inhibit ACE between angiotensin I and II

lower bp

-pril

all except captopril and lisinopril are prodrugs and have long t1/2

rampiril may help reduce risk of diabetes

cough, increased bradykinin, angioedema, ARF (increased serum creatinine, do not use in patients with unilateral renal artery stenosis), hyperkalemia (do not mix with K sparing)

do NOT use in pregnancy

AT1 = increase in bp, increase in cell proliferation

AT2 = decrease in cell proliferation

angiotensin II receptor antagonists

reduce bp, but do not increase bradykinin levels

-sartan

Angiotension II receptor antagonists and HCTZ together in one drug

ACE inhibitors and HCTZ combined into one drug

ACE and calcium channel blockers