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Pharmacology TWU
TEST #1
81
Health Care
Undergraduate 3
09/10/2007

Additional Health Care Flashcards

 


 

Cards

Term
Where are alpha adrenergic receptors located and what happens when they're agonized/antagonized?
Definition
LOCATIONS: smooth muscles & sphincters, ie blood vessels, GI tract, salivary glands, urinary sphincter, radial muscle of eye

AGONIZED/ACTIVATED: SYMPATHETIC RESPONSE (fight or flight); contrax of smooth muscle/sphincters -> vasoconstriction & urinary & bowel retention & mydriasis (far vision focus); dry mouth; glycogen breakdown

ANTAGONIZED/BLOCKED: PARASYMPATHETIC (RELAXATION): vasodilation, defecation/urination, salivation, near vision focus
Term
Where are beta1 adrenergic receptors & what happens when antagonized/agonized?
Definition
LOCATION: ALL IN HEART...remember, 1 heart, beta 1 receptors

AGONIST/ACTIVATION: SYMPATHETIC: heart beats faster & harder

ANTAGONIST/BLOCKER: PARASYMPATHETIC: slows the heart down
Term
Where are beta2 adrenergic receptors & what happens when they are antagonized/agonized?
Definition
LOCATION: HEART,SMOOTH MUSCLE OF GI TRACT & BLADDER, KIDNEY, LIVER -->Beta 2 receptors less selective than Beta1 =more side effects

AGONIZED/ACTIVATED: SYMPATHETIC: inc. HR; BRONCHODILATION (remember 2 lungs, beta 2 receptors); dec. defecation & urination; tells kidney to release renin --> VASOCONSTRICTION; glycogen breakdown

ANTAGONIZED/BLOCKED: dec. heart rate & force; BRONCHOCONSTRICTION; defacation/urination; glycogen synthesis (always goes along w/increased digestive fxn)
Term
Autonomic terminology that denotes
parasympathetic activity
Definition
cholinergic
parasympathomimetic (-mimetic = mimics/acts like)
sympatholytic (-lytic = antagonizes/blocks/opposite)
nicotinic/muscarinic (cholinergic receptors)
Term
Autonomic terms which denote sympathetic activity (fight or flight)
Definition
adrenergic sympathomimetic (-mimetic=mimics/acts like) parasympatholytic (-lytic = opposite) anticholinergic antimuscarinic
Term
BETHANECHOL (URECHOLINE)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
CHOLINERGIC

indications: URINARY RETENTION, GERD(gastric reflux)
weird side effects:cholinergic effects (parasympathetic), dec HR &
BP, diarrhea, BRONSHOCONSTRICTION

contra indications: asthma, PUD, phys obstruction of urinary tract

DO NOT GIVE WITH MEALS!!!! 1 HR BEFORE OR 2 HR AFTER


-dec HR, bronchoconstriction, sweating, erection, vasodialtion, activation of bladder & diestive tract
Term
ATROPINE

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
Muscarinic antagonist (SYMPATHETIC)

indications: BRADYCARDIA, IBS/DYSENTERY, eye exams/eye surgery, drying of mucus membranes before surgery

weird side effects:xerostomia, blurred vision, INC. IOP (intra-ocular pressure), urinary & bowel retention,tachycardia
contra indications
IMPORTANT FACTS
Term
NMJ Blockers
Definition
d-Tubocurarine
succinylcholine
Term
cholinesterase inhibitors
Definition
NEOSTIGMINE
PHYSOSTIGMINE
Term
Atropine

Indications
Contraindications
Side Effects
Nursing Implications
Definition
INDICATIONS
-bradycardia: inc. HR; vasodilation w/high doses; blox Ach at SA & AV nodes
-preoperatively: dries secretions of mucus membranes, stomach, salivary glands, sweat glands, lungs
-IBS/dysentery:dec. motility of GI tract
-eye exams/eye surgery: causes pupil dilation

CONTRAINDICATIONS
PUD, asthma, glaucoma, intestinal atony, urinary obstruxn, tachycardia

SIDE EFFECTS
-dry mouth (xerostomia)
-blurred vision, photophobia
-inc. IOP (intra ocular pressure)
-urinary retention
-constipation
-inability to sweat
-tachycardia

NURSING IMPLICATIONS
-provide relief for dry mouth 7 swallowing difficulty
-use eye protex for light
-monitor HR
-avoid extreme high temps
Term
oxybutynin (Ditropan)
tolterodine (Detrol)
trospium chloride (Sanctura)
solifenacin succinate (Vesicare)

Routes of Administration
Mechanism of Action
Indications
Contraindications
Side Effects
Nursing Implications
Definition
Route of Administration: Oral, patch

Mech o/action: Anticholinergic

INDICATIONS
-OAB (over active bladder)

CONTRAINDICATIONS
-urinary retention
-gastric retention
-uncontrolled narrow-angle glaucoma

SIDE EFFECTS
-dry mouth
-constipation
-dry eyes, blurred vision(dilated pupils)
-drowsiness

IMPLICATIONS
-intervene for dry mouth
-assess urinary patterns regularly
-watch out for overheating
-sunglasses
Term
SCOPOLOMINE (Transderm-Scop)

Routes of Administration
Mechanism of Action
Indications
Contraindications
Side Effects
Nursing Implications
Definition
Routes of Admin: behind the ear patch

Mech of axn: anticholinergic

Indications
-IBS (irritable bowel syndrome)
-motion sickness

Contraindications:
-elderly
-alcohol
-glaucoma

Side Effects
-drowsiness
dry mouth
dilated pupils
blurred vision
flushing
diff urinating
hallucinations
confusion

OD
delirium, delusions, paralysis, stupor, death

antidote: physostigmine
Term
Name three differences between the catecholamine and noncatecholemine sympathomimetic agents (adrenergic agonists)
Definition
catecholamines vs. noncatecholamines

1. catecholamines cannot be used orally/ non's CAN
2. catecholamines have short duration o/action /non's have longer half-lives
3. catecholamines cannot cross BBB (too poolar)/ non's can
Term
Which adrenergic receptors are agonized (activated) by epinephrine?
Definition
alpha 1
alpha 2
beta 1
beta 2
Term
Which adrenergic receptors are agonized (activated) by norepinephrine?
Definition
alpha 1
alpha 2
beta 1
Term
Which adrenergic receptors are agonized (activated) by isoproterenol?
Definition
Beta 1
beta 2
Term
Which adrenergic receptors are agonized (activated) by dopamine?
Definition
alpha 1
beta 1
dopamine
Term
Which adrenergic receptors are agonized (activated) by dobutamine?
Definition
beta 1 only
Term
Name tHREE adrenergic agonists which activate/agonize alpha receptors and:

INDICATIONS
SIDE EFFECTS
CONTRAINDICATIONS
NURSING IMPLICATIONS
Definition
EPINEPHRINE, NOREPINEPHRINE, DOPAMINE

INDICATIONS
-Used w/ local anesthesia to delay absorption (vasoconstriction)
--hypotension
-hemostasis

SIDE EFFECTS
-inc. BP (hypertension)
-bradycardia
-necrosis o/nearby tissues if IV line extravasated

CONTRAINDICATIONS
-hypertension
-bradycardia

NURSING IMPLICATIONS
-check position of IV line regularly
-check HR & BP regularly
Term
Drug Class: Anti-Epileptics (AED's)
drugs and common side effects
Definition
phenytoin (Dilantin)
fosphenytoin (Cerebyx)
carbamazepine (Tegretol)
valproic acid (Depakote, Depakene)
phenobarbitol (Luminal)
gabapentin (Neurontin)
magnesium sulfate

Common Side Effects:
GI upsets (N, V, dyspepsia, take with food)
Sleepiness, dizziness, lightheadedness, HA, fatigue (usually goes away with time)
Weight Gain
Term
PHENYTOIN (Dilantin)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
anti-epileptic: partial & tonic-clonic seizures
DOESN'T TREAT ABSENCE SEIZURES

Weird side effects: gingival hyperplasia (gum overgrowth); hirsutism; rash (Stevens-Johnson syndrome, fatal)

Contraindications: the pill, warfarin, steroids, all CNS depressants, pregnancy

NARROW THERAPEUTIC RANGE (10 - 20 MCG/ML)
toxicity: diplopia, nystagmus, slurring, ↓ BP, ↓ RR
DOESN'T TREAT ABSENCE SEIZURES
NO IV ADMIN, PO ONLY
Term
FOSPHENYTOIN (Cerebyx)


indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
anti-epileptic: partial & tonic-clonic seizures
DOESN'T TREAT ABSENCE SEIZURES
Weird side effects: gingival hyperplasia (gum overgrowth); hirsutism; rash (Stevens-Johnson syndrome, fatal)

Contraindications: the pill, warfarin, steroids, all CNS depressants, pregnancy

NARROW THERAPEUTIC RANGE (10 - 20 MCG/ML)
toxicity: diplopia, nystagmus, slurring, ↓ BP, ↓ RR
DOESN'T TREAT ABSENCE SEIZURES
IV ADMINISTRATION
Term
CARBAMAZEPINE (Tegretol)


indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
anti-epileptic: partial & tonic-clonic seizures
DRUG OF CHOICE FOR PARTIALS

weird side effects: bone marrow suppression; CHF; SOMETIMES STOPS WORKING AFTER A FEW WEEKS

contraindications: the pill, warfarin, phenytoin, phenobarb, pregnancy grapefruit juice

IMPORTANT FACTS: nursing implications: monitor CBCs, RBC, WBC, platelets BEFORE & AFTER therapy; monitor I & O,
Term
VALPROIC ACID (Depakote, Depakene)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
ANTI-EPILEPTIC: ALL SEIZURES, PLUS MIGRAINES

weird side effects: HEPATOTOXICITY; BLOOD DYSCRASIAS; hirsutism, rash hair loss, tremors; PANCREATITIS

contraindications: TERATOGENIC, liver disease, phenobarb., phenytoin

important facts: monitor LFT & CBC
Term
PHENOBARBITOL (Luminal)
Definition
ANTI-EPILEPTIC
effective, cheap, 1Xday
sedating, depression, learning impairments
Term
GABAPENTIN (Neurontin)


indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
ANTI-EPILEPTIC (AED): PARTIAL SEIZURES; ADJUNCT TO OTHER AED'S; NEUROPATHIC PAIN

weird side effects: nystagmus, confusion, peripheral edema

contraindications: RENAL DISEASE, ANTACIDS
Term
MAGNESIUM SULFATE

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
ANTIEPILEPTIC (AED): DRUG OF CHOICE FOR PREGNANCY SEIZURES FROM ECLAMPSIA; magnesium deficiency

weird side effects: dec. reflexes, dec. muscle tone, heart block, vital sign changes

toxicity: dec. BP, dec. RR, dec HR, dec. reflexes, flaccid paralysis, CNS DEPRESSION
Term
CAUSES & SIGNS OF MG DEFICIENCY
Definition
Causes: alcoholism, diarrhea, V, DKA (diabetic ketoacidosis), dehydration, diuretics, sepsis, burns, debrided wounds

Signs: 3T'S (TREMOR, TETANY, TWITCHING); hyperactive DTRs; confusion, seizures, dysrhythmias, Chvostek's sign (facial spasm when tap on CN VII), Trousseau's sign (hand spasm when BP cuff inflated above systolic BP)
Term
Drug class: Central-Acting Muscle Relaxants

list drugs & common side effects
Definition
baclofen (Lioresal)
diazepam (Valium)
dantrolene (Dantrium)

given for multiple sclerosis, cerebral palsy, spinal injury

common side effects: drowsiness, dizziness, fatigue, weakness, GI upset
Term
BACLOFEN (Lioresal)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
indications: MS, CP, spinal injury

weird side effects: urinary retention

contraindications: alcohol & CNS depressants

nursing implications: assess spasms, pain, ROM, rigidity
Term
DANTROLENE (Dantrium)

indications
weird side effects
Definition
indications: MS, CP, spinal injury, MALIGNANT HYPERTHERMIA

weird side effects: HEPATOTOXICITY
Term
effects of pain
Definition
destructive cascade of stress hormones

weakened immune system

inc. HR
inc. BP
Term
Drug class: OPIOIDS

list drugs & common side effects
Definition
MORPHINE
FENTANYL (duragesic, sublimaze, fentanyl oralit, actiq)
MEPERIDINE (DEMEROL)
CODEINE
OXYCODONE ( oxycontin)
HYDROCODONE (vicodin, lortab)

side effects: drowsiness, RESPIRATORY DEPRESSION, CONSTIPATION, N, V, DECREASED BP, HA, miosis, URINARY RETENTION, cough suppression, TOLERANCE, addiction
Term
Drug class: Opioid antagonist

list drugs & common facts & side effects
Definition
NALOXONE (Narcan)
NALMEFENE (Revex)

_parenteral adminin
_reverses all opioid effects ( including analgesia)
_given for OD, toxicity (resp <8 bpm; CNS depression; unresponsive pinpoint pupils, coma)
_triggers acute abstinence syndrome (increasing vitals, seizures, twitching, cardiac arrest)
Term
MORPHINE

indications
weird side effects
contra indications
IMPORTANT FACTS"
Definition
SEVERE PAIN

weird side effects: BILIARY COLIC, INCREASED INTRACRANIAL PRESSURE
contraindications: asthma, pulmonary disease, pregnancy, L&D, HEAD INJURY, infants, elderly, gallbladder disease

keep opioid antagonist at hand

TOXIC TRIAD: COMA, RESP DEPRESSION, MIOSIS(pinned pupils)
normal dose 10 - 30 mg q 4h po, 2 - 10 mg q 4h IV in 5cc H2O
Term
FENTANYL (Sublimaze, Duragesic, Oralet, Actiq)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
indications: severe, CHRONIC pain

side effects same as all opioids
contra indications: children under 12, weight under 110

IMPORTANT FACTS
Admin: transdermal, parenteral, lozenge (oralet, conscious sedation, DANGEROUS), lollipop (breakthrough pain in opioid tolereant pt)
Term
MEPERIDINE (Demerol)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
indications: severe pain, SHORT TERM (24 - 48 hr), OB pain

weird side effects: metabolite buildup (dysphoria, irritability, tremors, seizures)
contra indications: depression, anitdepressants, kidney/liver disease
admin PARENTERAL only (not oral)
Term
CODEINE

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
indications: MILD TO MODERATE pain, coughing, diarrhea
weird side effects: watch for allergy (hives), SOB, dyspnea

IMPORTANT FACTS:
10% of people lack enzyme to make codeine active…doesn't work for them
Term
OXYCODONE (oycontin)

indications
IMPORTANT FACTS
Definition
indications: SEVERE PAIN, ESP CANCER
LONG ACTING, controlled release over 12 hours
HIGH ABUSE POTENTIAL
HIGH OD POTENTIAL IF NOT TAKEN WHOLE
Term
HYDROCODONE (vicodin, lortab)

indications
Definition
indications: MILD to moderate pain; COUGHING
WATCH FOR ALLERGY
Term
How to manage an opioid OD
Definition
*emesis or gastric lavage
*est. patent airway, ventilator
*NALOXONE (Narcan)
Term
ASA (aspirin)

indications:
weird side effects
contra indications
IMPORTANT FACTS
Definition
indications: fever, inflammation, mild pain, reduction of coagulation for MI, TIA, STROKE, ANGINA

weird side effects: GI bleeding/irritation; RENAL IMPAIRMENT; BLEEDING, bruising

contra indications: bleeding disorders, anticoagulants; steroids; ibuprofen; CHILDREN (REYE'S SYNDROME)

IMPORTANT FACTS
OD=1ST SIGN IS TINNITUS, sweating, HA, dizziness, respiratory depression, hyperthermia, dehydration, electrolyte imbalance
Term
ACETAMINOPHEN (tylenol)

indications:
weird side effects
contra indications
IMPORTANT FACTS
Definition
indications: fever, mild pain, those allergic to ASA, children, those w/PUD

weird side effects: HEPATOTOXICITY W/OD;

contra indications: alcohol, coumadin ( it increases the anti-coagulant effect)

IMPORTANT FACTS

NO ANTI-INFLAMMATORY OR PLATELET ANTI-COAGULANT PROPERTIES


ACETYLCYSTEINE (mucomyst) w/in 8-24 hours for OD
Term
IBUPROFEN (advil, motrin) and other NSAIDS (naproxen, toradol, ketoprofen, oxaprozin)

indications:
contra indications
IMPORTANT FACTS
Definition
indications: mild pain, fever, INFLAMMATION, DYSMENORRHEA

contra indications: liver/kidney disease; allergy to ASA, alcohol, ACE inhibitors

IMPORTANT FACTS
monitor for bleeding time increase and fluid volume excess
Term
CELECOXIB (celebrex)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
indications: anti-inflammatory, acute pain

weird side effects: renal toxicity ( edema, hypertension), blood clotting (prothrombic)

contra indications: renal disease; sulfa allergy; pregnancy; heart disease

IMPORTANT FACTS
dec ACE inhibitors effect
dec Lasix effect
INCREASE LITHIUM LEVELS
Term
ERGOT ALKALOIDS (ergotamine tartrate)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
indications: DRUG OF CHOICE FOR MIGRAINE

weird side effects: N, CARDIAC PROBLEMS; PARESTHESIAS

contra indications: pregnancy, sepsis, CAD, PVD, triptans, liver disease, fever

TOXICITY: ischemia leading to gangrene

admin: oral, SL, rectal, inhaled
Term
SUMATRIPTAN (imitrex)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
indications: Migraine rescue

weird side effects: CHEST PAIN (50%OF PEOPLE); MI, dysrhythmias, STROKE, bad taste in mouth, drowsiness

contra indications: pregnancy, PRIOR MI HTN CAD

Admin: po, sc, nasal spray
Term
FLUMAZENIL (ROMAZECON)
Definition
Given for Benzo OD
counteracts drowsiness & confusion, but NOT RESP DEPRESSION
Term
Drug Class: BENZODIAZEPINES

list drugs
indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
ALPRAZOLAM (XANAX); DIAZEPAM (VALIUM)
LORAZEPAM (ATIVAN); TEMAZEPAM (RESTORIL)

side effects: amnesia; PARADOXICAL REACTIONS ESP IN ELDERLY; RESPIRATORY DEPRESSION; abuse, tolerance, physical dependence, CNS depression

contraindications: pregnancy, sleep apnea, suicidal tendencies, elderly

OD: not usually serious, drowsiness, confusion, patent airway
give FLUMAZENIL (ROMAZECON)
Term
Benzo-like drugs: ZOLPIDEM (ambien); ZALEPLON (sonata); ESZOPICLIONE (lunesta)

indication, side effects, important facts
Definition
indication: sleep aid

side effects: daytime drowsiness, dizziness, amnesia

LUNESTA WORKS LONGER, BEST FOR THOSE WHO WAKE UP IN THE MIDDLE OF THE NIGHT

less incidence of tolerance than benzos
Term
RAMELTEON (rozerem)
Definition
New sleep aid, can cause HA, sleepiness, fatigue, dizziness
Term
CAFFEINE (cafsit)

indications
weird side effects
contra indications
Definition
indications: stimulation/wakefulness; NEONATAL APNEA
weird side effects: inc HR, inc BP, BRONCHODILATION; DIURETIC;
contra indications: pregnancy; insomnia; cardiac dysrhythmias
Term
ADD/ADHD DRUGS
Definition
METHYLPHENIDATE (Ritalin, Concerta)
AMPHETAMINE (Adderall)
TRANSDERMAL METHYLPHENIDATE (Daytrana)
ATOMOXETINE (strattera)
Term
METHYLPHENIDATE (Ritalin, Concerta)
AMPHETAMINE (Adderall)

indications:
weird side effects
Definition
indications: ADD/ADHD
weird side effects: GROWTH SUPPRESSION DUE TO APPETITE SUPPRESSION; HA, GI problems, insomnia
GIVE LAST DOSE BY 4PM; TAKE DRUG HOLIDAYS
Term
TRANSDERMAL METHYLPHENIDATE (Daytrana)
Definition
patch version of Ritalin/Concerta, given for ADD/ADHD

apply to hip; no effect for 2 hours, must be put on 2 hr before school; can be removed early for dosing adjustment
Term
ATOMOXETINE (straterra)

indications
weird side effects
contra indications
Definition
ONLY FDA APPROVED FOR ADULT ADHD

indications: ADD/ADHD; off-label for depression
weird side effects: irritability; GROWTH SUPPRESSION R/T APPETITE SUPPRESSION
contra indications: MAOIs; careful w/ HTN & INC HR
Term
LEVODOPA (dopar, larodopa)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
indications: Parkinson's Disease
weird side effects: hallucinations; dyskinesias; postural hypotension; dysrhythmias; PSYCHOSIS; DARKENED SWEAT & URINE
contra indications: antipsychotics; ANTICHOLINERGICS; MAOIs

DO NOT GIVE WITH MEALS
AVOID LARRGE AMTS OF PROTEIN & B6
ON-OFF SYNDROME
DRUG HOLIDAYS
Term
LEVODOPA-CARBIDOPA (sinemet)

indications
weird side effects
contra indications
IMPORTANT FACTS
Definition
MORE EFFECTIVE THAN LEVODOPA ALONE

DOC FOR PARKINSON'S

weird side effects: hallucinations; dyskinesias; postural hypotension; dysrhythmias; PSYCHOSIS; DARKENED SWEAT & URINE
contra indications: antipsychotics; ANTICHOLINERGICS; MAOIs

OD: EYELID SPASMS, twitching, hallucinations

TAKES WEEKS/MONTHS TO WORK, BE PT
DO NOT GIVE WITH MEALS
AVOID LARRGE AMTS OF PROTEIN & B6
ON-OFF SYNDROME
DRUG HOLIDAYS
Term
Drug Class: Dopamine agonists

list drugs & common side effects & use
Definition
PRAMIPEXOLE (mirapex)
ROPINIROLE (requip)
BROMOCRIPTINE (parlodel)
PERGOLIDE (permax)

side effects: DIZZINESS & HALLUCINATIONS (DOUBLED W/LEVODOPA), DAYTIME SLEEPINESS, POSTURAL HYPOTENSION

USED W/LEVODOPA IN ADVANCED DISEASE
TOXIC PSYCHOSIS IN ELDERLY ******DON'T GIVE TO ELDERLY
Term
list drugs & common side effects & use
Definition
ENATCAPONE (Comtan)
TOLCAPONE (tasmar)

INDICATIONS: adjunct to levodopa-carbidopa (sinemet) therapy

SE: dyskinesias; OH; sleep disturbances; constipation

****DANGER OF LIVER FAILURE, ESP IN TOLCAPONE, MUST MONITOR LFTs Q 2 WEEKS/YEAR 1, Q MONTH/6 MOS, THEN Q8 WK FOREVER********
Term
DONEPEZIL (aricept)

indications
weird side effects
contra indications
Definition
indications: DOC FOR ALZHEIMER'S;only FDA approved alzheimer's drug; HALLUCINATIONS caused by Parkinson's drugs

side effects: INCONTINENCE, BRADYCARDIA, BRONCHOCONSTRICTION

contraindications: asthma, COPD, antipsychotics

BEST TOLERATED ALZHEIMER'S MED FOR ALL STAGES
contra indications
Term
atropine OD symptoms
Definition
Hot as a Hare
Mad as a Hatter
Red as a Beet
Dry as a Bone
Blind as a Bat
Term
BETHANECHOL (urecholine)

indications
weird side effects
contra indications
Definition
indications: Urinary retention, GERD

weird side effects: hypotension; DEC HR; DEC BP; BRONCHOCONSTRICTION

contra indications: PHYSICAL OBSTRUCTION OF URINARY TRACT; asthma; PUD

DO NOT TAKE WITH MEALS
Term
ATROPINE

indications
weird side effects
contra indications
Definition
indications: BRADYCARDIA; dries secretions of mucus membranes for surgery; IBS (DYSENTERY); EYE EXAMS (pupil dilaiton)

weird side effects: XEROSTOMIA; URINARY RETENTION; INCREASED INTRA-OCULAR PRESSURE; inability to sweat

contra indications: glaucoma; urinary obstruction; tachycardia; (not good with asthma & PUD, but might be use dto rescusitate)
Term
Drug Class: Anticholinergics

drug names & common seffects
Definition
ATROPINE
OXYBUTYNIN (ditropan)
TOLTERODINE (detrol)
TROSPIUM CHLORIDE (sanctura)
SOLIFENACIN SUCCINATE (vesicare)
SCOPOLAMINE (transderm-scop)

effects: sympathetic (urinary & bowel retention, thickened secretions, pupil dilation, increased HR & BP, increased IOP)
Term
OXYBUTYNIN (ditropan)
TOLTERODINE (detrol)
TROSPIUM CHLORIDE (sanctura)
SOLIFENACIN SUCCINATE (vesicare)

indications
weird side effects
contra indications
Definition
indications: OAB (OVERACTIVE BLADDER)

side effects: anticholinergic (dry mouth, constipation, dyspepsia, dry eyes, blurred vision, drowsiness)

contra indications:urinary retention, gastric retention; GLAUCOMA; high temps,
Term
SCOPOLAMINE (TRANSDERMAL SCOP)
Definition
indications: motion sickness, IBS

side effects: drowsiness, dry mouth, dilated pupils, flushing, increased HR, difficulty urinating, hallucinations

VERY TOXIC...OD SYMPTOMS: DELERIUM, DELUSIONS, PARALYSIS, STUPOR, DEATH

PHYSOSTIGMINE: OD ANTIDOTE
Term
EPINEPHRINE (adrenalin)

indications
side effects
contraindications
Definition
INDICATIONS:
*CARDIAC: inc. HR, inc. CO, inc. contractility
*BRONCHIAL: dilation
*EYE: dilation
*VASCULAR: vasoconstriction

side effects: inc. BP, inc. HR, dysrhythmias, NECROSIS ON EXTRAVASATION, hyperglycemia,
Term
NOREPINEPHRINE BITARTRATE (levophed)

indications
side effects
contraindications
Definition
indications: HYPOTENSION, CARDIAC ARREST

SIDE EFFECTS: dysrhythmias, NECROTIC EXTRAVASATION, TISSUE ISCHEMIA from vasoconstriction,
Term
ISOPROTERENOL HYDROCHLORIDE (isuprel)

indications
side effects
contraindications
Definition
indications: dysrhymias, heart block, cardiac arrest, asthma, bronchospasm

side effects: angina, hyperglycemia, dysrhythmias; PINK/RED COLORED SALIVA W/ INHALED ADMIN

contraindications
Term
DOBUTAMINE HCL (dobutrex)

indications
side effects
contraindications
Definition
indications: heart failure

side effects: TACHYCARDIA, inc. BP, dysrhythmias, ANGINA

contraindications:ANGINA
Term
Drug Class: Adrenergic Antagonists (Alpha Blockers)

drugs, indications, side effects
Definition
PHENTOLAMINE (Regitine)
PRAZOSIN (minipress)
DOXAZOSIN (cardura)

indicated: HIGH BP; reversal of epinephrine & norepinephrine (alpha stimulators); BPH (benign prostatic hypertrophy); pheochromocytoma

side effects: OH, TACHYCARDIA, nasal congestion; sexual performance
Term
PHENTOLAMINE (Regitine)

indications
side effects
contraindications
Definition
indications: pheochromocytoma; REVERSE EFFECTS OF EXTRAVASATION (SC)

side effects: OH, TACHYCARDIA, nasal congestion; sexual performance

contraindications
Term
PRAZOSIN (minipress)
DOXAZOSIN (cardura)

indications
side effects
Definition
indications:HIGH BP, enlarged prostate (BPH)
side effects: OH,TACHYCARDIA, sex problems
Term
Drug Class: Beta Blockers

drugs
indications
side effects
Definition
PROPALOLOL (inderal)
METOPROLOL (lopressor)
ATENOLOL (tenormin)

indications: angina, high BP, cardiac dysrhythmias, MI, hyperthyroidism, migraine prevention, pheochromocytoma, glaucoma

SIDE EFFECTS DEPENDENT ON B1/B2 SELECTIVITY: bradycardia, ypotension, bronchospasm, weakness, hypoglycmia, sexual dysfunction, depression, CONSTIPATION,

contraindications: Ca blockers, insulin, digoxin; heart block s pacemaker; asthma
Term
CLONIDINE (catapres)

Drug class
indications
side effects
contraindications
Definition
*decreases NE release in brain ->
Drug class: central acting a2 agonist (inhibitory in brain)



side effects:XEROSTOMIA, rebound hypertenison, DEPRESSION, NIGHTMARES, impotency/decreased libido

contraindications:BETA BLOCKERS & TRICYCLICS
Term
local anesthetics

indications
side effects
contraindications
Definition
PROCAINE (novocain)--injected, risk for allergy

LIDOCAINE (xylocaine)--topical & injected, allergic rxn rare

indications: only on normal intact skin

contraindications: antidysrhythmics, beta blockers, actetaminophen, nitrates, phenytoin, sulfonamides
Term
Inhalation anesthetics

list drugs
side effects
contraindications
Definition
NITROUS OXIDE
HALOTHANE
ENFLURANE
ISOFLURANE
DESFLURANE
SEVOFLURANE

side effects:resp/cardiac depression, aspiration, OD, HEPATOTOXICITY, MHS (MALIGNANT HYPERTHERMIA SYNDROME)

MALIGNANT HYPERTHERMIA SYNDROME TREATED WITH DANTROLENE, HAVE DANTROLENE ON HAND
Term
IV ANESTHETICS

LIST DRUGS
Definition
THIOPENTAL SODIUM (pentothal)
METHOHEXITAL SODIUM (brevital)
DIAZEPAM (valium)
LORAZEPAM (ativan)
MIDAZOLAM (versed)
PROPOFOL (diprovan)
Term
THIOPENTAL SODIUM (pentothal)
METHOHEXITAL SODIUM (brevital)

Drug class
indications
side effects
Definition
Drug class: Short-acting barbiturates (IV anesthetics)

indications: induction of anesthesia followed by inhalation

side effects: respiratory; cardiac depression
Term
DIAZEPAM (valium)
LORAZEPAM (ativan)

(in anesthesia)

indications
side effects
contraindications
Definition
indications: general anesthesia; ***used for short procedures & ICU agitation**

side effects: moderate resp & cardiac depression vs. barbs; longer onset & longer sedation

*little muscle relaxation, NO ANALGESIA
*slow onset
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