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Pharmacology Chapter 20
NWTC Pharmacology chapter 20
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Pharmacology
Undergraduate 2
03/15/2010

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Term
Psychotropic definition
Definition
therapeutic effect on a person's mental processes, emotions, or behavior
Term
Psychotropic classification
Definition
CNS stimulants
Antidepressants
anxiolytics
antipsychotics
Term
CNS Stimulants
Definition
promoting CNS functioning
caffeine citrate
amphetamines
methylphenidate/Ritalin
Term
CNS stimulant side effects
Definition
nervousness, insomnia, irritability, seizures, psychosis - od
Tachycardia, palptations, arrhythmias, hypertension
GI, anorex, n, v, abd pain, dry mouth
habituation, dependence
Term
CNS stimulant contraindications
Definition
obesity, not more than 6 weeks
anxiety, agitation
hx of dependence
hyperthyr
cv disorders
closed angle glaucoma
pregnant, nursing
abrupt withdrawl causes depression
MAOI
Term
CNS stimulation children's contraindications
Definition
growth, weight, tics, tourettes
Term
modafinil/Provigil
Definition
psychostimulant\
narcolepsy, sleep apnea, shift-work sleep disorder
Term
Caffeine Citrate
Definition
PO
neonatal apnea
Term
amphetamines/Adderall
Adderall XR
Definition
ADD, ADHD, narcolepsy, older than 3
Term
methylphenidate/Ritalins, Metadates (ER & CD) Concerta
Definition
narcolepsy
ADD, ADHD older than 6
senile apathy, major depression
Term
atomoxetine/Strattera
Definition
ADHD
black box suicidal
Term
Selective Norepinephrine Reuptake Inhibitor SNRI
Definition
atomoetine/Strattera
non stimulant, noncontrolled ADHD
over 6 years old
Term
Antidepressants
Definition
prevent early absorption of neurotransmitters serotonin, norepinephrine, and dopamine
Term
Antidepressant classification
Definition
Tricyclic
MAIO
SSRI
Heterocyclic
Term
Tricyclic antidepressant
Definition
block reuptake presynaptically and potentiates serotonin and norepinephrine
fewer side effects than MAOI's
more effective than SSRI's in severe depression
adjunct in neurogenic pain control
slightly sedative, slow onset 2-4 weeks
Term
Tricyclic side effects
Definition
Dryness of mouth
drowsiness, dizziness
constipation, urinary retention esp BPH
postural hypotension
confusion older adults
Term
Tricyclic contraindications
Definition
Cardiac, renal, hepatic
older adults
glaucoma
obesity
preg/lac
MAOI
SSRI increase tricyclic blood levels
Term
Tricyclic interactions
Definition
Clonidine - hypertensive crisis
CNS drugs and alcohol
Term
Monoamine Oxidase Inhibitors
Definition
increase concentrations of serotonin, norephinephrine, dopamine in neuronal synapse by inhibitin MAO enzyme
Used in refractory or atypical depression
Panic disorder, phobias
Term
MAOI side effects
Definition
nervousness, agitation, insomnia
headache
hypertension/crisis
tachycardia, palpitation, chest pain
Term
MAOI contraindications
Definition
Cerebrovascular, heart, liver, renal
under 16 yo
preg/lac
abrupt discon.
Term
MAOI interactions
Definition
adrenergic drugs, diuretics, insulin
Levodopa, antidepressants
CNS depressants
Food: tryamine, tryptamine, tryptophan
gogurt sc, cheese, chicken liver, pickled herring bananas pineapple avocados, figs, pea pods, tenderizers, alcohol, fermented/aged
Term
MAOI's
Definition
isocarboxazid/Marplan
phenelzine/Nardil
tranylcypromine/Parnate
selegilene/Eldepryl - selective MAOI, parkinson's
Term
Selective Serotonin Reuptake Inhibitors
Definition
1st line, fewer side effects
block reabsorption of serontonin
one to four weeks
Term
SSRI side effects
Definition
nausea, anorexia
insomnia, anxiety, nervousness, tremor, drowsiness, fatigue, dizziness, headache
Term
SSRI cautions
Definition
liver, renal
suicide prone
diabetwes
bipolar, can precipitate manic attacks
underweight, eating disorders
preg/lac
Term
SSRI Interactions
Definition
CNS drugs
MAOI's
Antiarrhythmics, anticoagulants, beta blockers, calcium channel blockers
Term
Heterocyclic antidepressants
Definition
2nd generation
buproprion: activating antidepressant
mirtazapine/Remeron: calming antindepressant (fibromyalgia), weight gain
Trazadone/Desyrel: highly sedating, agitation secondary to dementia
Term
Heterocyclic side effects
Definition
Drowsiness,(not buproprion) insomnia, restlessness, agitation, anxiety (with buproprion)
dry mouth, nausea, dizziness confusion
weight gain (Trazodone, Mirtazapine)
Term
Heterocyclic cautions/interactions
Definition
suicide, seizure, cardiac, liver
CNS drugs, antidiabetic agents, MAOI's
Term
Antimanic agent
Definition
Lithium
Mood stabilizers: anticonvulsants, valproate(Depakote, Depakene, and carbamazepine (Tegretol)
Symbax
atypical antipsychotics: olanzaprine, quetiapine, risperidone
Term
Lithium
Definition
long term treatment bi polar 0.8-1.5 meq. therapeutic range
Term
Lithium side effects
Definition
GI distress
cardiac arrhythmias, hypotension
tremors
Term
Lithium cautions
Definition
seizure, parkinson
cardiovas, kidney
older/debilitated
thyroid disease
Term
Amitriptyline/Elavil
Definition
tricyclic, interact with CNS, give hs
po
Term
desipramine/Norpramin
Definition
tricyclic
anticholinergic SE, orthostatic hypotention, less sedation
Term
doxepin/Sinequan, Adapin
Definition
also used topically for eczema
tricyclic
po
Term
imipramine/Tofranil
Definition
tricyclic
enuresis
po
Term
nortriptyline/AVentyl, Pamelor
Definition
lower dose adolescents and older adults
tricyclic
Term
isocarboxazid/Marplan
Definition
MAOI
po
Term
phenelzine/Nardil
Definition
MAOI
po
Term
tranylcypromine/Parnate
Definition
MAOI
po
Term
citalopram/Celexa
Definition
SSRI
am or pm without food
Term
escitalopram/Lexapro
Definition
SSRI
better tolerated than Celexa
po
Term
escitalopram/Lexapro
Definition
SSRI
better tolerated than Celexa
po
Term
fluoxetine/Prozac
Definition
delayed response, long half life
am
po
SSRI
Term
paroxetine/Paxil
Definition
older 1/2 dose, am, no antacids
SSRI
Term
sertraline/Zoloft
Definition
am
SSRI
Term
venlafaxine/Effexor
Definition
SSRI
pc to lessen nausea
don't crush
Term
buproprion/Wellbutrin
Definition
Heterocyclic
early in day, increase grad/seizures
Term
mirtazapine/Remeron
Definition
Heterocyclic
bedtime, sedation is common
Term
trazadone/Desyrel
Definition
Heterocyclic
pc to decrease nausea, bedtime if drowsiness
Term
lithium/Lithobid, Eskalith
Definition
antimanic agent
ther: 0.8-1.5 meq
Term
carbamazepine/Tegretol
Definition
antimanic agent
4-12 mcg
Term
valproate/Depakote, Depakene,
Definition
antimanic
migraine prophylaxis
Term
olanzapine/fluoxetine/ Symbax
Definition
antimanic agent
bipolar
Term
Anxiolytics
Definition
antianxiety, minor tranquilizers
benzodiazepines
treat: anxiety d/o
neurosis
psychosomatic, insomnia
n, v
Term
Anxiolytic side effects
Definition
depression, hallucination, confusion, agitation, bizarre behavior, amnesia
drowsiness, lethargy, headache
ataxia, tremor, extrapyramidal reactions
sensitivity to sunlight
Term
Anxiolytic contraindications
Definition
mental depression
suicidal tendencies
depressed vital signs
preg/lac/children
liver and kidnehy
older and debilitated (paradoxical reactions)
Term
Anxiolytic interactions
Definition
CNS depressants
digitalis, phenytoin
grapefruit juice - valium
Term
midazolam/Versed
Definition
potent, used preoperatively anxiety, sedation, light anesthesia, amnesia, conscious sedation
Term
midazolam/Versed side effects
Definition
depressed respiration large doses and copd
paraoxical reactions
n and v
Term
midazolam/Versed cautions
Definition
apnea, hypoxia, cardiac arrest
respiratory equipment available
Electrolyte imbalance, renal impairment, CHF, children
NO: pregnancy, comatose, narrow-angle glaucoma
Term
midazolam/Versed interactions
Definition
CNS depressants potentiate respiratory probs
Cimetidine/Tagamet and ranitidine/Zantac potentiate respiratory
Erythromycin, ketoconazole, itraconazole, diltiazem, verapramil potentiate respira
Term
buspirone/BuSpar
Definition
antianxiety, not benzodiazepine
cognitive and interpersonal problems
slower onset, two to four weeks
Term
buspirone/BuSpar side effects
Definition
dissiness, drowsiness, ha
GI
Term
hydroxyzine/Vistaril, Atarax
Definition
antianxiety
short term, not benzodiazepine
Term
alprazolam/Xanax
Definition
XR panic disorder, no abrupt wdrawal
benzodiazepine
Term
chlordiazepoxide/Librium
Definition
benzodiazeprine
alcohol withdrawal, severe anxiety IV/IM
Term
chlorazepate/Tranxene
Definition
older adults no more than 15mg
benzodiazepine
Term
diazepam/Valium
Definition
benzodiazepine
muscle relaxant, IV status epilepticus
don't mix in syringe
Term
lorazepam/Ativan
Definition
benzodiazeprine
older agitated adults
Term
oxazepam/Serax
Definition
benzodiazepine
older agitated adults
Term
buspirone/BuSpar
Definition
anxiolytics
slow onset
long term
Term
hydroxyzine/Atarax
Definition
antiemetic, antipruritic, preoperative
anxiolytic
Term
Vistaril
Definition
anxiolytic
antihistamine
Term
antipsychotic
Definition
major tranquilizers
phenothiazines (typical)
Term
antipsychotic areas
Definition
relieving symptoms of psychoses, severe neuroses
relieving N & V
potentiation of analgesics
Term
typical antipsychotices
Definition
phenothiazines
chlorpromazine/Thorazine
block dopamine receptors, unbalance cholinergic activity that can cause extrapyramidal side effects and tardive dyskinesia
Term
atypical antipsychotics
Definition
risperdone
block serotonin and dopamine receptors
less EPS and TD
behavioral and psychological symptoms of dementia
Term
antipsychotic side effects
Definition
insomnia, agitation, depression, HA,
seizures
dry mouth blurred vision, fever
constipationk urinary retention, anorexia
Parkinsonian symptoms more common in older
Term
antipsychotic contraindicaqtion
Definition
do not treat EPS and TD with Artane or Congentin (Park) will make worse, regular assessment for TD, AIMS scale and DISCUS
Term
AIMS
DISCUS
Definition
Abnormal Involuntary Movement Scale
Dyskinesia Identification System: Condensed User Scale.
Term
antipsychotic contraindications
Definition
seizure disorders
Parkinsonian syndrome
cerebral vascular diseaswe
severe depression
pregnancy
blood dyscrasias
cautions: older, children, hepatic, cvk, renal prostatic hypertrophy, diabetes
Term
antipsychotic interactions
Definition
potentiation CNS depressants, anticholinergics, antihypertensives
antagonism with anticonvulsants
Term
chlorpromazine/Thorazine
Definition
typical antipsychotic
agitation, N & V, severe behav problems
Term
haloperidol/Haldol
Definition
typical antipsychotic
agitation schizophrenia and delusions in older adults
Term
prochlorperazine/Compazine
Definition
typical antipsychotic
agitation, primarily N & V
Term
thioridazine/Mellaril
Definition
typical antipsychotic
psychoneurosis, agitation, combativeness
Term
trifluoperazine/Stelazine
Definition
typical antipsychotic
tranq for psychotic disorder
Term
thiothixene/Navane
Definition
chronic schizophrenic or behavioral management of withdrawn patients
typical antipsychotic
Term
fluphenzine HCI/Prolixin
Definition
reduce dose for older
typical antipsychotic
Term
perphenazine/Trilafon
Definition
typical antipsychotic
psychosis, N & V in adults
Term
aripiprazole/Abilify
Definition
atypical antipsychotic
schizophrenia
Term
clozapine/Clozaril
Definition
atypical antipsychotic
monitor wbc risk of agranulocytosis
Term
olanzapine/Zyprexa
Definition
atypical antipsychotic
reduce dose for older
acute agitation
Term
quetiapine/Seroquel
Definition
atypical antipsychotic
watch for orthostatic hypotension
Term
risperidone/Risperdal
Definition
atypical antipsychotic
reduce by half for older
schizophrenia
Term
ziprasidone/Geodon
Definition
atypical antipsychotic
acute psychosis/agitation
risk of cardiac
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