Term
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Definition
| Inhibits DHFR (Antimetabolite), reversed by Leucovorin, |
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Term
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Definition
| Blocks the S-Phase, used in growing tumors. Interferes with conversion of deoxyuridylate to deoxythymidylate by the thymidylate synthase enzyme. |
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Term
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Definition
| Chain termination in DNA Synthesis. Competes with deoxycytidine |
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Term
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Definition
| Generates ROS's and thus: breaks DNA strands. DNA Intercollation generates strand breaks. |
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Term
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Definition
| Copper chelating agent that intercollates with DNA. Generates ROS's that break DNA strands. |
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Term
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Definition
| Antibiotics that prevent the resealing step caused by Topo II resulting in strand breaks. |
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Term
| Camptothecins (Topotecan) |
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Definition
| Binds to Topo1/DNA complex. Results in strand breaks |
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Term
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Definition
| Inhibit TopoII, results in strand breaks. |
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Term
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Definition
| Alkylating agent, transfers alkyl groups to guanine resulting in cross-linked DNA bases resulting in cell death or mutation |
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Term
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Definition
| Bind to B-Tubulin, interfere with microtubule formation (inhibits mitotic spindles). Cells arrest in Metaphase |
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Term
| Vinca Alkaloids (Vincristine, Vinblastine) |
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Definition
| Microtubules fail to polymerize |
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Term
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Definition
| Crosslinks G's causes strand breaks. |
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Term
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Definition
| Antiangiogenesis, it inhibits VEGF. |
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Term
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Definition
| Synthesis inhibitor for Norepinephrine |
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Term
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Definition
| Inhibits Norepinephrine storage |
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Term
| Tricyclic Antidepressants |
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Definition
| Inhibits the reuptake of Norepinephrine back into the neuron |
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Term
|
Definition
| Inhibits the release of Norepinephrine from the neuron |
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Term
|
Definition
| MAO inhibitor. MAO degrades Norepinephrine into DOPGAL, therefore, Norepinephrine goes up. |
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Term
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Definition
| Beta 1 agonist, increases contractility, heart rate, treats cardiac arrest |
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Term
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Definition
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Term
| Amphetamines (MDMA, Adderall) |
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Definition
| Displaces all Norepinephrine from the neuron.CNS stimulant, treats ADD, decreased appetite. |
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Term
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Definition
| Inhibits the uptake of Acetylcholine. |
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Term
|
Definition
| Inhibits the storage of Acetylcholine |
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Term
|
Definition
| Inhibits the release of Acetylcholine from the neuron |
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Term
|
Definition
| Irreversible Acetylcholinesterase inhibition |
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Term
|
Definition
| Muscarinic (M1,2,3 agonists) |
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Term
|
Definition
| Muscarinic (M1,2,3 antagonists), blocks receptors, can cause tachycardia, decreases GI, relaxation of bronchi, mydriasis and cycloplegia. |
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Term
| Latrotoxin (Black Widow Spider Venom) |
|
Definition
| Displaces Acetylcholine from the neuron |
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Term
| Methylphenidate (Ritalin) |
|
Definition
| Dopamine/Norepinephrine reptake inhibitor |
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Term
|
Definition
| A1 agonist, causes vasoconstriction, can controls bleeding, decongestant, mydriasis, and hypotensive emergencies. |
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Term
|
Definition
| A2 agonist, Lower Norepinephrine release, causes vasodilation |
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Term
|
Definition
| B2 Agonist, Dilates bronchi, relieves asthma |
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Term
|
Definition
| Norepinephrine displacer, stimulates the release of endogenous norepinephrine |
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Term
|
Definition
| Mixed direct/indirect displacer of Norepinephrine |
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Term
|
Definition
| A1,2 antagonist (reversible) |
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Term
|
Definition
| A1,2/B1 Blocker, treats congestive heart failure |
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Term
|
Definition
| A1,2/B1,2 Blocker, treats hypertensive emergencies. |
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Term
|
Definition
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Term
|
Definition
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Term
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Definition
| Nicotinic (m) antagonist, blocks Ach on skeletal muscles via competition, Muscles will stop after 70% of receptors are blocked. Fast muscles are more sensitive than slow. |
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Term
|
Definition
| Combats irreversible Acetylcholinesterase inhibition (as caused by nerve gas) |
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Term
|
Definition
| Irreversible blocker of A1,2 |
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Term
|
Definition
| A2 antagonist, increases arterial blood to certain tissue |
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Term
|
Definition
| A-1 Antagonist (reduces vasoconstriction and peripheral resistance, treats hypertension) |
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Term
|
Definition
| A-1 Antagonist (reduces vasoconstriction and peripheral resistance, treats hypertension) |
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Term
|
Definition
| B1 Antagonist. Lower heart rate and contractility, lower renin, treats hypertension and angina |
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Term
|
Definition
| B1 Antagonist. Lower heart rate and contractility, lower renin, treats hypertension and angina |
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Term
|
Definition
| B1 Antagonist. Lower heart rate and contractility, lower renin, treats hypertension and angina |
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Term
|
Definition
| Reversible, Short acting/ temporary inactivation of Acetylcholinesterase. |
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Term
|
Definition
| Reversible Acetylcholinesterase inhibitor used to treat myasthenia gravis (Muscle weakness caused by lower Acetylcholine), glaucoma, paralysis induction. |
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Term
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Definition
| Blocks muscarinic acetylcholine receptors in lungs. Used to treat asthma and open bronchi. |
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Term
|
Definition
| Blocks Acetylcholine (via depolarization). Is short-acting (5 minutes), receptors are inactivated via overstimulation. It is used for relaxation during surgery, mechanical breathing (intubation) |
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