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Pharmacology Vocabulary Ch 19
Pharmacology Vocabulary Ch 19
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Pharmacology
Undergraduate 2
02/10/2016

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Term
Cholinergic agonist OR parasympathomimetics
Definition
Drugs that stimulate the parasympathetic nervous system
Term
Acetylcholine (ACh)
Definition
the neurotransmitter located at the ganglions and the parasympathetic terminal nerve endings. Innervates cholinergic receptors in organs, tissues, and glands.
Term
Muscarinic receptors
Definition
cholinergic receptor which stimulates smooth muscle and slows heart rate
Term
Nicotinic receptors
Definition
cholinergic receptor which affects the skeletal muscles
Term
Direct-acting cholinergic agonists
Definition
act on receptors to activate a tissue response
Term
Cholinesterase (ChE)
Definition
an enzyme that is inhibited by indirect-acting cholinergic agonists
Term
Anticholinesterase (AChE)
Definition
Drugs that inhibit cholinesterase
Term
Miosis
Definition
Constriction of the pupils of the eyes.
Term
Direct-acting cholinergic agonists
Definition
Drugs that are selective to the muscarinic receptors but are nonspecific because the muscarinic receptors are located in the GI tract, glands, and heart.
Term
Indirect-acting cholinergic agonists
Definition
inhibit or inactivate the enzyme cholinesterase, permitting ACh to accumulate at the receptor sites.
Term
Anticholinergics OR Parasympatholytics OR Cholinergic blocking agents
Definition
Drugs that inhibit the actions of ACh by occupying the ACh receptors
Term
Cholinergic agonists, parasympathomimetics, cholinomimetics, cholinergic stimulants
Definition
Drugs that stimulate the parasympathetic nervous system are called ____(4 names) because the mimic the parasympathetic neurotransmitter ACh.
Term
Muscarinic receptors (stimulate smooth muscle and heart rate)
Nicotinic receptors (affect skeletal muscles)
Definition
2 types of cholinergic receptors
Term
Direct-acting cholinergic agonists
Definition
Act on the receptors to activate a tissue response.
Term
Indirect-acting cholinergic agonists
Definition
Inhibit the action of the enzyme cholinesterase (ChE)
Term
Extravasation
Definition
The leaking of fluid from a blood vessel into the surrounding tissues, as in the case of an infiltrated intravenous infusion.
Term
Lipophilicity
Definition
The chemical attraction of a substance to lipid or fat molecules
Term
Inhibitory
Definition
Are alpha2 receptors inhibitory or stimulatory
Term
Beta-1 adrenergic receptors
Definition
Receptors that are located primarily in the heart
Term
Beta-2 adrenergic receptors
Definition
receptors that are located primarily on the smooth muscles of the bronchioles and blood vessels
Term
Pheochromocytoma
Definition
A tumor that forms on the adrenal gland on top of the kidney and secretes norepinephrine, thus causing SNS stimulation. Alpha-blockers may prevent hypertension in patients who have this condition.
Term
Tissue necrosis
Definition
When drugs extravasate, or leak out of the blood vessel into the surround tissue, they cause vasoconstriction and ultimately _____________.
Term
Phentolamine
Definition
_____ can reverse the potent vasoconstriction and restore blood flow to the ischemic tissue, preventing necrosis.
Term
Diazepam
Definition
Used for control of seizures
Term
False (Drugs with intrinsic sympathomimetic activity block beta-adrenergic receptors, but also partially stimulate them)
Definition
True or false: Drugs with intrinsic sympathomimetic activity stimulate beta-adrenergic receptors.
Term
Beta-1 receptors on the surface of the heart
Definition
Cardioselective beta1-blockers block which receptors and where are they located?
Term
Glycogenolysis
Definition
Production of glucose from glycogen -- catecholamines promote this.
Term
Beta blockers
Definition
Which blockers are considered to be cardioselective?
Term
False (beta-blockers protect the heart from being stimulated by catecholamines)
Definition
True or false: alpha-blockers protect the heart from being stimulated by catecholamines.
Term
True
Definition
True or false: Because of their lipophilicity, some beta-blockers can easily gain entry into the central nervous system and are used to treat migraine headaches.
Term
True
Definition
True or false: The patient's prescriber should be notified if the patient shows an increase of 2+ pounds in a 24 hour period or 5+ pounds within 1 week.
Term
Phentolamine
Definition
The nurse discovers that the intravenous infusion of a patient who has been receiving an intravenous vasopressor has infiltrated. The nurse will expect which drug to be used to reverse the effects of the vasopressor in the infiltrated area? A. Phentolamine B. prazosin (Minipress) C. ergotamine D. metoprolol (Lopressor)
Term
A. vasodilation, B. decreased blood pressure, and D. Constriction of the pupil
Definition
Adrenergic blockade at the alpha-adrenergic receptors leads to which of the following effects? A. Vasodilation B. Decreased blood pressure C. Increased blood pressure D. Constriction of the pupil E. Tachycardia
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