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Pharmacology Exam 2
Chapter 43: Anticoagulants, Antiplatelets, Thrombolytics
4
Medical
Undergraduate 1
03/05/2007

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Term
Heparin
Definition
Anticoagulant

Antidote: Protamine Sulfate

Poorly absorbed through GI and high 1st pass effect destroys much of the drug.

Highly protein bound, interacts highly with NSAIDs and Asprin and many others.

PTT and aPTT are monitored closely AR: Bleeding
Term
Warfarin (Coumadin)
Definition
Anticoagulant

Antidote: Vitamin K

Drug Action: Inhibits synthesis of Vitamin K

INR: 1.3-2 PT: 11-15 sec
Term
Plavix
Definition
Antiplatelet

To prevent reoccurance of a MI, Stroke, and prevent vascular death.

Inhibits platelet aggregation.

Increased bleeding with NSAIDs

AR: No AR's of significance.f
Term
tPA
Definition
Thrombolytic Agent

Dissolves clots, used usually following an MI, Stroke, Pulm. embolism.

Does so by conversion of plasminogen to plasmin.

Typically used in emergent situations.
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