Term
| 4 elements of the Nuclear Receptor |
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Definition
| AF-1 Site, DNA Binding Domain, Hinge, Ligand Binding Domain |
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Term
| 3 Types of membrane receptors |
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Definition
| Tyrosine Kinase, G-Protein Linked, Ion Channels |
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Term
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Definition
Gamma: Master regulator in formation of fat cells
Alpha: Active during fasting, fatty acids are released into blood to liver for b-oxidation
Delta: expressed all the time, regulator of fatty acid oxidation. High expression = lean, resistant to obesity. |
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Term
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Definition
| F = dose absorbed / dose administered (IV) |
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Term
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Definition
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Term
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Definition
| Vd = amount in body/plasma concentrations |
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Term
| Therapeutic plasma concentration |
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Definition
dose/Vd
Vd = dose/plasma concenstration
If drug is high, Vd is low, if drug is low, Vd is high |
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Term
| Phase 1/Phase 2 Metabolism |
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Definition
Phase 1: Addition of OH/NH2
Phase 2: Conjugation of very reactive groups with highly water soluble substrate |
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Term
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Definition
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Term
| Clearance (as in, measuring how much of a drug is cleared by an organ). |
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Definition
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