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| use of pharmacokinetic calculations |
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Definition
| determine and adjust drug dosages to achieve desired therapeutic effect |
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units of infusion rate
units of rate of elimination |
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| equation for rate of elimination |
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Definition
Rate of elimination=Cl x Cp
Cp=Dose/Vd |
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| Cl=rate of elimination/Cp |
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| Infusion rate (dose) = Cl x Css |
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| Css is directly proportional to |
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| continuous IV infusion equation |
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| Css= rate of infusion (dose rate)/ Cl |
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| 1/fraction lost in one dosing interval |
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| peak steady state equation |
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| peak stead state concentration=peak concentration (initial) x accumulation factor |
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| peak plasma level equation |
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| peak plasma level = initial dose/fraction lost |
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| when dosing interval equals the half life the accumulation ratio is always |
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| maintainence dose equation |
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MD= Cl x Css
Oral: MD= Cl x Css/ F |
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LD= Vd x Css
Oral LD = Vd X Css / F |
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| Rule of thumb when to check plasma drug concentration? |
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Definition
| before next dose after 2 half lives |
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