Term
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Definition
| A neurotransmitter used within the symapathetic branch of the autonomic nervous system. It is responsible for almost all of the induction of sympathetic responses. |
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Term
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Definition
A neurotransmitter used mainly within the Parasympathetic nervous system, but also utlized as
1. Major NT of all ganglia
2. NT on all postganglionic ParaSNS junctions
3. Somatic motor end plates
All skeletal muscle Action Potentials are perpetuated by the actions of this NT. |
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Term
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Definition
Inhibitor of the Na-based transport channel that brings Choline into the nerve terminal.
Ach cannot be formed without the action of choline and Acetyl-CoA in conjunction with Choline-Acetyl Transferase (ChAT). |
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Term
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Definition
Inhibitor of the movement of Ach into a vessicle via an antiporter.
SNS counterpart: Reserpine |
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Term
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Definition
Inhibits the exocytosis of the Ach-loaded vessicle at the nerve synapse.
Degrades the SNAP receptor on the internal surface of the cell membrane at the terminal. |
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Term
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Definition
Blocks the exocytosis of NE-loaded vessicles at the synapse of postganglionic cells in the sympathetic nervous system.
Counterpart in the ParaSNS: Botulinium toxin. |
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Term
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Definition
Blocks the movement of Dopamine into the vessicle where it can be converted into NE to be used as part of the SNS response.
Counterpart in the ParaSNS: Vesamicol |
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Term
| Tricyclic Antidepressants/Cocaine |
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Definition
Prevents the reuptake of NE back into the presynaptic nerve terminal (Reuptake-1)
Reuptake-1 is:
1. Sodium facilitated
2. NE goes back into the vessicles or is degraded cytoplasmically by Monoamine Oxidase (MAO) |
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Term
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Definition
Increases the release of Ach constantly until all Ach supplies are depleted; final outcome is a permanent decrease in Ach.
Consequences: Massive muscle contractions (Ach hyperrelease) followed by total paralysis (no Ach left) |
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Term
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Definition
| Muscarinic blocker affecting the actions of the ParaSNS. |
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Term
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Definition
Competitive inhibitor of the attachment of Ach at the nicotinic receptor in the ganglion of all ANS nerve pathways.
Blocks all ganglionic activity (ie most of the ANS responses)
* Ganglionic blocker (Nn antagonist) |
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Term
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Definition
Competitive inhibitor of Ach attachment at the nicotinic receptor at the neuromuscular junction.
* Neuromuscular blocker (Nm antagonist) |
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Term
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Definition
| Inhibits the action of MAO. Increases levels of all catecholamines (Epi, NE, Dopa) due to the decreased degradation of these Neurotransmitters. |
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Term
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Definition
COMT inhibitor.
Catechol-O-methyltransferase (COMT) is a vital portion of the Reuptake-2 system which takes catecholamines into the postsynaptic cell and degrades them.
Very little exists in adrenergic neurons. |
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