Term
| Testosterone converted to DHT via.. |
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Definition
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Term
| Testosterone and androstendione are converted to estrogen via.. |
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Definition
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Term
Agonist at androgen receptors
Used to treat hypogonadism, development of 2ndary sex characteristics |
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Definition
Testosterone (methyltestosterone
toxicity:
masculinization in females, reduces intratesticular testosterone by inhibiting release of LH, gonadal atrophy. closing of epiphyseal plates |
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Term
Decrease conversion of testosterone to DHT
Used for BPH |
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Definition
Anti-Androgens:
Finasteride
Dutasteride |
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Term
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Definition
Finasteride
Dutasteride
Alpha blockers
-Zosins |
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Term
| Non steroidal competitive antagonist to testosterone |
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Definition
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Term
| Inhibits steroid synthesis by inhibiting desmolase |
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Definition
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Term
Alpha-1 antagonist used to treat BPH that is more selective
Selective more for receptor on the prostate |
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Definition
Tamulosin
No blood pressure drop |
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Term
| Oral contraception MOA and physiological effects on body |
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Definition
Drugs that will present the LH surge, ovulation does not occur.
Thin endometrium, thicken
Decrease acne by creating more Sex hormone binding globulin |
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Term
Binds estrogen receptors
Used for birth control, hypogonadism, menstrual abnormalities, HRT in postmenopausal women |
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Definition
Estrogens:
ethinyl
Toxicity: risk of endometrial bleed due to unopposed estrogen, clear cell adenocarcinoma of vagina in women exposed to DES.
Increased risk of thrombi especially with women over 35 |
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Term
| Mechanism and clinical use of Progesterone |
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Definition
Mechanism and clinical use of Progesterone
Bind to progesterone receptors
Reduce growth of endometrium
and increase vascularization of endometrium
Used in oral contraceptives and in treatment of endometrial cancer and unapposed endometrial bleeding (anti-estrogen) |
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Term
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Definition
Leuprolide
Used continuously: inhibitor
Used pulsatile fashion: stimulation
Toxicity: Menopausal symptoms |
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Term
Decreases negative feedback of estrogen on Hypothalamus pituitary axis
Induces ovulation |
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Definition
SERMs:
Clomiphene
A estrogen analog that is a partial agonist that won't give you complete negative feedback like how normal physiologic estrogen would
Toxicity:
Vision changes
Multiple births |
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Term
Aromatase inhibitor
off label use for ovulation inducer |
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Definition
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Term
| PGE analogs for inducing contractions, cervical dilations |
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Definition
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Term
Goes by RU-486
Competitive inhibitor of progestins at progesterone receptors |
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Definition
Mifepristone
Commonly given with misoprostol (PGE1)
Used for termination of pregnancy. |
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Term
| Commonly used as tocolytics |
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Definition
Magnesium
Ritodrine
Terbutaline |
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