Term
| Treatment for Lead Toxicity for adults and children |
|
Definition
Adults:
EDTA
Succimer
Children:
EDTA
Dimercaprol
Succimer |
|
|
Term
| Lead toxicity inhibits these enzymes |
|
Definition
aminolevulinic acid dehydrogenase
Ferrochetolase |
|
|
Term
|
Definition
Copidogrel (plavix)
Ticlopidine
--blocks the ADP receptor on platelets so that GpIIb/IIIa cannot be expressed
Consider using this in patients who cannot use Warfarin.
Asprin
--Prevents creation of TXA2
Abxicimab
--Antibody against GpIIb/IIIa |
|
|
Term
| Drug treatment for Von Willebrand's Disease |
|
Definition
DDVAP - analog of vasopressin
"squeezing" the good vWF out of the endothelial cell |
|
|
Term
| Drug used for Acute anti Coagulation |
|
Definition
Heparin
MOA: stimulates Antithrombin III to decrease thrombin and factor Xa. Monitor via intrinsic pathway PTT.
Does not cross placenta. Safe for pregnant women. |
|
|
Term
| Drug used for chronic anti coagulation |
|
Definition
Warfarin
MOA: inhibits epoxide reductase. Decreases the Vitamin K dependent clotting factors (II,VII,IX,X,C,S). Monitor via PT levels
May produce a transient hypercoagulable state (acts on protein C/S first). Coadminister with Heparin
Teratogenic, crosses placenta to cause hydrops |
|
|
Term
| Drug used for its thrombolytic activity |
|
Definition
tPA (alteplase)
streptokinase
urokinase
MOA: converts plasinogen to plasmin
Used for ischemic strokes, Myocardial infarction therapies. |
|
|
Term
| Treatment for Heparin Toxicity |
|
Definition
Protamine sulfate
positively charge molecules bind to negatively charged Heparin molecules. |
|
|
Term
| Treatment for Warfarin toxicity |
|
Definition
Vitamin K (to restore clotting factors)
Fresh Frozen Plasma (to immediately address hemorrhage) |
|
|
Term
| Treatment for thrombolytic toxicity |
|
Definition
Aminocaproic acid
Inhibitor of fibrinolysis |
|
|
Term
| Drug used for Heparin Induced Thrombocytopenia |
|
Definition
Lepuridin
Bivalirudin
Directly decreases thrombin |
|
|
Term
| Drug treatment for Sickle Cell patients |
|
Definition
| Hydroxyurea (in addition with fluid therapy) |
|
|
