Term
| Name 3 drug classes used in Cancer treatment |
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Definition
Antimetabolites
Alkylating Drugs
Cortico Steriods |
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Term
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Definition
Alklating Drugs
Alkylate Cellular DNA, interfering w/ replication of susceptible cells and causing cell death
- cancer |
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Term
Moricizine,
Disopyramide,
Lidocane,
Phenytion,
Flecainide,
Acebutolol,
Amiodarone,
Verapamil,
Adenosine,
Digoxin |
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Definition
Antiarrythmics
Act at specific sites to alter the action potential of cardiac cells and interfere with the electrical excitability of the heart. May cause new or worsened arrhythmias
-tachycardia, atrial arrhythmias |
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Term
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Definition
Antihistamines
Competitively block the effects of histamine at peripheral H1 receptor sites, have anticholinergic and antipruritic effects.
--seasonal allergic rhinitis/conjunctivitis, mild urticaria, angioedema,
dermatographism, early parkinsonian syndrome tremor, motion sickness, anaphylactic reactions, bronchoconstriction/bronchospasm |
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Term
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Definition
Antimetabolites
Antineoplastic drugs that inhibit DNA polymerase. They are cell-cycle phase-specific to S phase (of DNA synthesis) causing cell death for cells in the S phase; they also block progression of cells from G1 to S in the cell cycle
--Cancer |
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Term
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Definition
Antimigraine Drugs
Bind to serotonin receptors to cause vascular constrictive effects on cranial blood vessels
-acute migraine attacks w/or w/o aura; cluster headaches |
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Term
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Definition
Bisphosphonates
Inhibit bone resorption, possibly by inhibiting osteoclast activity and promoting osteoclast cell apoptosis which leads to decreased release of calcium from bone and decreased serum calcium level
--Paget's bone disease, osteoporosis, heterotopic ossification, hypercalcemia of malignancy, prevention of new fractures |
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Term
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Definition
Corticosteriods
Enter targe cells and bind to cycoplasmic receptors, initiating many complex reactions that are responsible for anti-inflammatory, immunosuppressive and salt-retaining actions.
--Hypercalcemia from cancer, inflammatory / allergic disorder management (RA, SLE, dermatological dis-e, status asthmaticus, autoimmune) ; hematological dis-o management, UC, acute MS, palliation of some cancer |
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Term
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Definition
Histamine 2 antagonists
Inhibit the action of histamine at the H2 receptors of the stomach, inhibiting gastric acid secretion & reducing total pepsin output; the resultant decrease in acid allows healing of ulcerated areas
--Active ulcer (duodenal / benign gastric), Hypersecretory conditions (zollinger-ellison condition), erosive GERD, prophylaxis of stress ulcer & upper GI bleeding in critically ill px, heartburn, acid indigestion, sour stomach |
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Term
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Definition
Nondepolarizing Neuromuscular Junction Blockers (NMJ Blockers)
Interfere w/neuromuscular transmission and cause flaccid paralysis by blocking acetylcholine receptors at the skeletal neuromuscular junctions
-Adjuncts to general anesthetics to facilitate endotracheal intubation and relax skeletal muscle |
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Term
| Celecoxib, Ibuprofin, naproxin |
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Definition
NSAIDS
Anti-inflammatory, analgesic, antipyretic activities largely related to inhibition of prostaglandin synthesis
- Relief of Sx: RA, OA, juvenile arthritis, mild-moderate pain, primary dysmenorrhea, fever reduction; reduction in number of adenomatous colorectal polyps |
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Term
| Fentanyl, hydrocodone, methadone, codeine, oxycodone |
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Definition
Opioids
Agonise specific opioid receptors in CNS to produce analgesia, euphoria, sedation; the receptors mediating these effects are thought to be the same as those mediating the effects of endogenous opioids
--Relief of moderate-severe acute and chronic pain; preoperative medication to sedate and allay apprehension, facilitate induction of anesthesia; intractable pain; dyspnea d/t acute left ventricular failure and pulmonary edema |
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Term
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Definition
Phosphodiesterase Type 5 Inhibitors
--treatment of erectile dysfunction in the presence of sexual stimulation |
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