Term
This hormone decreases GnRH secretion and so decreases spermatogenesis and ovulation ? |
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Definition
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Term
If estrogens are combined with P-450 inducers like Rifampin, then effect is ? |
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Definition
Decreased contraceptive efficacy |
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Term
Tamoxifen and Raloxifene are what type of drugs ? |
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Definition
SERMs (selective estrogen receptor modulators) |
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Term
Absolute contraindications to estrogen use ? |
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Definition
1) History of thromboembolism 2) Breast and endometrial cancer 3) Pregnancy 4) Liver disease |
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Term
What drug is an antagonist at breast but agonist at bone ? |
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Definition
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Term
What drug is an estrogen receptor antagonist at all tissues, and used in trt of breast cancer in tamoxifen resistant pts ? |
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Definition
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Term
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Definition
L A E Letrozole Anastrozole Exemestane (an irreversible aromatase inhibitor) |
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Term
What drug is an estrogen antagonist in hypothalamus and in anterior pituitary, and use trt infertility ? |
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Definition
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Term
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Definition
RU 486 (Mifepristone) Danazol |
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Term
Use of RU 486 (Mifepristone) ? |
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Definition
Is a comopetitive inhibitor of progesterone and glucocorticoid receptors
Used as an abortifacient, usually given with PG-E or PG-F to increase myometrial contraction |
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Term
Danazol had what adverse effects ? |
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Definition
Hepatitis - abnormal liver function tests |
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Term
What enzyme converts testosterone to digydroxytestosterone ? |
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Definition
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Term
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Definition
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Term
Excessive use of androgens can cause ? |
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Definition
Feminization (gynecomastia, testicular shrinkage, infertility) due to conversion of exogenous testosterone to estrogen |
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Term
Exs of androgen receptor antagonists ? |
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Definition
F B N Flutamide Bicalutamide Nilutamide |
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Term
Adverse effect of Finasteride ? |
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Definition
Gynecomastia and impotence |
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Term
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Definition
Trts advanced prostate cancer that is resistant to 1st line drugs and trts Cushing's disease |
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Term
Two exs of GnRH agonists ? |
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Definition
L G Leuprolide Gonadorelin
Continuous dose (not pulsatile dose) will produce reversible medical castration |
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Term
Trts BPH and male pattern baldness |
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Definition
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Term
Queen Anne's sign (thinning of hair in lateral third of eye brow) indicates what ? |
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Definition
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Term
3 classes of drugs useful in hyperthyroidism ? |
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Definition
T I B Thioamides (Propythiouracil and Methimazole, are goitrogens)
Iodine and Iodide salts (Lugol solution and potassium iodide)
Beta blocker (propanolol) |
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Term
Why can Methimazole not be used to treat thyroid storm ? |
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Definition
It does not inhibit 5'-deiodinase in conversion of T4 to T3 |
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Term
Only medical therapy that produces permanent reduction in thyroid activity ? |
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Definition
Radioactive iodine (131 I)
Adverse effect is hypothyroidism |
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Term
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Definition
Prednisone, hydrocortisone, dexamethasone, beclomethasone, etc... |
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Term
Two corticosteroid inhibitors ? |
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Definition
Mifepristone and Spironolactone |
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Term
Cortisol (hydrocortisone) method of action ? |
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Definition
Affects transcription and translation of DNA |
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Term
Some other effects of cortisol ? |
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Definition
CNS effects, increased intracranial pressure, suppression of ACTH and other hormones, cause peptic ulcers
increase RBCs and platelets renal function is impaired development of fetal lungs |
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Term
Two synthetic glucocorticoids that can be given via aerosol ? |
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Definition
Beclomethasone Triamcinolone |
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Term
Which 2 drugs give you anti-inflammatory effects but not Na+ or K+ effects (salt-retaining effects) ? |
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Definition
Triamcinolone Dexamethasone |
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Term
Which 2 drugs give you high salt-retaining effects but no anti-inflammatory effects ? |
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Definition
Fludrocortisone Aldosterone |
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Term
What drug is used to stimulate lung maturation in fetus ? |
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Definition
IM steroids, usually dexamethasone |
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Term
What drug can be given to trt pregnant women with Cushing's ? |
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Definition
Metyrapone
Adverse effects: salt and water retention hirsutism transient dizziness GI disturbanecs |
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