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Pharmacology CHAPTER 40
Upper Respiratory
32
Nursing
Undergraduate 3
04/01/2014

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Term
acute pharyngitis
Definition
inflammation of the throat,
Term
acute rhinitis
Definition
acute inflammation of the mucous membranes of the nose
Term
allergic rhinitis
Definition
often called hay fever, which is caused by pollen or a foreign substance (e.g., animal dander).
Term
rhinorrhea
Definition
watery nasal discharge
Term
Antihistamines
Definition
H1 blockers or H1 antagonists
Term
When the H1 receptor is stimulated
Definition
the extravascular smooth muscles, including those lining the nasal cavity, are constricted.
Term
stimulation of the H2 receptor,
Definition
an increase in gastric secretions occurs, which is a cause of peptic ulcer
Term
First-Generation Antihistamines
Definition
Most first-generation antihistamines cause drowsiness, dry mouth, and other anticholinergic symptoms,
Term
second-generation antihistamines
Definition
have fewer anticholinergic effects and a lower incidence of drowsiness.
Term
The anticholinergic properties of most antihistamines cause
Definition
dryness of the mouth and decreased secretions, making them useful in treating rhinitis caused by the common cold. Antihistamines also decrease the nasal itching and tickling that cause sneezing.

The
Term
first-generation antihistamine example
Definition
diphenhydramine (Benadryl)
Term
second-generation antihistamines example
Definition
etirizine (Zyrtec), fexofenadine (Allegra), and loratadine (Claritin) Azelastine (Astelin,)
Term
Diphenhydramine can be administered
Definition
orally, intramuscularly (IM), or intravenously (IV). It is well absorbed from the gastrointestinal (GI) tract, but systemic absorption from topical use is minimal.
Term
Diphenhydramine blocks the effects of histamine by
Definition
competing for and occupying H1 receptor sites
Term
antitussive
Definition
act on the cough-control center in the medulla to suppress the cough reflex
Term
Diphenhydramine Contraindications
Definition
Acute asthmatic attack, severe liver disease, lower respiratory disease, neonate; MAOIs
Term
Nasal decongestants
Definition
stimulate the alpha-adrenergic receptors, producing vascular constriction (vasoconstriction) of the capillaries within the nasal mucosa. The result is shrinking of the nasal mucous membranes and a reduction in fluid secretion (runny nose).
Term
Frequent use of decongestants, especially nasal spray or drops
Definition
can result in tolerance and rebound nasal congestion (rebound vasodilation instead of vasoconstriction). Rebound nasal congestion is caused by irritation of the nasal mucosa.
Term
Systemic decongestants (alpha-adrenergic agonists)
Definition
ephedrine (Ephedrine), phenylephrine (Neo-Synephrine), and pseudoephedrine (Sudafed).
Term
Intranasal glucocorticoids
Definition
steroids
Term
ntranasal glucocorticoids are effective for treating
Definition
allergic rhinitis
Term
Antitussives example
Definition
Dextromethorphan, a nonnarcotic antitussive, is widely used in OTC cold remedies
Trade Names: Robitussin,
Term
antitussives side effects
Definition
Nausea, dizziness, drowsiness, sedation
Term
3 antitussive types
Definition
nonnarcotic, narcotic, or combination preparations. Antitussives are usually used in combination with other agents
Term
Expectorants
Definition
loosen bronchial secretions so they can be eliminated by coughing.
Term
Sinusitis
Definition
is an inflammation of the mucous membranes of one or more of the maxillary, frontal, ethmoid, or sphenoid sinuses.
Term
A client tells the nurse that he has started to take an OTC antihistamine, diphenhydramine. In teaching him about side effects, what is most important for the nurse to tell the client?
a. Do not to take this drug at bedtime to avoid insomnia.

b. Avoid driving a motor vehicle until stabilized on the drug.

c. Nightmares and nervousness are more likely in an adult.

d. Limit use to 1 to 2 puffs/sprays 4 to 6 times per day to avoid rebound congestion.
Definition
B
Term
The client complains of a sore throat and has been told it is due to beta-hemolytic streptococcal infection. The nurse realizes this condition is called what?

a. Acute rhinitis.

b. Acute sinusitis.

c. Acute pharyngitis.

d. Acute rhinorrhea.
Definition
C
Term
A client is prescribed the decongestant oxymetazoline (Afrin) nasal spray. What should the nurse teach the client?

a. Take this drug at bedtime as a sleep aid.

b. Directly spray away from the nasal septum and gently sniff.

c. This drug may be used in maintenance treatment for asthma.

d. Limit the drug to 5 days of use to prevent rebound nasal congestion.
Definition
D
Term
A client has been prescribed guaifenesin (Robitussin). The nurse realizes that the purpose of the drug is to accomplish what?

a. To treat allergic rhinitis and prevent motion sickness

b. To loosen bronchial secretions so they can be eliminated by coughing

c. To compete with histamine for receptor sites, thus preventing a histamine response

d. To stimulate alpha-adrenergic receptors, thus producing vascular constriction of capillaries in nasal mucosa
Definition
B
Term
Beclomethasone (Beconase) has been prescribed for a client with allergic rhinitis. The nurse teaches the client that which is the most common side effect from continuous use?

a. Dizziness

b. Rhinorrhea

c. Hallucinations

d. Dry nasal mucosa
Definition
D
Term
The nurse is teaching a client about diphenhydramine (Benadryl). Which are topics to include? (Select all that apply.)

a. Take medication with food to decrease gastric distress.

b. Avoid alcohol and other central nervous system depressants.

c. Notify the health care provider if confusion or hypotension occurs.

d. Take sugarless candy, gum, or ice chips for temporary relief of dry mouth.

e. Avoid handling dangerous equipment or performing dangerous activities until stabilized on the drug.
Definition
ALL OF THE ABOVE
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