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Pharmacology Unit 2
Analgesics & Anti-inflammatory Agents
34
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Undergraduate 2
12/09/2008

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Term
Pain & Pain tolerance
Definition
Pain is what ever the pt says it is.
Pain tolerance is the amount of pain that a person can withstand before breaking down emotionally and/or physically.
Term
Factors which affect the individual's response to pain
Definition
religion, age, culture, or environment
Term
Factors included in assessment of pain
-what are the assessment??
-what is included in a pain history?
Definition
assessment-Pain scale, location, duration,& intensity.
history-finding out what has helped before
Term
Schedule I & II drugs
Definition
Schedule I: high potential for abuse
-no accepted medical use in US
Schedule II:high potential for abuse
-opiate analgesics
Term
Schedule III & IV drugs
Definition
Schedule III:lower potential for abuse that schedule II-tylenol with codeine
Schedule IV: lower potential for abuse than schedule III-Librium, Valium
Term
Schedule V drugs
Definition
Lowest potential for abuse
-Usually antidiarrheal & antitussive
-Lomotil
-Robitussin A-C
Term
Analgesics
Definition
relieve pain without loss of consciousness
Term
Actions of narcotic analgesics
Definition
Bind to opiate receptors in the CNS
-this inhibits transmission of pain impulse and alters pain perception
-also produce euphoria
Some are opioid agonists
Some are agonist-antagonists
Term
What is an agonist?
Definition
combines to create action
resist/oppose action
Term
S/E of opioids
Definition
N/V, tolerance, constipation, respiratory depression, dependence
Term
S/E when opioids are discontinued
Definition
sweating, restlessness, diarrhea
Term
S/S of overdose
Definition
-respirations under 12/minute
-pin point pupils
-coma
Term
Drugs that can be used to reverse overdose effects
& how does it work?
Definition
Narcan 9R
antagonists of opioids
Term
Effects of morphine sulfate (MS)
Definition
oral, subc, IV, IM, rectal, sublingual, "mother" of all narcotics, MS, 5-20 mg dose q 4 hrs, 10-60 min onset, longer
duration of action than Demerol
CAN BE USED IN CANCER PAIN
Term
Effect of meperidine (Demerol)
Definition
Oral, Subc, IV, IM, 50-100 mg q 3-4hrs, 10-45 min onset, shorter duration of action than MS
CAUSES HALLUCINATIONS
Term
Some narcotic analgesics
Definition
Hydrocodone + acetaminophone
Fentanyl (Duragesic)
Oxycodone + ASA (Percodan)
Term
How narcotics work
Definition
in the CNS and affect the nociceptors (nerve endings) and the neurotransmitter pathways of pain transmission
Term
How Acetaminophen, ASA, & NSAIDs work
Definition
in the periphery and interfere with prostaglandins
Term
NI associated with narcotic administration
Definition
double lock, sign out, use non-drug interventions first, assess pain, give meds before pain get severe, don't under treat pain
Term
NI associated with salicylates
Definition
Peripherally acting, interfere with the synthesis of proglandins
Term
prostaglandin
Definition
a group of naturally occurring, chemically related, long-chain hydroxy fatty acids that stimulate contractility of the uterine and other smooth muscle tissues and have the ability to lower bp and to affect the action of certain hormones
Term
acetylsalicylic acid
(aspirin, ASA)
4 things it does & doses for each
Definition
analgesic-650 mg
anti-inflammatory- 325 mg
antipyretic- 650 mg
antiplatelet- 81 mg
Term
NI for ASA
Definition
contraindicated if:
on anticoagulants-bleeding
if gastic ulcer-bleeding
pregnancy-hemorrhaging/crosses placental barrier
Term
What does it mean when the label says the ASA is buffered?
Definition
it has an antacid in it
Term
Signs of salicylate poisoning
Definition
tinnitus (ringing in ears)
increased temp
nausea/vomiting
lethargy/excitability
hyperventilation
Term
Uses, advantages, & major disadvantages of acetamenophen (tylenol)
Definition
nonopioid analgesic
antipyretic
available as a liquid
HEPATOTOXITY (over 4 gm/day)
NEPHROTOXICTY
Term
Non-narcotic analgesics
Definition
buprenophine HCl (buprenex)
butophanol tartate (stadol)
Pentazocine HCl (Talwin)
Ibuprofen (motrin)
Naproxin (aleve)
Term
Nonsteroidal anti-inflammatory agents
Definition
modify inflammation response
-inhibit prostagladin synthesis
-includes aspirin, as well as Motrin, aleve, Indomethancin, oxaprozin (daypro), ketoralac (Toradol)-only drug of this kind that can be given as a IM or IV
Term
COX-2 inhibitors
Advantages & disadvantages
Definition
a:less GI bleeding than other NSAIDs, once a day or BID dosing
d:can't use if allergic, expensive
Term
Gout
Definition
caused by uric acid crystals
desposit in joints and subq tissue
treat ASAP when acute attacks occur
treat acute attacks with colchicine(IV or oral)
Term
Colchicine
Action
Definition
it prevent migration of graulocytes to inflammed area so no lactic acid is released
Term
Colchicine
adverse effects
Definition
N/V
diarrhea, GI bleeding, neuritis (inflammation of the nerve endings),myopathy (muscle wasting away), alpoecia (hair loss), bone marrow depression
Term
alternative treatments for gout
Definition
NSAIDs
& two other types of drugs besides colchicine
Term
uricosurics
adverse effects & examples
Definition
AE:kidney stones can develop
EX: probenecid (Benemid) & sulfinpyrazone (Anturane)
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