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Pharmacology Chapter 6 Sulfa Class (Galen final)
Pharmacology Final
40
Pharmacology
Undergraduate 1
12/22/2011

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Term
Sulfonamides
Definition
the first antibiotic drugs developed that effectively treated infections
Term
bacteriostatic
Definition
they slow or retard the multiplication of bacteria
Term
bactericidal
Definition
they destroy the bacteria
Term
broad spectrum
Definition
they destroy a large number of different types of bacteria from the same strain, such as gram negative bacteria
Term
narrow spectrum antibiotics
Definition
drugs that are specific to particular bacteria
Term
bacterial reistance
Definition
ability of bacteria to produce substances that inactivate or destroy the antibiotic
Term
antibacterial agents
Definition
they are active against bacteria
Term
sulfonamide actions
Definition
are primarily bacteriostatic because of their ability to inhibit the activity of folic acid in bacterial cell metabolism
Term
sulfonamide uses
Definition
UTIs and acute otitis media
Ulcerative colitis
Term
Sulfa uses
Mafenyde (Sulfamylon) and silver sulfadiazine (Silvadene)
Definition
are topical sulfonamides used in the treatment and prevention of infections in second and third degree burns.
Term
Adverse Reactions Sulfa
Definition
Anorexia, NVD, abdominal pain, and Stomatitis (inflammation of the mouth)
Term
Sulfa-Other reactions
Definition
Chills, fever, Crystalluria (crystals in the urine), photosensitivity
Term
hypersensitivity to sulfa
Definition
urticaria (hives), pruritus (itching), Toxic Epidermal Necrolysis (TEN), or Steven Johnson's Syndrome (SJS)
Term
signs of SJS
Definition
lesions on the skin and mucous membranes, eyes. Lesion may apprea as red wheals or blisters, often starting on the face, mouth, lips, neck and extremities.
Term
sulfa most common adverse reaction with topical application
Definition
is burining sensation or pain when the drug is applied to the skin
Term
hematologic changes during prolonged sulfa therapy
Definition
leukopenia-decrease in # of WBC
thrombocytopenia-decrease in # of
platelets
aplastic anemia- anemia due to deficient RBC production in the bone marrow
Term
sulfa precautions
Definition
renal impairment, hepatic impairment, or bronchial asthma
Term
Contraindications to Sulfa's
Definition
hypersensitivity, during lactation, and children under 2 years of age, not used at the end(at term) pregnancy
Term
Sulfa's are used with caution in pts with
Definition
renal impairment, hepatic impairment, or bronchial asthma, pregnancy Cat C
Term
Interactions for Sulfa':
Oral anticoagulants
Methotrexate
hydantoins
Definition
increased action of anticoagulants
increased bone marrow suppression
increased serum hydantoin level
Term
hypoglycemic reaction
Definition
when diabetic pts are prescribed sulfa's assess for a possible
Term
Cranberries/cranberry juice
Definition
Used to treat UTIs
Term
what self-remedies have you tried before seeking a health care provider
Definition
During the pre-admin assessment ensure you ask?
Term
urine culture, urinalysis, complete blood count, intravenous pyelogram, renal function tests, and examination of the stool
Definition
What tests are reviewed?
Term
evaluates response to the drug; relief of symptoms and a decrease in temp.(if temp increases report to HCP immediately)
Definition
ongoing assessment the nurse?
Term
stool samples, contact HCP if changes in number and appearance.
Definition
If taking sulfasalazine for ulcerative colitis, ensure the pt inspects all?
Term
1-2 hours
Definition
If administering a sulfa for a burn, the nurse inspects the areas every?
Term
1.Impaired urinary elimination-related to effect on the bladder from sulfa's
2.Impaired skin integrity- related to burns
3.Impaired skin integrity-related to photosensitivity or sever allergic reaction to sulfa
4.risk for(secondary)infection-lowered WBC count resulting from sulfa therapy
Definition
Nursing diagnosis
Term
prevent
Definition
People may be receiving this to ____
infection?
Term
1-2 hours after meals
Definition
They are given at what time?
Term
sulfasalazine
Definition
May cause urine and skin to take on an orange-yellow color; normal
Term
8
Definition
Instruct pt to drink a full glass of water when taking an oral sulfa, and at least __ glasses a day until therapy is finished
Term
2000
Definition
Drink at least ____ml or more per day to prevent crystalluria and stones. Also important to measure intake/output
Term
incontinence
Definition
renal impairmant is common in older adults, there is an increased danger of the sulfa causing additional renal damage, and may be hesistant about the increase of fluids because of the fear of...
Term
1/16
Definition
If applying the topical sulfa for a burn, use a sterile glove and apply __ inch thick
Term
protective clothing and sunscreen when outside; and should be inspected 14 days after therapy in which reactions can still occur
Definition
Due to photosensitivity the pt should be cautioned to wear
Term
leukopenia(may result in signs of an infection) and thrombocytopenia.
Definition
Nurse monitors for ___ and ___ (risk for secondary infection)
Term
fever, sore throat, and cough
Definition
Leukopenia may result in S/S of an infection such as
Term
easy bruising and unusual bleeding after moderate to slight trauma to skin or mucous membranes
**use soft-bristled toothbrush**
Definition
Thrombocytopenia is manifested by
Term
fever,skin rash, other skin problems, N, V, unusual bleeding or bruising, sore throat or extreme fatigue
Definition
Notify the primary HCP immediately if the following should occur
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