Term
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Definition
| A response to tissue injury and infection |
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Term
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Definition
| Caused by microorganisms and results in inflammation, but not all inflammations are caused by this |
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Term
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Definition
| Chemical mediators which have many effects: vasodilation, relaxation of smooth muscle, increased capillary permeability, and sensitization of nerve cells to pain |
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Term
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Definition
| The enzyme responsible for converting arachidonic acid into prostaglandins and their products |
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Term
| Nonsteroidal Antiinflammatory Drugs (NSAIDs) |
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Definition
| A class of analgesic medication that reduces pain, fever and inflammation. Since most episodes of back pain involve inflammation, NSAIDs such as ibuprofen and naproxen are often an effective treatment option. |
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Term
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Definition
| Block only COX-2. These drugs leave protection for the stomach lining intact, but still deliver relief for pain and inflammation. |
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Term
| Disease-modifying antirheumatic drugs (DMARDs) |
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Definition
| Include immunosuppressive agents, immunodulators, and antimalarials. These help alleviate the symptoms of rheumatoid arthritis for the 2 million people in the US affected by the disorder. |
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Term
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Definition
| Used to treat refractory rheumatoid arthritis (arthritis that does not respond to anti-inflammatory drugs). |
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Term
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Definition
| Treat moderate to severe rheumatoid arthritis by disrupting the inflammatory process and delaying disease progression. |
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Term
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Definition
| An inflammatory condition that attacks joints, tendons, and other tissues. |
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Term
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Definition
| Increase the rate of uric acid excretion by inhibiting its reabsorption. |
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Term
Drug class: analgesic: anti-inflammatory drug
Therapeutic effects/uses: Reduce pain and inflammatory symptoms, decrease body temperature, inhibit platelet aggregation
Side effects: anorexia, nausea, vomiting, diarrhea, dizziness, confusion, hearing loss, heartburn, rash, abdominal pain, drowsiness
Adverse reactions: Tinnitis, urticarial, ulceration, GI bleeding |
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Definition
Prototype Drug: Aspirin
Drug class:
Therapeutic effects/uses:
Side effects:
Adverse reactions: |
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Term
Drug class: NSAID, propionic acid derivative
Therapeutic effects/uses: reduce inflammatory process, relieve pain, anti-inflammatory effect for arthritic conditions, reduce fever
Side effects: anorexia, nausea, vomiting, diarrhea, edema, rash, purpura, tinnitus, fatigue, dizziness, lightheadedness, anxiety, confusion, fluid retention
Adverse reactions: GI bleeding |
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Definition
Prototype Drug: Ibuprofen
Drug class:
Therapeutic effects/uses:
Side effects:
Adverse reactions: |
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Term
Drug class: NSAID Cox-2 inhibitor
Trade name: Celebrex
Therapeutic effects/uses: treat osteoarthritis and rheumatoid arthritis, to relieve dysmenorrhea
Side effects: headache, dizziness, sinusitis, nausea, flatulence, diarrhea, rash
Adverse reactions: peripheral edema |
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Definition
Prototype drug: Celecoxib
Drug class:
Trade name:
Therapeutic effects/uses:
Side effects:
Adverse reactions: |
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Term
Drug class: uric acid biosynthesis inhibitor
Trade name: Zyloprim, Aloprim, Apo-Allopurinol
Therapeutic effects/uses: treat gout and hyperuricemia, prevent urate calculi
Side effects: anorexia, nausea, vomiting, diarrhea, stomatitis, dizziness, headache, rash, edema, erectile dysfunction
Adverse reactions: Cataracts, retinopathy, bradycardia, depression |
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Definition
Prototype drug: Allopurinol
Drug class:
Trade name:
Therapeutic effects/uses:
Side effects:
Adverse reactions: |
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Term
Erythema
Edema
Heat
Pain
Loss of function |
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Definition
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Term
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Definition
| Triggers pain and inflammation |
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