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Pharmacology Exam 2
Ch. 11/12
82
Pharmacology
Graduate
06/29/2009

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Term
Another name for Thrombolytic Drugs
Definition
Fibrolytic
Term
Respiratory System Includes:
Definition
upper and lower airways, lungs, thoracic cavity
Term
Function of Respiratory System
Definition
to exchange oxygen and carbon dioxide from the blood in the lungs.
Term
Histamine
Definition
a substance in various body tissues, such as the heart, lungs, gastric mucoso, and skin, that is produced in response to injury
Term
Highest Concentration of Histamine found in the:
Definition
basophils (type of white blood cells) and mast cells (found near the capillaries)
Term
Antihistamines
Definition
Drugs used to counteract the effects of histamine on the body organs and structures
Term
What are Decongestiants used for?
Definition
Temporary relief of common cold, hay fever, nasal congestion, resp. allergies, and sinusitus.
Term
what is a Decongestiant
Definition
A drug that reduces swelling of the nasal passages, which in turn opens clogged nasal passages and enhances drainage in the sinuses.
Term
Antihistamines Treat
Definition
seasonal allergies, conjuntivitis, relief of nausea and vomitting, treatment of parkinsonism, sedation, rhinitus
Term
Decongestiants
Definition
sympathomimetic drugs which priduce localized vasocontriction of the small blood vessels of the nasal membranes
Term
What are decongestiants used for:
Definition
trat the congestion associated with thinitis hay fever, allergic shinitis, sinusitus, and the common cold, also aduchtive therapy for middle ear ingections of decrease in congestion around eustacion tubes
Term
3 types of asthma
Definition
exinsic, intrinsic, and mised asthma
Term
Extrinsic aka...
Definition
allergic asthmas
Term
Intrinsic Asthma aka
Definition
non allergic asthma
Term
Intrinsic asthma is
Definition
caused by chronic or recurrent respiratory ingections, emotional upset and excersise
Term
Mixed Asthma is
Definition
caused by extrinsic and intrinsic asthma
Term
anemia
Definition
a decrease in the number of blood cells (RBC's), a decrease in the amount of hemoglobin in RBCs, or both decrease in number of RBCs and hemoglobin
Term
fibroltyc drugs
Definition
another name for thrombolytic drugs
Term
folinic acid or leucovorin rescue
Definition
the tecnique of administering leucovorin after large dose of methotrexate to rescue normal cells and allow them to survive.
Term
hemostasis
Definition
a process that stops bleeding in a blood vessel
Term
intrinsic factor
Definition
a substance produced by cells in the stomach that is necessary for the absorption of vitamin B12 in the intestine
Term
iron deficiency anemia
Definition
condition that results when the body does not have enough iron to supply the bodies needs.
Term
megaloblastic anemia
Definition
a type of anemia that results from a deficiency of folic acid and certain other causes.
Term
pernicious anemia
Definition
a type of megaloblastic anemia that results from a dificiency of intrinsic factor
Term
prothrombin
Definition
a substance that is essential for the clotting of blood
Term
thrombrosis
Definition
the formation of a clot
Term
thrombus
Definition
blood clot
Term
Anticoagulants are used to prevent the formation and extension of a _______
Definition
Thrombus (blood clot).
Term
Anticoagulants include:
Definition
warfarin, anisdione, and fractionated and unfractionated heparin
Term
Warfarin is the oral __________ most commonly prescribed.
Definition
anticoagulant.
Term
Most common adverse reaction of Warfarin
Definition
bleeding
Term
Heparin in hibits the formation of:
Definition
fibrin clots, the conversion of fibrinogen to fibrin, and inactivates several of the factors necessary for clotting of blood.
Term
Chief complication of Heparin administration:
Definition
Hemorrhage
Term
Thrombolytics are a group of drugs that are used to dissolve certain types of blood clots and reopen blood vessels after they have been occluded...T of F
Definition
True
Term
Most common adverse reaction of a thrombolytic drug:
Definition
Bleeding
Term
4 types of anemia:
Definition
1. iron deficiency
2. anemia in chronic renal failure (CRF)
3. Pernicious Anemia
4. Folic Acid deficiency
Term
Bile Acid Sequestrants are used as _______________-
Definition
adjuctive therapy to reduce elevated serum cholesterol in patients with hypercholesterolemia who do not adequetely repond to a diet and excersise program.
Term
COmmon side effect of Bile acid sequestrants
Definition
constipation
Term
What is used to trear hyperlipidemia?
Definition
HMG-CoA reductase inhibitors, along with a diet restricted in saturated fat and cholesterol.
Term
rhabdomyolysis is a adverse reaction of:
Definition
HMG CoA reductase inhibitors.
Term
Niacin is used as adjuctive therapy for the treatment of:
Definition
very high serum triglyceroid levels in patiends at risk for pancreatis.
Term
atherosclerosis
Definition
a disorder in which lipid deposits accumulate on the lining of the blood vessels, eventually producing degenerative changes and obstruction of blood flow.
Term
bile acid sequestrants:
Definition
these drugs bind to bile acids to form an insoluble substance that cannot be absorbed by the intestine, so it is excreted in the feces.
Term
catalyst
Definition
a substance that accelorates a chemical reaction without itself undergoing change.
Term
cholesterol
Definition
one of the lipids in th eblood
Term
HDL
Definition
high density lipoproteins
Term
high density lipoproteins
Definition
carry cholesterol from peripheral cells to the liver where it is metabolozed and excreted.
Term
HMG CoA reductase inhibitors:
Definition
an enzyme that is a catalyst in the manufacture of cholesterol.
Term
hyperlipidemia
Definition
an increase (hyper) in lipids (lipid), which are fats or fat-like substances, in the blood (emia).
Term
lipids
Definition
fat or fat like proteins in the blood
Term
lipoprotein
Definition
a lipid containing protein
Term
low density lipoproteins (LDL)
Definition
transport cholesterol into peripheral cells
Term
rhabdomyolysis
Definition
a rare condition in which muscle damage results in the release of muscle cell contents into the blood stream
Term
trigylceroids
Definition
a type of lipds in the blood.
Term
Low density lipoproteins (LDL)...Harmful lipoprotein
Definition
true
Term
high density lipoprotein (HDL)..protective lipoprotein
Definition
true
Term
Antihyperlipidemic Drugs Contain:
Definition
Bile Acid Sequestrants,
HMG CoA reductase inhibitors,
Fibric Acid Derivatives,
Niacin,
Garlic
Term
Garlic
Definition
lowers blood pressure, imrpoves ration of HDL to LDL cholesterol levels, prevents atherosclerosis..
Term
Antianginal drugs include:
Definition
nitrates,
calcium channel blockers,
Term
angina
Definition
a disorder caused by atheroscerotic plaque formation in the coronary arteries, which causes decreased oxygen supply to the heart muscle and results in chest pain or pressure.
Term
artheroscerosis
Definition
a disease characterized by deposits of fatty plaques on the inner wall of arteries.
Term
intermittent claudication
Definition
a group of symptoms characterized by pain in the calkf muscle of one or both legs; caused by walking and relieved by rest.
Term
lumen
Definition
the inside diameter of a vessel such as an artery.
Term
prophylaxis
Definition
prevention
Term
transdermal systerm
Definition
a convenient form of drug administration in which the drug is impregnated into a pad and absprbed through the skin
Term
vasodilation
Definition
an increase in the size of blood vessels, primarily small arteries and arterioles
Term
Nitrates have a ______ effect on the smooth muscle layer of blood vessels.
Definition
relaxing
Term
Peripheral vasodilating drugs are given for disorders that effect ___
Definition
blood vessels of the extremities. by decreasing blood flow.
Term
Cardiotonics, Miscellaneous Inotropic, and Antiarrhythmic drugs are used for _______ _________
Definition
heart conditions
Term
action potential
Definition
an electrical impulse thqat passes from cell to cell in the myocardium, stimulating fibers to shorten and causing muscular contration (systole)
Term
atrial fibrilation
Definition
a cardiac arrhythmia charecterized by rapid contractions of the atrial myocardium, resulting in an irregular and often rapid ventricular rate
Term
arrhythmia
Definition
a disturbance or irregularity in the heart rate or rhythm or both.
Term
blockade effect
Definition
the action of antiarrhythmic drugs blocking stimulation of beta receprors of the heart by adrenergic neurohormones
Term
cardiac output
Definition
the amount of blood leaving the left ventricle with each contraction
Term
cinchonism
Definition
a term for quinidine toxicity
Term
depolarization
Definition
the movement of a stimulus passing along the nerve, the positive ions move from outsoide the cell into the cell. and the negative ions move from inside the cell to outside the cell.
Term
digitalization
Definition
a series of digitalis doses given until the drug begins to ecert a fiull therapuetic effect.
Term
ejection fraction
Definition
the amount of blood that the ventricle ejects per beat in a relationship to the amount of blood avaulable to eject
Term
hear failure
Definition
denoted bu the initial ventricle dysfunction.
Term
ischemic
Definition
marked by reduced blood flow caused by arterial narrowing or blockage or other causes.
Term
left ventricular dysfuntion
Definition
most common form of heart failure
Term
polarization
Definition
the point at which positive ions on the outside and negative ions on the inside of a cell membrane are in equilibrium.
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