Term
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Definition
| Smooth Muscle, Endothelium |
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Term
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Definition
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Term
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Definition
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Term
Second Messenger for:
H1
H2
H3 |
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Definition
H1 - IP3
H2 - cAMP (increase)
H3 - cAMP (decrease) |
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Term
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Definition
H1
Agonist: 2-(m-flurophenyl)-hist
Antagonist: mepyramine |
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Term
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Definition
H2
Agonist: Dimaprit
Antagonist: ranitidine |
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Term
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Definition
H3
Agonist: R-alpha-methylhistamine
Antagonist: thioperamide |
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Term
| The enzyme that converts kininogen to bradykinin |
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Definition
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Term
| B2 (bradykinin) receptor leads to what intracellular response? |
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Definition
| increase in IP3, thus increase in Ca++ |
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Term
| Bradykinin Physiological Effects |
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Definition
Pain
Vasodilation
Plasma extravasation
Eicosanoid relase (B2) |
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Term
| Biological Effects of PGI2 and PGE2: |
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Definition
PGE2 and PGI2:
Pain (hyperalgesia)
Vasodilation
PMN luekocyte Migration |
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Term
Biological Effects of:
LTB4
LTC4 |
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Definition
LTB4:
PMN Luekocyte Migration
LTC4:
Increase vascular permeability
Bronchial Smooth Muscle contration (involved in asthma) |
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Term
| Which cytokine is critically involved in Rheumatoid Arthritis? |
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Definition
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Term
| Two Classes of Anti-Inflammatory Drugs? |
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Definition
1. NSAIDS
2. Glucocorticoids |
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Term
| Two ways Glucocorticoids inhibit Inflammation? |
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Definition
1. Reduce ability of Luekocytes to migrate to inflamed tissues
2. Respond to inflam stimuli by releasing eicosaniods and active oxygen species |
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Term
| Besides regulating metabolism (inflammation), what is another biological effect of glucocorticoids? |
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Definition
| salt retention (e.g. aldosterone) |
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Term
| Mechanism of most NSAIDS? |
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Definition
| Inibit cyclooxygenase enzymes responsible for (proinflammatory) prostogandin synthesis |
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Term
| Biological Action of Asprin (salicylic acid)? |
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Definition
| Inhibit COX 1 and 2 IRREVERSIBLY |
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Term
| Therapeutic uses of Aspirin? |
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Definition
1. Anti Inflammatory
2. Pain Reducer (analgesic)
3. Fever Reducer (antipyretic)
4. Inhibition of Hemostasis (COX I in Platelets) |
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Term
| Averse effects of Salicylates? |
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Definition
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Term
| Three Types of Anti-TNF monoclonal Antibodies: |
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Definition
Infliximab (Remicade)
Adalimumab (Humira)
Etanercept (Enbrel) |
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Term
| A treatment for Rheumatoid Arthritis and Crohn's Disease? |
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Definition
| Anti TNF-alpha antibodies (Infliximab, Adalimumab, Etanercept) |
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Term
| What type of drug is Naproxen? Reversible or Irreversible action? |
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Definition
| NSAID (like Ibuprofen), reversible |
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Term
| What type of drug is Diclofenac? What is its theraputic Use? WHat is its specific toxicity? |
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Definition
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Term
| What type of drug is Sulindac? Reversible or Irreversible? |
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Definition
| NSAID (like ibuprofen), reversible |
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Term
| What type of drug is is Indomethacin? Reversible or Irreversbile? |
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Definition
| NSAID, Like Ibuprofen; reversible |
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Term
| What type of drug is Piroxocam? Reversible or Irreversbile? |
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Definition
| NSAID, Pain (anagesic; Reversible |
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Term
| What type of drug is Ketorolac? Reversible or Irreversible? |
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Definition
| NSAID, good analgesic, reversible |
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Term
| Name two drugs that are selective for one type of COX enzyme? |
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Definition
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Term
| Celecoxib and Rofecoxib are specific for what enzyme? |
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Definition
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Term
| What type of drug is Thalidomide? |
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Definition
| small molecule TNF inhibitor (in phase III testing) |
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Term
| What is the action of Acetaminophen? |
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Definition
| COX inhibitor, No COX inhibition in peripheral tissues |
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Term
| Difference between Acetaminophen and NSAIDS? |
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Definition
Lacks significant anti inflammatory effects.
No antiplatelet
No effects on Uric Acid
GI distress Minimal |
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