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Pharmacology Terms
General pharmacology definitions and terms
45
Pharmacology
Graduate
11/19/2012

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Term
Mechanism of Action (MOA)
Definition
-manner in which molecular targets are affected by the drug.
Term
Pharmacological Effects
Definition
-the binding of the drug at the receptor is followed by a series of signal transduction events which result in end points.
Term
Mechanism of Action (MOA)
Definition
-how the drug works.
Term
Mechanism of Action (MOA)
Definition
-example: morphine binding to and activating μ GCPRs in the brain.
Term
Pharmacological Effects
Definition
-what the drug does to the body.
Term
Pharmacological Effect
Definition
-example: morphine causing analgesia in the body.
Term
Side Effect
Definition
-predictable reactions that are bothersome.
Term
Adverse Drug Reaction
Definition
-causes the patient to stop taking that drug.
Term
Contraindications
Definition
-medications and health conditions that pose considerable risk.
Term
Dose
Definition
-how much and how often.
Term
Dose Range
Definition
-minimum to maximum dose.
Term
Dose Form
Definition
-the physical state of the drug delivered.
Term
Potency
Definition
-the concentration of the drug when it elicits 50% of its maximum response.
Term
Agonist
Definition
-elicits a response from the tissue.
Term
Full Agonist
Definition
-drug with the greatest pharmacological effect.
Term
Partial Agonist
Definition
-effects are less than the full agonist.
Term
Inverse Agonist
Definition
-causes the opposite effect of the agonist.
Term
Antagonist
Definition
-prevents the activity of the agonist.
Term
Competitive Antagonist
Definition
-binds at the same site receptor as the agonist.
Term
Non-competitive Antagonist
Definition
-binds at a different site than the agonist.
Term
Un-competive Antagonist
Definition
-can bind at a different site than the agonist even when the agonist is bound.
Term
Affinity
Definition
-tendency to bind to receptors.
Term
Efficacy
Definition
-ability to initiate a response.
Term
Intrinsic Activity
Definition
-capacity of a single drug-receptor complex to evoke a response.
Term
Allosteric Model of Drug Action
Definition
-receptors exist in more than one configuration and can be induced to fit or inhibited to inactivate.
Term
Absorption
Definition
-transfer of drug from its site of administration to the blood.
Term
Distribution
Definition
-transfer of drug from blood to tissue.
Term
Metabolism
Definition
-enzymatic conversion of drugs to more polar compounds.
Term
Excretion
Definition
-removal of drugs from the body.
Term
Oral Drug Administration
Definition
-drugs consumed via inhalation, intranasal, topical, transdermal, ocular, etc.
Term
First-Pass Effect
Definition
-the concentration of a drug is decreased when metabolized in the liver before reaching systemic circulation, but can be reintroduced to the GI tract again.
Term
Bioavailability
Definition
-fraction of unchanged drug that reaches the systemic circulation following administration by any route.
Term
Bioavailability
Definition
(drug in system)
-----------------
(drug administered)
Term
Volume Distribution (Vd)
Definition
-indicator of how drugs are dispersed among the body compartments.
Term
Half-Life
Definition
-time for the plasma concentration of a drug to be reduced by 50%.
Term
Induction
Definition
-the process of a drug inducing more enzymes to be produced by the liver for faster metabolism.
Term
Inhibition
Definition
-the unavailability of an enzyme to metabolize a drug because it is already metabolizing another drug.
Term
Therapeutic Index
Definition
(lethal dose in 50%)
-------------------
(effective dose in 50%)
Term
Certain Safety Factor
Definition
-takes biological diversity into account by using the lethal dose in 1% instead of 50%.
Term
Standard Safety Margin
Definition
(lethal dose in 1% - effective dose in 99%)
------------------------------------
(effective dose in 99% x 100)
Term
Therapeutic Window
Definition
-the range of the concentration of plasma with a drug having high probability of therapeutic success.
Term
Antagonism
Definition
-two drugs oppose each other in their pharmacological effects.
Term
Potentiation
Definition
-combination results in an effect of one that is greater than expected.
Term
Summation
Definition
-additive effects of two drugs that share the same pharmacological effects.
Term
Synergism
Definition
-the combination of drugs results in pharmacological effects that are greater than the maximum effect of each individual drug.
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