Term
Treatment for Lead Toxicity for adults and children |
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Definition
Adults: EDTA Succimer
Children: EDTA Dimercaprol Succimer |
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Term
Lead toxicity inhibits these enzymes |
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Definition
aminolevulinic acid dehydrogenase Ferrochetolase |
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Term
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Definition
Copidogrel (plavix) Ticlopidine --blocks the ADP receptor on platelets so that GpIIb/IIIa cannot be expressed Consider using this in patients who cannot use Warfarin.
Asprin --Prevents creation of TXA2
Abxicimab --Antibody against GpIIb/IIIa |
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Term
Drug treatment for Von Willebrand's Disease |
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Definition
DDVAP - analog of vasopressin
"squeezing" the good vWF out of the endothelial cell |
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Term
Drug used for Acute anti Coagulation |
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Definition
Heparin
MOA: stimulates Antithrombin III to decrease thrombin and factor Xa. Monitor via intrinsic pathway PTT.
Does not cross placenta. Safe for pregnant women. |
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Term
Drug used for chronic anti coagulation |
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Definition
Warfarin
MOA: inhibits epoxide reductase. Decreases the Vitamin K dependent clotting factors (II,VII,IX,X,C,S). Monitor via PT levels
May produce a transient hypercoagulable state (acts on protein C/S first). Coadminister with Heparin
Teratogenic, crosses placenta to cause hydrops |
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Term
Drug used for its thrombolytic activity |
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Definition
tPA (alteplase) streptokinase urokinase
MOA: converts plasinogen to plasmin
Used for ischemic strokes, Myocardial infarction therapies. |
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Term
Treatment for Heparin Toxicity |
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Definition
Protamine sulfate
positively charge molecules bind to negatively charged Heparin molecules. |
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Term
Treatment for Warfarin toxicity |
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Definition
Vitamin K (to restore clotting factors) Fresh Frozen Plasma (to immediately address hemorrhage) |
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Term
Treatment for thrombolytic toxicity |
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Definition
Aminocaproic acid
Inhibitor of fibrinolysis |
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Term
Drug used for Heparin Induced Thrombocytopenia |
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Definition
Lepuridin Bivalirudin
Directly decreases thrombin |
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Term
Drug treatment for Sickle Cell patients |
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Definition
Hydroxyurea (in addition with fluid therapy) |
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