heparin contraindication
Definition
Concurrent w/LMWH (fatal), thrombocytepnia
Term
Low Molecular Weight Heparin (LMWT)
Definition
Levenox, Fragmin
Term
Anticoagulants considerations
Definition
same time every day, assess for bleeding, transition from Heparin to Coumadin, both taken for 2-3 days, avoid ASA or NSAIDS
Term
Antiplatelet Classes
Definition
ASA (Aspirin)
ADP Receptor blockers (Plavix)
Term
Antiplatelet action (arterial circulation)
Definition
prevents platelette aggregation
Term
Antiplatelett S/E
Definition
bleeding, neutropenia, TTP (clots forming everywhere)
Term
Antiplatet considerations (dose 325 mg)
Definition
monitor CBC, Avoid ASA and NSAIDS
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