Term
| phosphodiesterase inhibitors (PDE-Is) |
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Definition
| inhibits PDE and breakdown of cAMP and cGMP, PDE-Is are location-specific, unselective, eg xanthine |
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Term
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Definition
unselective PDE-I and adenosine-1 receptor blocker (low dose, increase kidney perfusion)
theophylline and aminophylline are asthma drugs, reliever (iv) or controller (po) drugs |
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Term
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Definition
1A2 induction
(smoke induces 1A2 [cigs and bbq])
easy to move into toxic range (small therapeutic index) |
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Term
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Definition
easily saturable, shifts to zero order kinetics
CNS activation and catecholamine release: tachyarrhythmia, N&V, etc |
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Term
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Definition
selective
-rinone
inotropic agents in severe cardiac failure |
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Term
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Definition
selective
-milast
used for COPD, reduce inflammation |
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Term
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Definition
block the degradative action of PDE type 5 on cGMP; vasodilation
-afil
side effects due to vasodilation; Sildenafil also inhibits PDE6 in the retina, which is thought to be responsible for the vision changes
mostly 3A4 metabolized
sildenafil and vardenafil = short
tadalafil (cave in CAD)= long
cave nitrates |
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